Effectiveness of Neurostimulation Technologies for the Management of Chronic Pain: A Systematic Review

Hofmeister, Mark; Memedovich, Ally; Brown, Sage; Saini, Manik; Dowsett, Laura E.; Lorenzetti, Diane; McCarron, Tamara L.; MacKean, Gail; Clement, Fiona

doi:10.1111/ner.13020

Cited by 51 publications

(44 citation statements)

References 47 publications

(78 reference statements)

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“…Neuromodulation has shown promise in various neuropathic pain states 136 . A number of case reports indicate that neuromodulation may help refractory CIPN 137,138 , but RCT data are lacking.…”

Section: Non-pharmacologicalmentioning

confidence: 99%

Recent advances in understanding chemotherapy-induced peripheral neuropathy

Gordon-Williams

Farquhar-Smith

2020

F1000Res

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Chemotherapy-induced peripheral neuropathy (CIPN) is a common cause of pain and poor quality of life for those undergoing treatment for cancer and those surviving cancer. Many advances have been made in the pre-clinical science; despite this, these findings have not been translated into novel preventative measures and treatments for CIPN. This review aims to give an update on the pre-clinical science, preventative measures, assessment and treatment of CIPN.

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Section: Non-pharmacologicalmentioning

confidence: 99%

Recent advances in understanding chemotherapy-induced peripheral neuropathy

Gordon-Williams

Farquhar-Smith

2020

F1000Res

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“…Most chronic neuropathic pain conditions have been reported to respond to spinal cord stimulation, including failed back surgery syndrome, complex regional pain syndrome and chronic peripheral neuropathies. 2,4,8 Additional expanding indications include refractory angina, diabetic neuralgia, post-herpetic neuralgia, and visceral or peripheral ischemic pain. 2,4 Contraindications include active infections, immunosuppression and inability to withhold anticoagulation.…”

Section: Who Is Eligible?mentioning

confidence: 99%

“…1,3 When conventional therapies produce unacceptable adverse effects or do not provide sufficient pain relief, spinal cord stimulation (neuromodulation) may offer a rescue option, either alone or in conjunction with other modalities. 3,4 Neuromodulation, defined as the alteration of nerve activity through targeted stimulus delivery, was first introduced in 1967. 2,3,5 It is based on the principle of electrically stimulating the dorsal column of the spinal cord, to mask pain signals.…”

mentioning

confidence: 99%

Spinal cord stimulation: a nonopioid alternative for chronic pain management

Hong

Varshney

Hare

et al. 2020

CMAJ

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“…The electrical stimulation of peripheral nerves has become a growing trend during the last decade to treat many drugresistant painful conditions (recent reviews in [1][2][3]). Chronic refractory headaches are favored targets for neuromodulation, in particular neurovascular or autonomicrelated cephalalgias, such as chronic migraine, cluster headache or hemicrania continua [4][5][6][7][8], and painful neuropathies originating in a trigeminal branch or occipital nerve [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

et al. 2020

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Background: Stimulation of the occipital or trigeminal nerves has been successfully used to treat chronic refractory neurovascular headaches such as migraine or cluster headache, and painful neuropathies. Convergence of trigeminal and occipital sensory afferents in the 'trigeminocervical complex' (TCC) from cutaneous, muscular, dural, and visceral sources is a key mechanism for the input-induced central sensitization that may underlie the altered nociception. Both excitatory (glutamatergic) and inhibitory (GABAergic and glycinergic) mechanisms are involved in modulating nociception in the spinal and medullary dorsal horn neurons, but the mechanisms by which nerve stimulation effects occur are unclear. This study was aimed at investigating the acute effects of electrical stimulation of the greater occipital nerve (GON) on the responses of neurons in the TCC to the mechanical stimulation of the vibrissal pad. Methods: Adult male Wistar rats were used. Neuronal recordings were obtained in laminae II-IV in the TCC in control, sham and infraorbital chronic constriction injury (CCI-IoN) animals. The GON was isolated and electrically stimulated. Responses to the stimulation of vibrissae by brief air pulses were analyzed before and after GON stimulation. In order to understand the role of the neurotransmitters involved, specific receptor blockers of NMDA (AP-5), GABA A (bicuculline, Bic) and Glycine (strychnine, Str) were applied locally. Results: GON stimulation produced a facilitation of the response to light facial mechanical stimuli in controls, and an inhibition in CCI-IoN cases. AP-5 reduced responses to GON and vibrissal stimulation and blocked the facilitation of GON on vibrissal responses found in controls. The application of Bic or Str significantly reduced the facilitatory effect of GON stimulation on the response to vibrissal stimulation in controls. However, the opposite effect was found when GABAergic or Glycinergic transmission was prevented in CCI-IoN cases.

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Effectiveness of Neurostimulation Technologies for the Management of Chronic Pain: A Systematic Review

Cited by 51 publications

References 47 publications

Recent advances in understanding chemotherapy-induced peripheral neuropathy

Recent advances in understanding chemotherapy-induced peripheral neuropathy

Spinal cord stimulation: a nonopioid alternative for chronic pain management

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

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