A randomized controlled trial of smoking cessation methods in patients newly-diagnosed with pulmonary tuberculosis

Aryanpur, Mahshid; Hosseini, Mostafa; Masjedi, Milad; Mortaz, Esmaeil; Tabarsi, Payam; Soori, Hamid; Emami, Habib; Heidari, Gholamreza; Dizagie, Mehdi Kazempour; Baikpour, Masoud

doi:10.1186/s12879-016-1727-4

Cited by 27 publications

(35 citation statements)

References 22 publications

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“…The studies included a total of 13 141 participants from 11 countries. Seven studies (29%) were carried out in China [27,29,35,36,38,44,45], three (13%) each in India [39,42,46], Brazil [30,32,40] and Iran [22,26,33], two (8%) each in Malaysia [28,31] and South Africa [24,37] and one (4%) each in Pakistan [41], Syria [43], Thailand [23] and Turkey [34]. Four studies recruited participants from the community, one from a prison, and the remaining 19 recruited participants from medical clinics.…”

Section: Resultsmentioning

confidence: 99%

“…Interventions evaluated included: counseling plus bupropion versus usual care [26,41], counseling plus bupropion versus counseling only [41], counseling plus bupropion versus brief advice [26] and graded duration of counseling combined with different doses of NRT [40]. Interventions evaluated included: counseling plus bupropion versus usual care [26,41], counseling plus bupropion versus counseling only [41], counseling plus bupropion versus brief advice [26] and graded duration of counseling combined with different doses of NRT [40].…”

Section: Pharmacotherapy Plus Counselingmentioning

confidence: 99%

“…The outcome was assessed at 6 months with biological verification in two of the studies [26,41], while for the third study, the outcome was assessed at 1 year by self-reported 7-day point prevalence abstinence [40]. Counseling plus bupropion was more effective than brief advice [26], but was not superior to counseling alone [41]. Counseling plus bupropion was more effective than brief advice [26], but was not superior to counseling alone [41].…”

Section: Pharmacotherapy Plus Counselingmentioning

confidence: 99%

“…Three studies did not use a placebo control when evaluating pharmacological interventions [25,33,41]. Ten studies (42%) failed to indicate whether their outcome assessors were blinded to study condition [25,29,[32][33][34]36,[39][40][41]45], four studies (17%) reported that their assessors were not blinded to study condition [27,30,37,42] and the remaining 10 studies (42%) reported using blinded assessors [23,24,26,28,31,35,38,43,44,46]. Ten studies (42%) failed to indicate whether their outcome assessors were blinded to study condition [25,29,[32][33][34]36,[39][40][41]45], four studies (17%) reported that their assessors were not blinded to study condition [27,30,37,42] and the remaining 10 studies (42%) reported using blinded assessors [23,24,26,28,…”

Section: Performance and Detection Biasmentioning

confidence: 99%

“…Interventions evaluated included: counseling plus bupropion versus usual care [26,41], counseling plus bupropion versus counseling only [41], counseling plus bupropion versus brief advice [26] and graded duration of counseling combined with different doses of NRT [40]. The outcome was assessed at 6 months with biological verification in two of the studies [26,41], while for the third study, the outcome was assessed at 1 year by self-reported 7-day point prevalence abstinence [40]. We pooled results of the two studies that compared bupropion plus counseling to usual care, and the result favored the combination over usual care (Table S2).…”

Section: Pharmacotherapy Plus Counselingmentioning

confidence: 99%

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The efficacy of smoking cessation interventions in low‐ and middle‐income countries: a systematic review and meta‐analysis

et al. 2019

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Aims To summarize evidence for the efficacy of smoking cessation interventions in low‐ and middle‐income countries (LMICs). Design Systematic review and meta‐analysis of randomized controlled trials. Setting LMICs as defined by the World Bank. Participants Adult current cigarette smokers residing in LMICs. Interventions Behavioral and/or pharmacotherapy smoking cessation interventions. Measurements PubMed MEDLINE, EMBASE (embase.com), Cochrane Central Register of Controlled Trials (Wiley), PsycINFO (Ebsco), SciELO, WHO Global Index Medicus and Scopus were searched from inception to 4 April 2018. Only studies with at least 6 months of follow‐up were included. We used the most rigorous assessment of abstinence reported by each study. Effect sizes were computed from abstracted data. Where possible, a meta‐analysis was performed using Mantel–Haenzel random‐effect models reporting odds ratios (OR) and 95% confidence intervals (CI). Findings Twenty‐four randomized controlled trials were included. Six investigated the efficacy of pharmacological agents. Four trials that compared nicotine replacement therapy (NRT) to placebo found NRT improved cessation rates (n : NRT 546, control 684, OR = 1.76, 95% CI = 1.30–2.77, P < 0.001, I2 = 13%). Eight trials found that behavioral counseling was more effective than minimal interventions (e.g. brief advice); n : Counseling 2941, control 2794, OR = 6.87, 95% CI = 4.18–11.29, P < 0.001, I2 = 67%). There was also evidence of the benefit of brief advice over usual care (n : Brief advice 373, control 355, OR = 2.46, 95% CI = 1.56–3.88, P < 0.001, I2 = 0%). Conclusion Nicotine replacement therapy, behavioral counseling and brief advice appear to be effective in aiding smoking cessation in low‐ and middle‐income countries. There is limited rigorous research on other smoking cessation interventions in these regions.

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Section: Resultsmentioning

confidence: 99%

Section: Pharmacotherapy Plus Counselingmentioning

confidence: 99%

Section: Pharmacotherapy Plus Counselingmentioning

confidence: 99%

Section: Performance and Detection Biasmentioning

confidence: 99%

“…Interventions evaluated included: counseling plus bupropion versus usual care [26,41], counseling plus bupropion versus counseling only [41], counseling plus bupropion versus brief advice [26] and graded duration of counseling combined with different doses of NRT [40]. The outcome was assessed at 6 months with biological verification in two of the studies [26,41], while for the third study, the outcome was assessed at 1 year by self-reported 7-day point prevalence abstinence [40]. We pooled results of the two studies that compared bupropion plus counseling to usual care, and the result favored the combination over usual care (Table S2).…”

Section: Pharmacotherapy Plus Counselingmentioning

confidence: 99%

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The efficacy of smoking cessation interventions in low‐ and middle‐income countries: a systematic review and meta‐analysis

et al. 2019

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Antidepressants for smoking cessation

Howes

Hartmann‐Boyce

Livingstone‐Banks

et al. 2020

Cochrane Database of Systematic Reviews

343

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Antidepressants for smoking cessation

Hajizadeh

Howes

Theodoulou

et al. 2023

Cochrane Database of Systematic Reviews

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Background The pharmacological profiles and mechanisms of antidepressants are varied. However, there are common reasons why they might help people to stop smoking tobacco: nicotine withdrawal can produce short‐term low mood that antidepressants may relieve; and some antidepressants may have a specific effect on neural pathways or receptors that underlie nicotine addiction. Objectives To assess the evidence for the efficacy, harms, and tolerability of medications with antidepressant properties in assisting long‐term tobacco smoking cessation in people who smoke cigarettes. Search methods We searched the Cochrane Tobacco Addiction Group Specialised Register, most recently on 29 April 2022. Selection criteria We included randomised controlled trials (RCTs) in people who smoked, comparing antidepressant medications with placebo or no pharmacological treatment, an alternative pharmacotherapy, or the same medication used differently. We excluded trials with fewer than six months of follow‐up from efficacy analyses. We included trials with any follow‐up length for our analyses of harms. Data collection and analysis We extracted data and assessed risk of bias using standard Cochrane methods. Our primary outcome measure was smoking cessation after at least six months' follow‐up. We used the most rigorous definition of abstinence available in each trial, and biochemically validated rates if available. Our secondary outcomes were harms and tolerance outcomes, including adverse events (AEs), serious adverse events (SAEs), psychiatric AEs, seizures, overdoses, suicide attempts, death by suicide, all‐cause mortality, and trial dropouts due to treatment. We carried out meta‐analyses where appropriate. Main results We included a total of 124 studies (48,832 participants) in this review, with 10 new studies added to this update version. Most studies recruited adults from the community or from smoking cessation clinics; four studies focused on adolescents (with participants between 12 and 21 years old). We judged 34 studies to be at high risk of bias; however, restricting analyses only to studies at low or unclear risk of bias did not change clinical interpretation of the results. There was high‐certainty evidence that bupropion increased smoking cessation rates when compared to placebo or no pharmacological treatment (RR 1.60, 95% CI 1.49 to 1.72; I 2 = 16%; 50 studies, 18,577 participants). There was moderate‐certainty evidence that a combination of bupropion and varenicline may have resulted in superior quit rates to varenicline alone (RR 1.21, 95% CI 0.95 to 1.55; I 2 = 15%; 3 studies, 1057 participants). However, there was insufficient evidence to establish whether a combination of bupropion and nicotine replacement therapy (NRT) resulted in superior quit rates to NRT a...

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A randomized controlled trial of smoking cessation methods in patients newly-diagnosed with pulmonary tuberculosis

Cited by 27 publications

References 22 publications

The efficacy of smoking cessation interventions in low‐ and middle‐income countries: a systematic review and meta‐analysis

The efficacy of smoking cessation interventions in low‐ and middle‐income countries: a systematic review and meta‐analysis

Antidepressants for smoking cessation

Antidepressants for smoking cessation

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