A randomized controlled trial examining the effects of intranasal oxytocin on alcohol craving and intimate partner aggression among couples

Flanagan, Julianne C.; Nietert, Paul J.; Sippel, Lauren M.; Jarnecke, Amber M.; Kirby, Charli M.; Hogan, Jasara N.; Massa, Andrea A.; Brower, Jessica; Back, Sudie E.; Parrott, Dominic J.

doi:10.1016/j.jpsychires.2022.06.011

Cited by 7 publications

(2 citation statements)

References 103 publications

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“…However, in a study, it was stated that the dose of oxazepam needed for detoxification with intranasal oxytocin administration of 24 IU twice a day for 3 days did not decrease compared with the placebo group 36 . In another study, it was found that alcohol craving and aggression were not decreased with a single dose of 40 IU oxytocin 37 . In oxytocin studies conducted with patients with alcohol use disorder, it can be stated that the clinical response may change with factors such as the patient’s compliance to the treatment, duration of treatment, and dose.…”

Section: Oxytocin For Treating Alcohol and Substance Use Disordersmentioning

confidence: 94%

Oxytocin in the Treatment of Psychiatric Disorders

KAGIZMAN,

HOCAOGLU

2023

MMJ

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Oxytocin is a peptide hormone that is most known for its role in reproduction. However, many effects other than reproduction have been defined. The lifetime prevalence of mental disorders is approximately 20%, and they have a significant ratio among the diseases that lead to disability. Treatment resistance may cause the mental disorder to become chronic and increase disability. With the examination of the oxytocinergic system, both the elucidation of the etiology of the diseases and their evaluation as a new treatment option have come to the fore. In various studies, it has been desired to create a more effective treatment model by measuring the level of oxytocin in psychiatric disorders, examining its receptor, and applying exogenous oxytocin in the treatment. In this review, an overview of oxytocin’s efficacy in treatment is presented by considering the relationship between psychiatric disorders and the oxytocinergic system.

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Section: Oxytocin For Treating Alcohol and Substance Use Disordersmentioning

confidence: 94%

Oxytocin in the Treatment of Psychiatric Disorders

KAGIZMAN,

HOCAOGLU

2023

MMJ

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“…Data for the current study were drawn from the baseline assessment of that project, before administration of study medication. Full study procedures, sampling criteria, sample demographic and clinical characteristics, and primary outcomes from the trial have been published previously (Flanagan et al, 2022). Inclusion criteria required that participants were 18 years or older, and at least one partner in each couple (1) met DSM-5 (American Psychiatric Association, 2013) diagnostic criteria for current AUD (assessed by the Mini-International Neuropsychiatric Interview; Sheehan et al, 1998) and ( 2) endorsed at least one instance of physical IPV (e.g., hitting, slapping) during their relationship.…”

Section: Participantsmentioning

confidence: 99%

Examining the role of posttraumatic stress disorder symptoms in intimate partner violence among couples with alcohol use disorder

Flanagan,

Hogan,

Massa

et al. 2024

Aggressive Behavior

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Separate literatures indicate that both alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are robust risk factors for using intimate partner violence (IPV). Despite the strength of these relative literatures, and the common co‐occurrence of AUD and PTSD, their combined effects on IPV have rarely been examined. This study begins to address this gap by exploring the moderating effects of provisional PTSD diagnosis on the relation between heavy alcohol consumption and physical IPV using a multilevel modeling approach. Participants were adult romantic couples (N = 100) with current AUD and a history of physical IPV in their relationship. Results from the between‐couple comparison indicate that couples who reported more heavy drinking days also experienced more physical IPV when at least one partner had probable PTSD. However, the within‐couple comparison indicated that among partners without a provisional PTSD diagnosis, those with fewer heavy drinking days compared to their partner also reported more physical IPV perpetration. These preliminary and exploratory findings require replication and extension but provide new and important information regarding the complex intersection of heavy drinking, PTSD, and IPV among couples with AUD.

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