A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort

Benito-Ruiz, Pere; Camacho-Zambrano, M.M.; Carrillo-Arcentales, J.N.; Mestanza-Peralta, M.A.; Vallejo-Flores, C.A.; López, Samuel Vargas; Villacís-Tamayo, R.A.; Zurita-Gavilanes, L.A.

doi:10.1080/09637480802498820

Cited by 78 publications

(103 citation statements)

References 30 publications

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“…In several clinical trials, the efficacy of oral collagen peptide supplementation could be demonstrated in osteoarthritic patients (McAlindon et al 2011;Benito-Ruiz et al 2009;Adam 1991;Krug 1979;Oberschelp 1985;Bruyère et al 2012). After treatment, significantly reduced pain and increased mobility were reported.…”

Section: Discussionmentioning

confidence: 99%

“…The calculated effect size (d = 0.300) of a BCP treatment compared with placebo was similar to the results of the Clark study, although in the current investigation the daily dosage was reduced from 10 to 5 g, and the duration of the treatment was shortened from 24 to 12 weeks. The dose reduction to 5 g was based on the observation that in clinical trials in OA patients (Adam 1991;Benito-Ruiz et al 2009;Bruyère et al 2012;Carpenter et al 2005;Krug 1979;McAlindon et al 2011;Moskowitz 2000;Oberschelp 1985), and the efficacy of the collagen peptide intake seems to be independent from BMI of the subjects. This indicates that a daily intake of 10 g might not be required in subjects with OA.…”

Section: Discussionmentioning

confidence: 99%

“…In a placebo-controlled trial, McAlindon et al (2011) demonstrated increased content of proteoglycan as part of the ECM of cartilage tissue in patients with mild osteoarthritis after 10 g of collagen peptide intake. In addition, clinical studies with patients suffering from degenerative joint diseases showed an improvement in pain symptoms (Bello and Oesser 2006;Benito-Ruiz et al 2009;Bruyère et al 2012;Moskowitz 2000). It has to be assumed that functional joint discomforts are characterized by a subclinical short-term degradation of cartilage due to the increased stress on the knee joint.…”

Section: Introductionmentioning

confidence: 99%

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Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides

Zdzieblik

Oesser

Gollhofer

et al. 2017

Appl. Physiol. Nutr. Metab.

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this article has been changed to the CC BY 4.0 license. The PDF and HTML versions of the article have been modified accordingly. Abstract:The aim of the study was to evaluate the use of specific collagen peptides in reducing pain in athletes with functional knee problems during sport. Athletic subjects (n = 139) with functional knee pain ingested 5 g of bioactive collagen peptides (BCP) or a placebo per day for 12 weeks. The primary outcome of the study was a change in pain intensity during activity, which was evaluated by the participants and the attending physicians using a visual analogue scale (VAS). As secondary endpoints, pain intensity under resting conditions, the range of motion of the knee joint, and the use of additional therapeutic options were assessed. The results revealed a statistically significant improvement in activity-related pain intensity in the verum group compared with placebo. (⌬VAS BCP = 19.5 ± 2.4; ⌬VAS Placebo = 13.9 ± 2.1; p = 0.046). The results were confirmed by the physician's assessment. (⌬VAS BCP = 16.7 ± 1.8; ⌬VAS Placebo = 12.2 ± 1.8; p = 0.021). Pain under resting conditions was also improved, but no significance compared with placebo was detected (⌬VAS BCP = 10.2 ± 18.4; ⌬VAS Placebo = 7.4 ± 15.2; p = 0.209). Due to the high joint mobility at baseline, no significant changes of this parameter could be detected. The use of additional treatment options was significantly reduced after BCP intake. The study demonstrated that the supplementation of specific collagen peptides in young adults with functional knee problems led to a statistically significant improvement of activity-related joint pain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides

Zdzieblik

Oesser

Gollhofer

et al. 2017

Appl. Physiol. Nutr. Metab.

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“…2). Схожа динаміка показників за WOMAC і індексом Лекена була отримана в інших дослідженнях, у яких строк терапії ГК становив від 3 до 6 місяців [3,14,15]. Більше того, у роботі T. Trč (2010) при порівнян-ні ГК і глюкозаміну сульфату після 3 місяців терапії перший виявився більш ефективним щодо зменшен-ня відчуття болю, що фіксували за ВАШ [25].…”

Section: ðåçóëüòàòè òà ¿õ îáãîâîðåííÿunclassified

Ефективність І Безпечність Лікування Хворих На остеоартроз Колінних Суглобів Гідролізатом Колагену (FORTIGEL®)

Кondratiuk

Ter-Vartan'ian

2022

TRAUMA

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Мета дослідження — оцінити ефективність і безпеку використання проФЛЕКС (Schonen, Швейцарія) — гідролізату колагену (FORTIGEL®) у хворих з остеоартозом колінних суглобів. У відкрите клінічне дослідження включили 30 хворих (8 чоловіків і 22 жінки) віком 45–74 роки (середній вік 59 ± 8 років) з остеоартрозом колінних суглобів, тривалість патології становила в середньому 8,9 ± 6,0 року. Усім хворим на додаток до нестероїдного протизапального препарату було призначено гідролізат колагену (FORTIGEL®) перорально у дозі 10 г на добу. Тривалість лікування — 3 місяці.За період спостереження відмічено позитивну динаміку, що підтверджувалася зменшенням суб’єктивного відчуття болю за візуальною аналоговою шкалою наприкінці дослідження на 44 % (р < 0,05) у стані спокою і на 62 % (р < 0,05) при рухах порівняно з контрольною групою. Зниження індексу Лекена було більш виражене — на 48 % (р < 0,05). Більшість пацієнтів відзначали позитивний вплив гідролізату колагену (FORTIGEL®): 10 % — значне покращення, 53 % — помірне поліпшення і 37 % — без змін. В основній групі відзначено більш виражене зниження дози диклофенаку натрію порівняно з контрольною групою в кінці спостереження — на 73 і 47 % відповідно. Суттєвих побічних ефектів, що потребували б відміни питного гідролізату колагену (FORTIGEL®), протягом дослідження не реєструвалося.проФЛЕКС (гідролізат колагену (FORTIGEL®)) є ефективним та безпечним засобом для комплексного лікування хворих на остеоартроз колінних суглобів.

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“…A dietary collagen supplement has also been suggested to improve joint pain and mobility [5,6]. Warland et al reported that the concentration of plasma amino acids varied after oral administration of fermented milk containing collagen hydrolysate [24].…”

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confidence: 99%

Correlation of Plasma Amino Acid Concentrations and Chondroprotective Effects of Glucosamine and Fish Collagen Peptide on the Development of Osteoarthritis

Ohnishi

Osaki

Matahira³

et al. 2013

The Journal of Veterinary Medical Science

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AbSTRAcT. We investigated the correlation of plasma amino acid concentrations and the effects of glucosamine and fish collagen peptide (FcP) on osteoarthritis (OA). OA was induced according to the rabbit anterior cruciate ligament transection (AcLT) model. After surgery, the rabbits were orally administered FcP (F group), glucosamine (G group) or both (FG group) for 4 weeks. The control group (c group) was not administered anything. blood was collected before surgery (pre-AcLT) and before euthanasia (post-AcLT). changes in the alanine, threonine and methionine concentrations were significant between pre-and post-ACLT. The correlation between the histological assessment and arginine concentration post-ACLT was significant. These findings indicate that measurement of plasma amino acids is useful for evaluation of the efficacy of intervention for OA.

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A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort

Abstract: CH is safe and effective and warrants further consideration as a food ingredient.

Cited by 78 publications

References 30 publications

Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides

Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides

Ефективність І Безпечність Лікування Хворих На остеоартроз Колінних Суглобів Гідролізатом Колагену (FORTIGEL®)

Correlation of Plasma Amino Acid Concentrations and Chondroprotective Effects of Glucosamine and Fish Collagen Peptide on the Development of Osteoarthritis

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