A randomized controlled trial of the effects of non‐surgical periodontal therapy on cardiac function assessed by echocardiography in type 2 diabetic patients

Wang, Yi; Liu, Hin Nam; Zhen, Zhe; Pelekos, George; Wu, Meiling; Chen, Yan; Tonetti, Maurizio S.; Tse, Hung Fat; Yiu, Kai Hang; Jin, Lijian

doi:10.1111/jcpe.13291

Cited by 20 publications

(33 citation statements)

References 53 publications

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“… 172 Under active periodontal treatment intervention, these systemic inflammation biomarkers can be significantly down-regulated. 173 Therefore, the disordered oral flora of patients with periodontitis can not only mediate the periodontal inflammatory state but also affect the systemic inflammatory state of the distal body.…”

Section: Oral Microbes and Diabetesmentioning

confidence: 99%

Oral microbiota in human systematic diseases

et al. 2022

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Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with the host to reflect the information and status of immunity and metabolism through two-way communication along the oral cavity and the systemic organs. The oral cavity is one of the most important interaction windows between the human body and the environment. The microenvironment at different sites in the oral cavity has different microbial compositions and is regulated by complex signaling, hosts, and external environmental factors. These processes may affect or reflect human health because certain health states seem to be related to the composition of oral bacteria, and the destruction of the microbial community is related to systemic diseases. In this review, we discussed emerging and exciting evidence of complex and important connections between the oral microbes and multiple human systemic diseases, and the possible contribution of the oral microorganisms to systemic diseases. This review aims to enhance the interest to oral microbes on the whole human body, and also improve clinician’s understanding of the role of oral microbes in systemic diseases. Microbial research in dentistry potentially enhances our knowledge of the pathogenic mechanisms of oral diseases, and at the same time, continuous advances in this frontier field may lead to a tangible impact on human health.

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Section: Oral Microbes and Diabetesmentioning

confidence: 99%

Oral microbiota in human systematic diseases

et al. 2022

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“…Accumulating evidence from observational, intervention, and experimental studies has associated PD with a number of comorbidities, such as atherosclerosis, diabetes mellites, respiratory disease, cancer, etc [ 6 , 7 ]. Moreover, our recent studies suggest that PD is a risk factor for myocardial dysfunction [ 8 , 9 ]. The periodontal systemic associations could be briefly explained by the spillover of subgingival pathogens into the bloodstream, as well as a cascade of systemic inflammation and autoimmune damage from the host response [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study

et al. 2021

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Background Emerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a two-sample Mendelian randomization (MR) study, and investigated for the first time the possible causal impact of PD on host susceptibility to COVID-19 and its severity. Methods Summary statistics of COVID-19 susceptibility and severity were retrieved from the COVID-19 Host Genetics Initiative and used as outcomes. Single nucleotide polymorphisms associated with PD in Genome-wide association study were included as exposure. Inverse-variance weighted (IVW) method was employed as the main approach to analyze the causal relationships between PD and COVID-19. Three additional methods were adopted, allowing the existence of horizontal pleiotropy, including MR-Egger regression, weighted median and weighted mode methods. Comprehensive sensitivity analyses were also conducted for estimating the robustness of the identified associations. Results The MR estimates showed that PD was significantly associated with significantly higher susceptibility to COVID-19 using IVW (OR = 1.024, P = 0.017, 95% CI 1.004–1.045) and weighted median method (OR = 1.029, P = 0.024, 95% CI 1.003–1.055). Furthermore, it revealed that PD was significantly linked to COVID-19 severity based on the comparison of hospitalization versus population controls (IVW, OR = 1.025, P = 0.039, 95% CI 1.001–1.049; weighted median, OR = 1.030, P = 0.027, 95% CI 1.003–1.058). No such association was observed in the cohort of highly severe cases confirmed versus those not hospitalized due to COVID-19. Conclusions We provide evidence on the possible causality of PD accounting for the susceptibility and severity of COVID-19, highlighting the importance of oral/periodontal healthcare for general wellbeing during the pandemic and beyond.

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“…An overall modest association of periodontitis with ACVD has been consistently reported across different study cohorts 3,4 . Furthermore, periodontal treatment leads to a favorable effect on endothelial and cardiac function 5,6 . These findings indicate that the periodontal‐cardiovascular linkage is not likely attributed to confounders.…”

Section: Introductionmentioning

confidence: 74%

Porphyromonas gingivalis lipopolysaccharide affects the angiogenic function of endothelial progenitor cells via Akt/FoxO1 signaling

Deng

Gong

Chen

et al. 2022

J of Periodontal Research

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Aims Endothelial progenitor cells (EPCs) function as the angiogenic switch of many physiological and pathological conditions. We aimed to investigate the effects of Porphyromonas gingivalis lipopolysaccharide on the angiogenic capacity of EPCs and delineate the underlying mechanisms. Materials and Methods EPCs were isolated from human umbilical blood. CCK‐8 assay was undertaken to analyze the cell viability. The migration and tube formation capacity were assessed by wound healing and tube formation, respectively. The protein expression of Akt/p‐Akt, endothelial nitric oxide synthase (eNOS)/p‐eNOS, and Forkhead box O1 (FoxO1)/p‐FoxO1 was determined by Western blot. The intracellular localization of FoxO1 was evaluated by immunofluorescent staining. Results P. gingivalis LPS at 10 μg/ml significantly increased the viability (10.9 ± 2.9%), migration (16.3 ± 3.1%), and tube formation (38.6 ± 5.5%) of EPCs, along with increased phosphorylation of Akt, eNOS, and FoxO1. Mechanistically, Akt inhibition by specific inhibitor wortmannin and FoxO1 forced expression by adenovirus transfection in EPCs markedly attenuated the P. gingivalis LPS‐induced eNOS activation, tube formation, and migration. Moreover, P. gingivalis LPS‐induced phosphorylation and nuclear exclusion of FoxO1 were blunted by Akt inhibition. Conclusions The present study suggests that P. gingivalis LPS could affect the angiogenic function of EPCs through the Akt/FoxO1 signaling. The current findings may shed light on the clinical association of periodontitis with aberrant angiogenesis seen in atherosclerotic plaque rupture.

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A randomized controlled trial of the effects of non‐surgical periodontal therapy on cardiac function assessed by echocardiography in type 2 diabetic patients

Cited by 20 publications

References 53 publications

Oral microbiota in human systematic diseases

Oral microbiota in human systematic diseases

Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study

Porphyromonas gingivalis lipopolysaccharide affects the angiogenic function of endothelial progenitor cells via Akt/FoxO1 signaling

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