A randomized controlled trial comparing the efficacy of intralesional 5-fluorouracil versus triamcinolone acetonide in the treatment of keloids

Prabhu, Avinash; Sreekar, Harinatha; Powar, Rajesh; Uppin, V.M.

doi:10.4103/0974-5009.96466

Cited by 16 publications

(25 citation statements)

References 12 publications

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“…Intralesional corticosteroids alone represent one of the most important therapeutic tools for keloids and hypertrophic scars (Juckett & Hartman-Adams 2009, Monstrey et al, 2014. Although intralesional injection of triamcinolone has shown an initial 50-100% efficacy for the treatment of keloids, recurrences are not insignificant (Prabhu, Sreekar, Powar, et al, 2012, Jalali & Bayat 2007, Uyesugi et al, 2010. Although adjuvant irradiation appears to be most efficacious, alternative therapeutic options are needed for young patients or those without access to radiation centers.…”

Section: Discussionmentioning

confidence: 99%

Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study

Rasaii

Sohrabian

Gianfaldoni

et al. 2019

Dermatologic Therapy

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Cutaneous injury can ignite excessive fibroproliferative growth that results in keloid formation. Keloids are associated with significant morbidity related to disfigurement and/or symptoms (e.g., pain and pruritus). First‐line treatment of formed keloids involves topical or intralesional steroids. Recurrent or resistant keloids are managed by surgical excision or cryotherapy, followed by steroidal application or adjuvant irradiation. Although adjuvant irradiation appears to be most efficacious, alternative therapeutic options are needed for patients without access to radiation centers. Botulinum Toxin A (BTA) appears to have similar inhibitory effects to irradiation on the cell cycle via downregulation of pathogenic cytokines. Herein, we conducted a study to compare the efficacy of intralesional triamcinolone used alone, or in combination with BTA, in the treatment of formed keloid scars. Twenty patients with a cumulative of 40 keloids completed the study. There was no significant difference between treatment arms with respect to height vascularization, pliability, and pigmentation scores. The addition of BTA resulted in significant symptomatic improvement of pain and pruritus as compared to intralesional triamcinolone alone (p < 0.001). Irradiation is only effective when administered in the adjuvant setting where inhibitory effects on cell cycle and migration are optimized. Future studies with intralesional triamcinolone and BTA should be performed adjuvantly.

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Section: Discussionmentioning

confidence: 99%

Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study

Rasaii

Sohrabian

Gianfaldoni

et al. 2019

Dermatologic Therapy

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“…Interestingly, good to excellent flattening of keloid size was seen in 64% of patients in patients receiving 5-FU versus 87% in patients receiving TAC monotherapy, and the difference was statistically significant. More complications were encountered in the 5-FU group and included ulceration in one patient, pruritus in one patient, and pain in one patient, but this distinction was not statistically significant [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Comprehensive Review of the Literature

Shah

Aldahan

Mlacker

et al. 2016

Dermatol Ther (Heidelb)

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Hypertrophic (HTSs) and keloid scars are common dermatological complaints produced by disruption of the normal wound-healing process. Despite a wide array of therapeutic options available to treat these lesions, HTSs and keloids continue to pose a significant challenge to clinicians in everyday practice. The chemotherapeutic drug 5-fluorouracil (5-FU) is a well-known treatment option reserved for recalcitrant HTSs and keloid lesions. We present clinicians with a comprehensive review of the published data concerning the use of 5-FU in the treatment of HTSs and keloids. The current evidence suggests that 5-FU is a safe and practical alternative for the treatment of HTSs and keloids as it may substantially improve the appearance of proliferative scars and reduce the chance of recurrence. This therapeutic option is most effective in conjunction with adjuvant therapy such as corticosteroids. Additional randomized controlled clinical trials with large sample sizes should be conducted to corroborate the existing efficacy and safety data in patients with HTSs and keloids.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-016-0118-5) contains supplementary material, which is available to authorized users.

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“…There is no universally accepted treatment resulting in permanent ablation of these scars [6]. Because of the high recurrence rate, a variety of treatments have been developed, including compression therapy, intralesional corticosteroid injections, 5-fluorouracil, methotrexate, bleomycin, radiation, cryosurgery, laser therapy, tamoxifen, and tacrolimus [7].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Triamcinolone Injection in Keloid

Ayad

Shaker

Sarhan

et al. 2022

JAMMR

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Background: A keloid scar is characterised by the production of type III (early) or type I (late) collagen. The goal of this study was to see how effective intralesional triamcinolone acetonide was in treating Keloids from a clinical and microscopic standpoint. Methods: This prospective study included 40 patients diagnosed clinically and histologically with Keloid. Patients were given intralesional injection of triamcinolone (40mg / ml) and each 1 cm2 of keloid was injected by 0.3 ml of the solution for one session monthly for five subsequent sessions. Patients were subjected to full history taking, clinical examination [general and dermatological], digital photography of the lesions and tissue punch biopsies. Results: Before treatment: Normal pigmentation occurred in 36(90.0%) and hyper pigmentation occurred in 4(10.0%). After treatment: Normal pigmentation occurred in 32(80.0%), hyper and hypo pigmentation occurred in 4(10.0%). Colour, itching, pliability and surface area were insignificantly different before and after treatment. Conclusions: The triamcinolone injection was to be promising and long lasting for the suppression of symptoms related to keloids and hypertrophic scars.

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A randomized controlled trial comparing the efficacy of intralesional 5-fluorouracil versus triamcinolone acetonide in the treatment of keloids

Cited by 16 publications

References 12 publications

Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study

Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study

5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Comprehensive Review of the Literature

Efficacy and Safety of Triamcinolone Injection in Keloid

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