A Randomized, Controlled Trial of Vitamin D Supplementation upon Musculoskeletal Health in Postmenarchal Females

Ward, Kate A; Das, Gautam; Roberts, Stephen A; Berry, J. L.; Adams, Judith E.; Rawer, Rainer; Mughal, M Zulf

doi:10.1210/jc.2009-2725

Cited by 141 publications

(111 citation statements)

References 35 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…There are several possible explanations for this observation including the lower serum 25(OH)D which is also known to have an adverse effect on muscle function. 1,14,15 However we detected no significant associations between the rise in 25(OH)D from winter to summer and the fall in injury incidence. Although this may have been due to the relatively low power of the current study, there are other possible explanations.…”

Section: Discussioncontrasting

confidence: 69%

“…10 Dancers also demonstrate high incidence of injury which has been partly explained by inadequate levels of physical fitness, 11 particularly by low levels of muscular strength. 12,13 Inadequate muscular strength has been associated with vitamin D deficiency in athletes 14,15 and non-athletes 16,17 alike. However, Wang and DeLuca 18 suggested that the effect of vitamin D on muscle function might be indirect as they could not detect a known vitamin D receptor in skeletal muscle.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D status in professional ballet dancers: Winter vs. summer

Wolman

Wyon

Koutedakis

et al. 2013

Journal of Science and Medicine in Sport

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Vitamin D status in professional ballet dancers: Winter vs. summer

Wolman

Wyon

Koutedakis

et al. 2013

Journal of Science and Medicine in Sport

View full text Add to dashboard Cite

“…(24) The most promising window of intervention seems to be in the premenarcheal period, both for calcium supplementation (18) and vitamin D, in the subset of girls who have low baseline vitamin D levels. (12) The randomized, controlled trial of vitamin D supplementation by Ward and colleagues (9) did not show a beneficial effect on mineral accretion, bone geometry or strength, muscle force, or power, in postmenarcheal females. The lack of an effect of calcium, vitamin D, or exercise after completion of puberty in the above studies, (9,12) strongly suggest that prepuberty and baseline levels are important predictors of bone mass accretion.…”

Section: Discussionmentioning

confidence: 96%

“…(12) The randomized, controlled trial of vitamin D supplementation by Ward and colleagues (9) did not show a beneficial effect on mineral accretion, bone geometry or strength, muscle force, or power, in postmenarcheal females. The lack of an effect of calcium, vitamin D, or exercise after completion of puberty in the above studies, (9,12) strongly suggest that prepuberty and baseline levels are important predictors of bone mass accretion. Finally, the lack of an effect of vitamin D in boys, be it during the main trial or in the extension, may have several explanations.…”

Section: Discussionmentioning

confidence: 96%

Persistent Effect of Vitamin D Supplementation on Musculoskeletal Parameters in Adolescents One Year After Trial Completion

Ghazal

Al-Shaar

Maalouf

et al. 2016

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

We showed a beneficial effect of vitamin D supplementation on musculoskeletal parameters in adolescent girls in a 1-year, randomized, double-blinded placebo-controlled trial (RCT). Our objective for this study was to investigate the residual effect of vitamin D supplementation on bone mineral content (BMC), bone mineral density (BMD), at the lumbar spine and hip, lean mass, and height, 1 year after trial completion. We performed post hoc analyses in 167 adolescents, 86 girls and 81 boys, age 13.9 AE 2 years, who received vitamin D or placebo during the trial, and continued into the follow-up trial. Musculoskeletal parameters were measured at baseline, 12 months (intervention), and 24 months (follow-up). ANOVA and t tests were used to compare results between the placebo group and the merged vitamin D arms (200 or 2000 IU/day), by gender. Baseline characteristics were comparable between treatment groups at entry into the extension. Girls who had received vitamin D during the trial, had significantly larger hip BMC increments compared to those assigned to placebo, at 24 months compared to study entry, but not 24 compared to 12 months, which persisted in adjusted analyses. There were no significant differences in bone mass changes between treatment groups in boys, at 24 months compared to 12 months or to baseline. The beneficial effect of vitamin D supplementation on hip bone mass, achieved in girls during the trial, persisted 1 year after trial completion. These net cumulative increments, 1 year after discontinuation of supplementation, may have important implications on optimizing peak bone mass accretion in adolescent girls.

show abstract

“…Through these mechanisms vitamin D may have a role in prevention of falls and subsequently fractures in older people, although evidence does not conclusively support this (84)(85)(86) . The possible implications of poor vitamin D status for long-term musculoskeletal health and rising incidence of vitamin D deficiency in teenagers in the UK prompted a study into the effects of vitamin D supplementation in adolescent South-Asian girls in Manchester (53,87) . Over 60% had serum 25-hydroxy-vitamin D (25(OH)D) levels less than 25 nmol/l (87) .…”

Section: Vitamin Dmentioning

confidence: 99%

Musculoskeletal phenotype through the life course: the role of nutrition

Ward

2011

Proc. Nutr. Soc.

View full text Add to dashboard Cite

This review considers the definition of a healthy bone phenotype through the life course and the modulating effects of muscle function and nutrition. In particular, it will emphasise that optimal bone strength (and how that is regulated) is more important than simple measures of bone mass. The forces imposed on bone by muscle loading are the primary determinants of musculoskeletal health. Any factor that changes muscle loading on the bone, or the response of bone to loading results in alterations of bone strength. Advances in technology have enhanced the understanding of a healthy bone phenotype in different skeletal compartments. Multiple components of muscle strength can also be quantified. The critical evaluation of emerging technologies for assessment of bone and muscle phenotype is vital. Populations with low and moderate/high daily Ca intakes and/or different vitamin D status illustrate the importance of nutrition in determining musculoskeletal phenotype. Changes in mass and architecture maintain strength despite low Ca intake or vitamin D status. There is a complex interaction between body fat and bone which, in addition to protein intake, is emerging as a key area of research. Muscle and bone should be considered as an integrative unit; the role of body fat requires definition. There remains a lack of longitudinal evidence to understand how nutrition and lifestyle define musculoskeletal health. In conclusion, a life-course approach is required to understand the definition of healthy skeletal phenotype in different populations and at different stages of life.

show abstract

A Randomized, Controlled Trial of Vitamin D Supplementation upon Musculoskeletal Health in Postmenarchal Females

Cited by 141 publications

References 35 publications

Vitamin D status in professional ballet dancers: Winter vs. summer

Vitamin D status in professional ballet dancers: Winter vs. summer

Persistent Effect of Vitamin D Supplementation on Musculoskeletal Parameters in Adolescents One Year After Trial Completion

Musculoskeletal phenotype through the life course: the role of nutrition

Contact Info

Product

Resources

About