A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder

Hannonen, Pekka; Malminiemi, Kimmo; Yli-Kerttula, U; Isomeri, Risto; Roponen, Pekka

doi:10.1093/rheumatology/37.12.1279

Cited by 121 publications

(78 citation statements)

References 6 publications

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“…A possible explanation for the decreased efficacy of the serotonin reuptake inhibitors (SSRI) compared to tricyclic antidpressants such as amitryptilline could reflect the absence of noradrenergic activity of SSRI's (41). In concordance with findings that tricyclic antidepressants as typified by amtriptyline, act to non-selectively inhibit the reuptake of serotonin (5-HT) and noradrenaline (NA) that was found to be helpfull in alleviating the pain symptoms of our and other study samples (8,19).…”

Section: Discussionsupporting

confidence: 86%

“…Recent clinical reports have suggested that analgesic effects of tricyclic antidepressants (TCAs) such as amitryptylline appear to be mediated partly via active metabolites, which act to selectively increase NA reuptake (10). Consequently, this has focused attention upon drugs which act to selectively increase 5-HT and NA levels for the treatment of chronic pain (18,19).…”

Section: Discussionmentioning

confidence: 99%

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A Comparison of Reboxetine and Amitryptilline in the Treatment of Fibromyalgia Syndrome with Co-morbid Depressive Symptoms: An Open-label Preliminary Study

Konuk

Ortancil

Bostanci

et al. 2010

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

A Comparison of Reboxetine and Amitryptilline in the Treatment of Fibromyalgia Syndrome with Co-morbid Depressive Symptoms: An Open-label Preliminary Study

Konuk

Ortancil

Bostanci

et al. 2010

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…69 Fibromyalgia is another condition in which efficacy of TCAs is reasonably well-established. 55,[70][71][72][73][74][75][76][77][78][79][80][81][82][83][84] Most studies have reported that TCAs were effective at doses lower than those needed for the treatment of depression. 80,83 The analgesic effect size (ES) (difference between 2 means [antidepressant analgesic effectplacebo analgesic effect] divided by the pooled estimate standard deviation) of TCAs ranged from 0.23 to 1.34 in fibromyalgia.…”

Section: (Continued)mentioning

confidence: 99%

Efficacy of Antidepressants as Analgesics: A Review

Dharmshaktu¹,

Tayal²,

Kalra³

2012

The Journal of Clinical Pharma

269

189

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Persistent pain disorders are usually not adequately alleviated by nonsteroidal anti‐inflammatory drugs or other simple analgesics. Use of antidepressants as adjuvant therapy for the control of persistent pain is currently being practiced in disorders such as fibromyalgia, neuropathic pain, rheumatoid conditions, low back pain, and headache. This review describes the various mechanisms of analgesic activity of antidepressants along with their efficacy and tolerability profiles. Meta‐analyses and clinical studies of these agents were retrieved through the use of MEDLINE, Google scholar, and Cochrane databases. Antidepressants are effective in both neuropathic and non‐neuropathic pain and have diverse mechanisms independent of their antidepressant effects. Tricyclic antidepressants (amitryptiline, nortryptiline, desipramine) are effective compounds in the treatment of neuropathic pain, fibromyalgia, low back pain, and headaches. Studies are ongoing for the dual serotonin norepinephrine reuptake inhibitors (duloxetine, venlafaxine) in several persistent pain conditions and these may be recommended in neuropathic pain, migraines, and fibromyalgia. Evidence suggests that although the analgesic effects of selective serotonin reuptake inhibitors (fluoxetine, paroxetine, citalopram) are limited and inconsistent, yet they have a superior tolerability profile compared with tricyclic antidepressants.

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“…43,50,51 In the clinical assay by Munguía-Izquierdo and LegazArrese, 52 physical exercise in warm water, three times a week for 16 weeks, was effective in reducing the pain and intensity of fi bromyalgia. Additionally, adult women who had not 24 Ginsberg et al, 30 Goldenberg et al, 31 Hannonen et al 32 Fluoxetine hydrochloride (20-80 mg/day) Selective inhibition of the 5-HT** uptake and of the Na+-K+-dependent transporter, adenosine triphosphatase…”

Section: Physical Exercisesmentioning

confidence: 99%

Uso da terapia não farmacológica, medicina alternativa e complementar na fibromialgia

Braz¹,

Paula

Diniz³

et al. 2011

Rev. Bras. Reumatol.

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Fibromyalgia is a chronic painful syndrome that affects up to 5% of the world population. It is associated with sleep and mood disorders, fatigue, and functional disability. Its pathogenesis involves a disorder of the central modulation of pain, impairment of the descending inhibitory system, and hyperactivity of substance P. Because of the extensive symptomatology of patients with fi bromyalgia and its multifactorial pathogenesis, its ideal treatment requires a multidisciplinary approach including the association of pharmacological and non-pharmacological therapies. The pharmacological therapy currently recommended for the syndrome includes antidepressants, calcium-channel modulators, muscle relaxants, and analgesics. In most cases, the non-pharmacological treatment consists of patient education, supervised aerobic physical activity, and cognitive-behavioral therapy. However, many patients do not respond satisfactorily, or have side effects associated with the long-term use of drugs, in addition to reporting diffi culties in adhering to a therapy based on exercises and physical medicine. Thus, physicians and patients are increasingly interested in an alternative and complementary therapy for fi bromyalgia. This review approaches the different therapeutic modalities used in fi bromyalgia, emphasizing the evidence of non-pharmacological therapy and use of alternative and complementary medicine for these patients.

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A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder

Cited by 121 publications

References 6 publications

A Comparison of Reboxetine and Amitryptilline in the Treatment of Fibromyalgia Syndrome with Co-morbid Depressive Symptoms: An Open-label Preliminary Study

A Comparison of Reboxetine and Amitryptilline in the Treatment of Fibromyalgia Syndrome with Co-morbid Depressive Symptoms: An Open-label Preliminary Study

Efficacy of Antidepressants as Analgesics: A Review

Uso da terapia não farmacológica, medicina alternativa e complementar na fibromialgia

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