Targeting oxidant-dependent mechanisms for the treatment of respiratory diseases and their comorbidities

Thomson, Neil C.

doi:10.1016/j.coph.2017.11.013

Cited by 25 publications

(19 citation statements)

References 61 publications

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“…Oxidantantioxidant imbalance plays a crucial role in the development of COPD. Oxidative stress caused by smoking and environmental pollution can lead to extensive tissue damage and COPD exacerbation in patients at about 63 years of age [16,17]. Some markers, such as MDA in sputum, appear to be useful for monitoring exacerbation-associated oxidative stress in COPD [18].…”

Section: Oxidation-antioxidant Imbalance Is Involved In the Developmementioning

confidence: 99%

Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease

et al. 2020

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Chronic Obstructive Pulmonary Disease (COPD) is a worldwide health problem associated with high morbidity and mortality, especially in elderly patients. Aging functions include mitochondrial dysfunction, cell-to-cell information exchange, protein homeostasis and extracellular matrix dysregulation, which are closely related to chronic inflammatory response and oxidation-antioxidant imbalance in the pathogenesis of COPD. COPD displays distinct inflammaging features, including increased cellular senescence and oxidative stress, stem cell exhaustion, alterations in the extracellular matrix, reduced levels of endogenous anti-inflammaging molecules, and reduced autophagy. Given that COPD and inflammaging share similar general features, it is very important to identify the specific mechanisms of inflammaging, which involve oxidative stress, inflammation and lung mesenchymal stem cell function in the development of COPD, especially in elderly COPD patients. In this review, we highlight the studies relevant to COPD progression, and focus on mechanisms associated with inflammaging.

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Section: Oxidation-antioxidant Imbalance Is Involved In the Developmementioning

confidence: 99%

Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease

et al. 2020

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“…Early studies have found that the chronic sustained expression of extracellular SOD (EC-SOD) protects lungs from radiotherapy-induced injury. Therefore, AEOL-10150 is used to treat lung injury after radiotherapy [24]. The results showed that the respiratory rate of Fisher-344 rats increased 8 weeks after radiotherapy (28 Gy), reaching a peak at 18 weeks.…”

Section: Introductionmentioning

confidence: 99%

Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant

Zhang¹,

Zhou²,

Zhang³

2018

Military Med Res

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AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase (SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard (SM), nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome (ARS). AEOL-10150 performed well in animal safety studies, and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated, indicating that AEOL-10150 has potential as a new catalytic antioxidant drug. In this article, we review improvements in AEOL-10150 in preclinical pharmacodynamic studies, especially regarding anti-SM, chlorine gas and radiation exposure studies.

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“…It is also important to understand the pathology of muscle wasting at a cellular level, since the inherent adaptability of muscle tissue offers nutritional therapeutic options to reverse or delay disease progression (Passey et al, 2016). Oxidative stress is implicated in the pathogenesis of respiratory diseases, including COPD (Thomson, 2018), and is characterised by the release of free radicals, resulting in cellular degeneration that damages cell membranes (Ohira et al, 2008). In patients with COPD, oxidative stress is thought to exacerbate the loss of lean muscle mass, so promotes cachexia (Rawal and Yadav, 2015).…”

mentioning

confidence: 99%

‘Mind the gap’: the importance of managing malnutrition in chronic obstructive pulmonary disease

Shepherd¹,

Bowell

2019

Br J Nurs

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Malnutrition is linked to poor outcomes in patients with chronic obstructive pulmonary disease (COPD), and reduced fat free mass and low BMI are independent risk factors for increased mortality. However, weight loss is not inevitable and can be prevented or reversed so screening for malnutrition is essential. The latest guidelines for managing malnutrition in COPD recommend first-line nutritional support. In particular, patients with a BMI <20 kg/m2 should be prescribed oral nutritional supplements (ONS), which have been shown to significantly improve outcomes. However, this guidance is often not implemented locally, increasing the likelihood of malnutrition, hospital admission and increased healthcare costs. Ready-prepared, low-volume, high-protein, high-energy drinks can improve compliance with ONS, particularly in people who are unable to tolerate high volumes. ONS therefore play an important role in managing malnutrition in COPD, helping to reduce its physiological and economic effects.

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Targeting oxidant-dependent mechanisms for the treatment of respiratory diseases and their comorbidities

Cited by 25 publications

References 61 publications

Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease

Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease

Improvements in SOD mimic AEOL-10150, a potent broad-spectrum antioxidant

‘Mind the gap’: the importance of managing malnutrition in chronic obstructive pulmonary disease

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