A Randomized Controlled Trial of Subcutaneous Nerve Stimulation for Back Pain Due to Failed Back Surgery Syndrome: The SubQStim Study

Eldabe, Sam; Taylor, Rod S; Goossens, Stefaan; Bouche, Bénédicte; Gültuna, Ismail; Green, Colin; Tinsley, Jennifer; Luyet, Pierre‐Philippe; Buchser, Eric

doi:10.1111/ner.12784

Cited by 33 publications

(30 citation statements)

References 27 publications

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“…In patients with failed back surgery syndrome, this study found positive effects on pain measured with a VAS score and an improvement in the patients' global impression of change score. However, this study had unclear risk of bias in three of five categories in the risk of bias tool .…”

Section: Discussionmentioning

confidence: 84%

“…In one trial that measured pain relief with sphenopalatine ganglion stimulation for chronic cluster headaches, significantly more patients achieved pain relief through full stimulation compared to subperception or sham stimulation ( p < 0.0001) . In patients with failed back surgery syndrome, one study compared subcutaneous nerve stimulation to optimized medical management . This trial reported a significant reduction in pain for patients receiving the intervention plus optimized medical management (33.9% of patients achieved a pain reduction of 50% or greater, measured with a VAS) compared with a control group of patients receiving optimized medical management alone (1.9%) .…”

Section: Resultsmentioning

confidence: 99%

“…In patients with failed back surgery syndrome, one study compared subcutaneous nerve stimulation to optimized medical management . This trial reported a significant reduction in pain for patients receiving the intervention plus optimized medical management (33.9% of patients achieved a pain reduction of 50% or greater, measured with a VAS) compared with a control group of patients receiving optimized medical management alone (1.9%) .…”

Section: Resultsmentioning

confidence: 99%

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Effectiveness of Neurostimulation Technologies for the Management of Chronic Pain: A Systematic Review

Hofmeister

Memedovich

Brown

et al. 2020

Neuromodulation: Technology at the Neural Interface

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Section: Discussionmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of Neurostimulation Technologies for the Management of Chronic Pain: A Systematic Review

Hofmeister

Memedovich

Brown

et al. 2020

Neuromodulation: Technology at the Neural Interface

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“…The prevalence and cost of LBP, which has been turned into a general problem, shows an increasing trend in societies (11). LBP epidemiology has been studied in adults more widely, but there are few studies on this problem in children (12).…”

Section: Contextmentioning

confidence: 99%

Investigating the Prevalence of Musculoskeletal Pain Among Iranian Children and Adolescents: A Systematic Review and Meta-Analysis

et al. 2019

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Context: Musculoskeletal pain is very common among students and adolescents. Objectives: The present systematic review and meta-analysis study aimed to determine the prevalence of musculoskeletal pain among Iranian children and adolescents. Data Sources, Study Selection, and Data Extraction: All articles on the prevalence of musculoskeletal disorders in Iranian adolescents were searched in the Google Scholar, four Iranian databases and five international English-language databases using the keywords of "pain", "musculoskeletal disorders", "low back pain", "adolescents", "students", and a combination of these keywords. The obtained data were analyzed by Comprehensive Meta-Analysis (CMA) software. Results: The findings showed that out of 9 studies found in this systematic review and metaanalysis, 6 articles were about low back pain, 6 articles about neck pain, and 3 articles about shoulder pain, respectively. According to the findings, 25.4% (95% CI: 19.0 to 33.0) of the children experienced pain; the prevalence rates of low back pain, knee pain, and the shoulder pain were 26.2% (95% CI: 14.3 to 43.0), 22% (95% CI: 14.5 to 32.0), and 29.3% (95% CI: 20.1 to 40.7) in Iranian adolescents, respectively. Conclusion: Considering the high prevalence of pain among Iranian adolescents, it is necessary to carry out appropriate interventions for pain prevention among this age group.

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“…Good outcomes have been reported applying PNFS in the management of CLBP in patients with or without a medical history of lumbosacral spinal surgery and refractory to common therapies 14‐17 . Recent evidence from randomized controlled trials (RCTs) indicates that the use of PNFS may significantly improve pain outcomes when used as a primary technique or as an add‐on therapy to SCS 18,19 …”

Section: Introductionmentioning

confidence: 99%

Peripheral Nerve Field Stimulation for Chronic Back Pain: Therapy Outcome Predictive Factors

Eldabe

Slavin

Rigoard³

et al. 2020

Pain Practice

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Objective To identify variables that influence pain reduction following peripheral nerve field stimulation (PNFS) in order to identify a potential responder profile. Methods Exploratory univariate and multivariate (random forest) analyses were performed separately on 2 randomized controlled trials and a registry; all included patients with chronic back pain, mainly failed back surgery syndrome. An international expert panel judged the clinical relevance of variables to identify responders by consensus. Results Variables identified that may help predict PNFS success in patients with back pain include patient and pain characteristics (age, time since onset of pain and spinal surgery, pain medication history, position and size of pain area, pain severity, mixed nociceptive/neuropathic pain, health‐related quality of life, depression, functional disability, and leg pain status), implant procedure variables (the number and position of leads, paresthesia coverage, and amount of pain relief during the trial), and programming (number of programs, cathodes, and anodes; pulse rate; pulse width; and percentage of device usage). Conclusions While these analyses are exploratory and restricted to a limited sample size, they suggest variables that may play a role in predicting a therapeutic response. These results, however, are informative only and should be cautiously interpreted. Future research to validate the variables in a clinical study is needed.

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A Randomized Controlled Trial of Subcutaneous Nerve Stimulation for Back Pain Due to Failed Back Surgery Syndrome: The SubQStim Study

Abstract: The results indicate that the addition of SQS to OMM is more effective than OMM alone in relieving low back pain at up to nine months.

Cited by 33 publications

References 27 publications

Effectiveness of Neurostimulation Technologies for the Management of Chronic Pain: A Systematic Review

Effectiveness of Neurostimulation Technologies for the Management of Chronic Pain: A Systematic Review

Investigating the Prevalence of Musculoskeletal Pain Among Iranian Children and Adolescents: A Systematic Review and Meta-Analysis

Peripheral Nerve Field Stimulation for Chronic Back Pain: Therapy Outcome Predictive Factors

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