A randomized controlled trial to determining the effect of cinnamon on the plasma levels of soluble forms of vascular adhesion molecules in type 2 diabetes mellitus

Mirmiran, Parvin; Davari, Mina; Hashemi, Reza; Hedayati, Mehdi; Sahranavard, Shamim; Bahreini, Shohreh; Tavakoly, Rahele; Talaei, Behrouz

doi:10.1038/s41430-019-0523-9

Cited by 12 publications

(12 citation statements)

References 25 publications

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“…119 Furthermore, there was no significant difference in the serum levels of ICAM-1 and VCAM-1 in patients between the groups. 120 In addition, many in vitro experiments have identified the anti-inflammatory effects of cinnamon. The production of adhesion molecules and subsequent attachment of leukocytes to ECs are the key early events in the pathological process of atherogenesis.…”

Section: Reviewmentioning

confidence: 99%

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

et al. 2021

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Section: Reviewmentioning

confidence: 99%

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

et al. 2021

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“…Diabetes mellitus (DM) is a non-communicable prevalent disease leading to a high mortality and morbidity rate annually [1,2]. 387 million people suffer from DM globally and this figure is expected to rise to 366 million patients by 2035 [3].…”

Section: Introductionmentioning

confidence: 99%

Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial

Davari

Hashemi

Mirmiran

et al. 2020

Nutr J

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116

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Background and objectives: NF-kB, SIRT1 and systemic inflammation factors including hs-CRP, IL-6 and TNF-α accelerate atherosclerosis pathogenesis. Our purpose was to evaluate the effect of daily supplementation of threegram cinnamon on plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α among type 2 diabetes patients. Subjects and methods: A randomized, double blind, and controlled clinical trial was performed with 44 adult patients who were 25 to 70 years old with type 2 diabetes, randomized to two intervention (n = 22) and control (n = 22) groups differing by daily three grams cinnamon supplementation and placebo for 8 weeks, respectively. The plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α were measured by ELISA assay at the beginning and end of the study. Results: After 8-week intervention, 39 subjects (n = 20 in the cinnamon and n = 19 in the placebo groups) ended up the trial. It was not observed significant difference in levels of hs-CRP (P = 0.29), TNF-α (P = 0.27), IL-6 (P = 0.52), and Sirtuin-1 (P = 0.51) in between group comparison. While, the result showed significant difference in levels of NF-kB (P = 0.02) between groups. As well as, in among group comparison, there was not observed significant differences except in hs-CRP (P = 0.008) in placebo group. Conclusions: This study elucidated that cinnamon supplementation has no beneficial effects in reduction of NF-kB, SIRT1, hs-CRP, IL-6 and TNF-α levels in type 2 diabetes patients which have a considerable role in development of atherogenesis.

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“…A meta-analysis that included 23 studies (1,070 subjects) concluded that there was no association between cinnamon consumption and differences in LDL-cholesterol, high-density lipoprotein cholesterol, and HbA1c levels. Studies on cinnamon in vitro, in animals, and in humans are listed in Table 5 [9,45,[131][132][133][134][135][136][137][138][139][140][141][142][143][144]. Again, allowance for different exposome features, such as microbiota composition, may be pertinent here [145].…”

Section: Cinnamon and Cardiovascular Diseasementioning

confidence: 99%

Cinnamon: an aromatic condiment applicable to chronic kidney disease

Moreira

Brum

Reis

et al. 2023

Kidney Res Clin Pract

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Cinnamon, a member of the Lauraceae family, has been widely used as a spice and traditional herbal medicine for centuries and hasshown beneficial effects in cardiovascular disease, obesity, and diabetes. However, its effectiveness as a therapeutic intervention forchronic kidney disease (CKD) remains unproven. The bioactive compounds within cinnamon, such as cinnamaldehyde, cinnamicacid, and cinnamate, can mitigate oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia, which are commoncomplications in patients with CKD. In this narrative review, we assess the mechanisms by which cinnamon may alleviate complicationsobserved in CKD and the possible role of this spice as an additional nutritional strategy for this patient group.

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A randomized controlled trial to determining the effect of cinnamon on the plasma levels of soluble forms of vascular adhesion molecules in type 2 diabetes mellitus

Cited by 12 publications

References 25 publications

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial

Cinnamon: an aromatic condiment applicable to chronic kidney disease

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