A randomized controlled trial of preprocedure administration of parecoxib for therapeutic endoscopic retrograde cholangiopancreatography

Abstract

IntroductionParecoxib is occasionally used for analgesia in postprocedural patients. The clinical efficacy of parecoxib used for endoscopic retrograde cholangiopancreatography (ERCP) is controversial. The aim of the study was to determine the clinical efficacy of preprocedure administration of parecoxib for therapeutic ERCP patients.MethodsEighty-five patients who underwent therapeutic ERCP in a single year were randomly assigned to normal saline group (C, n = 43) and parecoxib group (P, n = 42). Patients in group C received normal saline and those in group P received 40 mg of parecoxib intravenously in equivalent volume. Patients in both groups received the saline or parecoxib 60 seconds before administration of the sedative agents. All patients were monitored for the depth of sedation by using the NarcotrendTM monitor, maintaining stage D0–E0 during ERCP. All patients were oxygenated with 100% O2 via nasal cannula and sedated with 0.03 mg/kg of intravenous midazolam and 1 μg/kg of intravenous fentanyl as well as the titration of intravenous propofol. After the ERCP procedure, pethidine in an intramuscular dose of 0.5–1.0 mg/kg was used as rescue medication. The pain scores (visual analog scale [VAS], 0–10) at 2, 12, and 24 hours post-ERCP, the total number of doses of pethidine used, the dose volume of pethidine used, patient satisfaction, endoscopist satisfaction, and complications were recorded.ResultsThere were no significant differences in sedative and analgesic agents used during the procedure, pain at 24 hours post-ERCP, endoscopist satisfaction, and complications in both groups. The total number of doses of pethidine used post-ERCP in group C was significantly higher than in group P. Additionally, the mean pain score at 2 and 12 hours post-ERCP in group C was significantly greater than in group P. Patient satisfaction in group P was higher than in group C.ConclusionPreprocedure administration of parecoxib for therapeutic ERCP patients was clinically effective. The analgesic efficacy of a standard dose of parecoxib was clearly demonstrated during the first 12 hours postprocedure. Additionally, patient satisfaction in the parecoxib group was also higher than in the control group.

Sedation-related complications in gastrointestinal endoscopy

“…Fortunately, a lower incidence of procedural nausea/vomiting and pain after the GIE procedure is observed even in a therapeutic endoscopy [9] . Opioid and cyclo-oxygenase-2-inhibitors can be safely and effectively used for procedural pain in GIE patients [10] . Sedated patients are discharged from the recovery area when the discharge criteria are met.…”

Anaesthetic considerations for endoscopic retrograde cholangio-pancreatography procedures

“…Preprocedure administration of parecoxib has been shown to reduce patient pain scores at 2 and 12 h after ERCP procedures ( [31,32] abstracts). Options for pain relief include administration of opioids (such as fentanyl), paracetamol or anti-inflammatory agents.…”

Anesthetic Management for Laparoscopic Cholecystectomy

“…Several medications used intraoperatively for prevention and treatment of postoperative pain are the uses of local anesthesia, opioids, nonsteroidal anti-inflammatory drugs, and multimodal analgesia techniques. Additionally, preprocedure administration of parecoxib is clinically effective [33].…”