A randomized controlled trial comparing indwelling pleural catheters with talc pleurodesis (NVALT-14)

Boshuizen, Rogier C.; Noort, Vincent van der; Burgers, J. A.; Herder, Gerarda J.M.; Hashemi, S.; Hiltermann, T Jeroen N; Kunst, Peter W.A.; Stigt, Jos A.; Heuvel, Michel M. van den

doi:10.1016/j.lungcan.2017.01.019

Cited by 49 publications

(26 citation statements)

References 14 publications

(29 reference statements)

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“…IPC is becoming a worthy alternative for pleurodesis in symptomatic malignant pleurisy as shown by the TIME2 randomized controlled trial (RCT) comparing IPC with chest tube and talc pleurodesis. 8 Although the primary end point in a 2017 RCT with superiority design was not met, 12 the use of IPC showed to be effective and led to fewer reinterventions and hospital admissions. The efficacy of IPC in inducing pleurodesis could potentially be enhanced by coating these devices with sclerosing agents such as silver nitrate.…”

Section: Discussionmentioning

confidence: 99%

Success rate of medical thoracoscopy and talc pleurodesis in malignant pleurisy: A single‐centre experience

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Success rate of medical thoracoscopy and talc pleurodesis in malignant pleurisy: A single‐centre experience

et al. 2018

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“…Lastly, the use of IPC to deal with KS-associated chylous effusions has not been reported before. IPC have a proven efficacy and safety in the palliation of malignant pleural effusions, but previous clinical trials excluded patients with impaired immunity and/or chylothorax 28–30. The use of IPCs has not been shown to increase the risk of infection while patients receive chemotherapy 31.…”

Section: Discussionmentioning

confidence: 99%

Intractable pleural effusion in Kaposi sarcoma following antiretroviral therapy in a Caucasian female infected with HIV

et al. 2020

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We report the case of a 57-year-old Caucasian woman with AIDS-related disseminated Kaposi sarcoma (KS) characterised by the combination of several unusual features. The chylous nature of the pleural effusions, the documented parietal pleural involvement at thoracoscopy and the marked clinical worsening through an immune reconstitution syndrome following antiretroviral therapy initiation represent several rare situations that occurred in the same female patient. In addition, the use of indwelling pleural catheters for dyspnoea palliation also represents a rare therapeutic intervention. This case is a reminder of the possibility of AIDS-related pleural KS, now uncommon in the era of antiretroviral therapy.

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“…Состав: доксициклин (в форме гидрохлорида) 100 мг, вспомогательные вещества: натрия дисульфит -6 мг, динатрия эдетат -0,02 мг. Кроме антибактериального действия, оказываемого Доксициклином, данное вещество, согласно Национальным клиническим рекомендациям по торакальной хирургии, является препаратом выбора для химического плевродеза [10][11][12]. Выведение из эксперимента проводили на 10-е, 20-е и 30-е сутки эксперимента.…”

Section: дизайн исследованияunclassified

Complex Biostimulation of Intrapleural Adhesiogenesis in Thoracal Surgery

Калашніков

Воробьев

Kalashnikova

et al. 2020

Farm. farmakol. (Pâtigorsk)

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The aim of the study is to determine the effectiveness of the use of platelet enriched plasma in the complex treatment of chest trauma and chronic pleural empyema.Materials and methods. The work was performed on 450 male rats, simulated with chest trauma (n=180) and chronic pleural empyema (n=270). In the experimental groups, biostimulation of adhesiogenesis as an intrapleural injection of 1 ml of platelet-enriched plasma was carried out; in the comparison group; the animals with pleural empyema were injected with 1 ml of doxycycline solution; in the negative control groups, the treatment was not carried out at all. Withdrawal from the experiment took place on the 10th, 20th, 30th days. The samples of intrapleural adhesions were fixed in 10% formalin, followed by histological tracing and preparation of micropreparations, staining with hematoxylin and eosin. The morphometric study included determination of the volume fraction (VF) of collagen and reticular fibers; fibrin; inflammatory cells; blood-stream (%).Results. An intrapleural administration of platelet-rich plasma is an effective way to stabilize the rib cage in chest injuries, and to eliminate residual cavities in chronic pleural empyema. When assessing the severity of the adhesions in chest trauma, it was found out that adhesions are most often visualized at the sites of rib fractures (from 13.3 to 40%). In pleural empyema, during the entire process of observation, the VF of collagen fibers forming adhesions was higher in the group with biological stimulation of adhesiogenesis than in the NCpe group and in the CG. In the PRP group, already at the initial stages of the experiment, this indicator was significantly lower than in the NC and CG (p<0.05).Conclusion. Based on the data obtained, the effectiveness of the use of platelet-enriched plasma in thoracic surgery for the biological potentiation of adhesiogenesis has been proved in experimental chest injuries and chronic pleural empyema.

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A randomized controlled trial comparing indwelling pleural catheters with talc pleurodesis (NVALT-14)

Cited by 49 publications

References 14 publications

Success rate of medical thoracoscopy and talc pleurodesis in malignant pleurisy: A single‐centre experience

Success rate of medical thoracoscopy and talc pleurodesis in malignant pleurisy: A single‐centre experience

Intractable pleural effusion in Kaposi sarcoma following antiretroviral therapy in a Caucasian female infected with HIV

Complex Biostimulation of Intrapleural Adhesiogenesis in Thoracal Surgery

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