A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps

Barna, Olha; Lohoida, Pavlo; Holovchenko, Yurii; Bazylevych, Andrii; Velychko, V. I.; Hovbakh, Iryna; Bula, Larysa; Shechter, Michael

doi:10.1186/s12937-021-00747-9

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Two randomized control studies out of Ukraine and Thailand have shown that increasing magnesium uptake can help relieve pregnancy-induced leg and muscle cramps 6 . It is an effective, safe treatment for nocturnal leg cramps 7 . However, smaller studies suggest that magnesium oxide is not significantly better than a placebo for the older population.…”

Section: Discussionmentioning

confidence: 99%

Homeopathic High Magnesium Muscle Cramp Treatment Causing Renal Dysfunction

Ogbuehi,

Guo,

Atalay

et al. 2023

J. Drug Delivery Ther.

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Herbal medications are often perceived as safe since they are believed to be sourced from natural sources and are sought after for various health conditions, including muscle cramps. While some herbal medicines may provide relief, it is crucial to exercise caution and be aware of their potential side effects, including the risk of exacerbating renal failure when they contain high magnesium levels. This is a case of a 76-year-old woman who experienced renal failure after consuming herbal medication rich in magnesium to alleviate muscle cramps. Keywords: Acute renal failure, hyper magnesium, muscle cramps

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Section: Discussionmentioning

confidence: 99%

Homeopathic High Magnesium Muscle Cramp Treatment Causing Renal Dysfunction

Ogbuehi,

Guo,

Atalay

et al. 2023

J. Drug Delivery Ther.

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“…Quinine has been shown to be effective in treating NLCs but is not recommended by the US Food and Drug Administration due to severe side effects (6). Magnesium supplements are often used as a preventative treatment for NLCs (7,8); however, their effectiveness is controversial (2,9,10). Magnesium supplements are widely marketed for the prophylaxis of NLCs since a double-blind, placebo-controlled study proved their effectiveness in pregnant women (11).…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin K2 in the treatment of nocturnal leg cramps in the older population: Study protocol of a randomized, double-blind, controlled trial

Liu

Zhu²,

Wang³

et al. 2023

Front. Nutr.

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IntroductionNocturnal leg cramps (NLCs) are sudden contractions of the leg muscles, usually in the posterior calf muscles at night, affecting sleep quality. Because the precise pathophysiology of NCLs is unclear, different interventions have been proposed. There is conflicting evidence regarding the efficacy of conventional interventions in preventing cramps. Thus, the present study aims to investigate the effects of vitamin K2 for NLCs in a prospective randomized, double-blind, controlled trial.Methods and analysisThis multicenter, randomized, double-blind, placebo-controlled clinical study will enroll older age (≥65-year-old) with two or more documented episodes of NLCs during 2 weeks of screening. Participants will be randomized to receive vitamin K2 or a similar-looking placebo for 8 weeks in a 1:1 ratio. Follow-up visits will be scheduled each week at the beginning of 4-week intervention, then participants will be visited semimonthly. The primary outcome is the difference in the mean number of NLCs per week in the vitamin K2 and placebo arms. The secondary outcomes include the severity and duration of NLCs in the vitamin K2 and placebo arms. Two hundred patients will be needed, for this two-treatment parallel design study, to achieve a probability is 90% that the study will detect a treatment difference at a two-sided 0.04 significance level, if the difference between treatments is 3.6 (difference in means between treatment arms) NLC events.DiscussionNocturnal Leg Cramps (NLCs) are a common musculoskeletal disorder in the general population, but effective and safe interventions have not been established. Our previous study has shown vitamin K2 was effective to reduce the frequency, severity, and duration of dialysis-related muscle cramps with a good safety profile. This randomized controlled trial (RCT) of rigorous methodological design will help to establish the effectiveness of vitamin K2 for the management of NLCs in older population. The findings of this RCT will encourage the studies of vitamin K2 in musculoskeletal disorders.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier, NCT05547750.

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Arabinogalactan Prevented APAP-Induced Acute Liver Injury by Regulating the Intestinal Flora in Mice

Jiang

Zhang²,

Zhou

et al. 2023

Lecture Notes in Computer Science

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Background: This study aimed to explore the mechanism by which arabinogalactan (AG) inhibited Nacetyl-para-aminophenol (APAP)-induced acute liver injury in mice. The balance of the mouse intestinal ora and the relationship between AG treatment and the PI3K/AKT and NF-κB signaling pathways were evaluated to con rm a liver-gut interaction. Methods: Mice were administered 2 different doses of AG (150 or 300 mg/kg body weight) by gavage for 7 days and liver injury was induced by a single injection of APAP (250 m/kg). Hematoxylin-eosin staining, terminal deoxynucleotidyl transferase dUTP nick-end labeling, and Hoechst 33258 uorescence staining of liver tissue were used to analyze liver damage. Western blots were used to evaluate expression of proteins related to PI3K/AKT and NF-κB signaling pathways, and changes in the hierarchical structure of the intestinal ora were determined. Results: AG pretreatment increased the proportion of Lactobacillus and decreased the abundance of species from norank_o_Clostridiaceae and Prevotella in mouse feces compared with APAP-only treated mice. AG pretreatment reversed glutathione depletion and CYP2E1 overexpression, reduced the production of malondialdehyde and 4-hydroxynonenal, and decreased the levels of alanine aminotransferase, aspartate aminotransferase, tumor necrosis factor-α and interleukin-1β compared with the APAP-only treated mice.The levels of proteins related to the PI3K/AKT signaling pathway were similar between the AG and control groups. AG pretreatment signi cantly reduced APAP-induced hepatocyte apoptosis and necrosis and in ammatory in ltration into the liver. Conclusion: PI3K/AKT pathway-mediated BAX expression and the NF-κB signaling cascade were inhibited by AG. AG protected the intestinal ora composition, which subsequently suppressed oxidative stress in the liver, improved the in ammatory response, and reduced hepatocyte apoptosis and necrosis.

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A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps

Cited by 3 publications

References 34 publications

Homeopathic High Magnesium Muscle Cramp Treatment Causing Renal Dysfunction

Homeopathic High Magnesium Muscle Cramp Treatment Causing Renal Dysfunction

Effect of vitamin K2 in the treatment of nocturnal leg cramps in the older population: Study protocol of a randomized, double-blind, controlled trial

Arabinogalactan Prevented APAP-Induced Acute Liver Injury by Regulating the Intestinal Flora in Mice

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