A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients

Shahmansouri, Nazila; Farokhnia, Mehdi; Abbasi, Seyed-Hesammeddin; Kassaian, Seyed Ebrahim; Tafti, Ahmad-Ali Noorbala; Gougol, Amirhossein; Yekehtaz, Habibeh; Forghani, Saeedeh; Mahmoodian, Mehran; Saroukhani, Sepideh; Arjmandi-Beglar, Akram; Akhondzadeh, Shahin

doi:10.1016/j.jad.2013.11.003

Cited by 107 publications

(74 citation statements)

References 54 publications

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“…Many studies about the antidepressant effects of saffron has been done on human, that the following can be noted: Shahmansouri et al in their study showed that short-term treatment with saffron capsules (30 mg daily for six weeks) and fluoxetin (40 mg daily for six weeks) had the same antidepressants effects in patients [22]. In another study, the effect of saffron (10 mg essence of saffron) was measured as an anti-depression factor and the results were compared with impiramine (30 -100 mg).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial

Basirimoghadam

Hamzei

Moslem

et al. 2016

Zahedan J Res Med Sci

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Background: Anxiety is an unpleasant state of feeling agitation and pressure induced by the patient's fear of hospitalization, anesthesia or surgery. Objectives: The present study is aimed to compare the effects of dried extract of saffron and diazepam on soothing the preherniorrhaphy surgery anxiety. Patients and Methods:In this double blind clinical study, during 8 months, 102 patients were studied in 2012. all the patients in intervention group (n = 50) received 25 mg dried extract of saffron and participants in control group (n = 52) received 5 mg oral diazepam. Level of anxiety of the patients was measured using speillberger state-trait anxiety inventory (STAI) before intervention and 3 hours after administration (immediately after entering the surgery room) filled out by the patients. The patients in the two groups were compared concerning level of anxiety before/after intervention. The two groups of participants had almost equal demographic features.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial

Basirimoghadam

Hamzei

Moslem

et al. 2016

Zahedan J Res Med Sci

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“…Saffron (Crocus sativus L.) is a traditional therapeutic agent (11) mental, and cardiovascular disorders; moreover, it is used as an analgesic and antiinflammatory agent (12). Recent experimental and clinical findings indicate that saffron may have potentials in the treatment of mild to moderate depression, as well as some sexual problems (13)(14)(15)(16). The main carotenoid in saffron, crocin, seems to be responsible for its beneficial effects on mental and sexual health (14,17).…”

Section: Introductionmentioning

confidence: 99%

Effects of Saffron Aqueous Extract and Its Main Constituent, Crocin, on Health-Related Quality of Life, Depression, and Sexual Desire in Coronary Artery Disease Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Abedimanesh

Ostadrahimi

Bathaie

et al. 2017

Iran Red Crescent Med J

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Background: Depression and sexual problems are common in patients with coronary artery disease (CAD) and can influence their quality of life. Objectives: The aim of this study was to compare the efficacy of saffron and its main constituent, crocin, in improving mental and sexual health and ultimately quality of life in CAD patients. Methods: This double-blind, placebo-controlled, randomized clinical trial was carried out during 8 weeks in 3 groups, including 1 placebo and 2 intervention groups. The study sample included 58 CAD patients within the age range of 40 -65 years, referred to Shahid Madani cardiovascular hospital, Tabriz, Iran, from April 2015 to November 2016. The intervention groups received saffron aqueous extract (SAE; 30 mg; n, 20) or crocin (30 mg; n,19). All the groups completed the demographic questionnaire, Beck depression inventory-II (BDI-II), Hulbert index of sexual desire (HISD), and MacNew health-related quality of life questionnaire.

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“…In recent meta-analyses and systematic reviews, it was concluded that curcumin (Al-Karawi et al, 2015) and saffron (Hausenblas et al, 2013; were more effective than placebo for the treatment of major depressive disorder. In several studies, saffron's antidepressant effects were also found to be similar to the antidepressant medications fluoxetine (Akhondzadeh Basti et al, 2007;Noorbala et al, 2005;Shahmansouri et al, 2014) and imipramine (Akhondzadeh et al, 2004). However, further research is warranted, particularly in determining optimal treatment dosages and length of treatment.…”

Section: Introductionmentioning

confidence: 96%

Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study

Lopresti

Drummond

2017

Journal of Affective Disorders

120

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Several studies have supported the antidepressant effects of curcumin (from the spice turmeric) and saffron for people with major depressive disorder. However, these studies have been hampered by poor designs, small sample sizes, short treatment duration, and similar intervention dosages. Furthermore, the antidepressant effects of combined curcumin and saffron administration are unknown.

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A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients

Cited by 107 publications

References 54 publications

Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial

Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial

Effects of Saffron Aqueous Extract and Its Main Constituent, Crocin, on Health-Related Quality of Life, Depression, and Sexual Desire in Coronary Artery Disease Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study

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