2016
DOI: 10.1016/j.jaip.2016.03.012
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A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics

Abstract: Background Broccoli sprouts (BS) are the richest source of sulforaphane (SFN), which is a potent inducer of Phase II enzymes, which play a critical role in preventing oxidative stress (OS) and inflammation. Objectives To determine if ingestion of whole BS improves airway inflammatory and physiologic outcomes, and OS in adults with asthma and allergic sensitization to an indoor allergen. Methods The study is a double-blind, placebo-controlled, randomized trial to compare the effects of BS to placebo (alfalf… Show more

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Cited by 46 publications
(38 citation statements)
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“…This is intriguing because of an assumed link between mitochondrial dysfunction and ROS production and the necessity of squelching mitochondria-derived free radicals through the activation of Nrf2. This additional functional impact of SFN is of potential importance given the more than 30 clinical trials currently underway testing SFN for the treatment of a variety of diseases including prostate cancer, obstructive pulmonary disease, and sickle cell disease [7], [10], [47].…”
Section: Discussionmentioning
confidence: 99%
“…This is intriguing because of an assumed link between mitochondrial dysfunction and ROS production and the necessity of squelching mitochondria-derived free radicals through the activation of Nrf2. This additional functional impact of SFN is of potential importance given the more than 30 clinical trials currently underway testing SFN for the treatment of a variety of diseases including prostate cancer, obstructive pulmonary disease, and sickle cell disease [7], [10], [47].…”
Section: Discussionmentioning
confidence: 99%
“…The short-time studies included also the three studies on respiratory problems. In the work of Sudini et al [41], the first observation was the extremely short time of intervention of three days, the shortest of all the analyzed studies. The intervention was carried out using food, not pills or supplements, because the interest was to study if the intake of cruciferous foods with high content in glucosinolate, especially glucoraphanin (sulforaphane), could have the same effect that was found in the interventions with broccoli sprout extract (BSE).…”
Section: Short-time Studiesmentioning
confidence: 99%
“…Within the short-term studies (Table S1), we found two documents on prostate [39] and melanoma [40], three papers on respiratory pathologies [41][42][43], and one on type 2 diabetes [44]. The main limitation observed in these studies is the length or duration of the study, of 1 month or less, because the validity of the data in terms of changes in bioavailability of the intake of compounds could be acceptable, but for the evaluation of data from tissues, the time of exposition is too low.…”
Section: Short-time Studiesmentioning
confidence: 99%
“…For example, a large randomized trial of vitamin E supplements led to a 10% reduction in the risk of chronic lung disease (asthma, emphysema, chronic bronchitis, bronchiectasis) in women [58]. Some small clinical trials report that dietary antioxidants or vitamin supplements improve asthma control or lung function in children or adults with asthma [59,60], whereas a trial of broccoli sprouts, which is a rich source of sulforaphane was ineffective in improving biomarkers of airway inflammation or clinical outcomes in adults with atopic asthma [61]. Several clinical trials of dietary supplements are underway for the treatment of chronic respiratory diseases, including one investigating the effects resveratrol in modulating metabolism and cardiovascular risk profile in patients with COPD [41].…”
Section: Naturally Occurring Dietary Antioxidant Supplementsmentioning
confidence: 99%