Use of Plant-Based Therapies and Menopausal Symptoms

Franco, Oscar H.; Chowdhury, Rajiv; Troup, Jenna; Voortman, Trudy; Kunutsor, Setor K; Kavousi, Maryam; Oliver‐Williams, Clare; Muka, Taulant

doi:10.1001/jama.2016.8012

Cited by 215 publications

(140 citation statements)

References 90 publications

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“…How are VMS typically treated? Almost everything imaginable has been tried, from sleeping on a metal-threaded cloth to all manner of herbs 38,39 and diets 40 (especially since low blood sugar, perhaps through a brain stress pathway 41 , is associated with VMS). Drugs include anti-anxiety medications to antidepressants 42 and other neuroactive interventions such as gabapentin, acupuncture 43 , clinical hypnosis 44 and stellate ganglion blockade 45 .…”

Section: Introductionmentioning

confidence: 99%

Progesterone for treatment of symptomatic menopausal women

Prior

2018

Climacteric

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This review's purpose is to highlight evidence that oral micronized progesterone (progesterone) is effective for hot flushes and night sweats (vasomotor symptoms, VMS), improves sleep and is likely safe in menopausal women (who are more than 1 year since last menstruation). Methods include randomized controlled clinical trials (RCT) supplemented with basic science, population and observational data as needed. The barrier to use of progesterone is lack of awareness that safety concerns with estrogenincluding 'menopausal hormone therapy' (MHT) are not applicable to progesterone. In a single 3-month RCT, progesterone (300 mg at bedtime) was effective treatment of VMS in 133 healthy menopausal women. It caused an overall 55% VMS decrease, no withdrawal-related VMS rebound and a greater VMS decrease in 46 women with !50 moderate-intense VMS/week. Progesterone is equally or more effective than estradiol in improving cardiovascular endothelial function and caused no cardiovascular safety concerns in a 3-month RCT. An 8-year prospective cohort study (E3N) in more than 80 000 menopausal women showed progesterone prevented breast cancer in estrogen-treated women. Multiple RCTs confirm that progesterone (300 mg daily at bedtime) does not cause depression and improves deep sleep. In conclusion, progesterone effectively treats VMS, improves sleep and may be the only therapy that symptomatic women, who are menopausal at a normal age and without osteoporosis, need. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Progesterone for treatment of symptomatic menopausal women

Prior

2018

Climacteric

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“…46 However, a 2016 systematic review and a meta-analysis concluded that there is currently insufficient evidence to support the use of black cohosh for vasomotor symptoms. 45 Another systematic review of black cohosh for vasomotor symptoms reached a similar conclusion. 47 More recently, a parallel, double blind, randomised controlled trial of 63 women showed that a combination of probiotic and red clover isoflavone was superior to placebo and reduced the frequency of vasomotor symptoms by 4.3 hot flushes per day on average compared with <1 per day with placebo (P<0.01, 95% CI −6.8 to −2.3).…”

Section: Diet and Supplementsmentioning

confidence: 75%

Non-hormonal treatments for menopausal symptoms

Hickey

Szabo

Hunter

2017

BMJ

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“…Herbal remedies, such as black cohosh and red clover might provide some relief but efficacy is variable between trials. 8 It is estimated that a novel treatment for menopausal flushes could currently benefit 10 million women in the UK alone, 9 and therefore a better understanding of the aetiology of such flushes and an associated targeted therapeutic is required. A hot flush is characterised by an intense feeling of heat, which often rises through the body, and intermittent activation of heat dissipation effectors, including peripheral cutaneous vasodilatation, sweating, and behavioural change, to reduce temperature.…”

Section: Introductionmentioning

confidence: 99%