A randomized controlled study of three targets of propofol plasma concentration in patients undergoing uterine dilation and curettage

Abstract

Propofol infusion at the target concentration of 5 microg/mL was recommended for uterine dilation and curettage when it was administered with fentanyl 1 microg/kg and nitrous oxide 66% under close monitoring and appropriate respiratory management.

Prevention of nausea and vomiting during termination of pregnancy

“…The incidence of PONV is reported to be less for patients receiving propofol than for those receiving sevoflurane, an inhalational agent, for maintenance of anesthesia [11,12]. Moreover, Uerpairojkit et al [32] compared the efficacy of 3 plasma concentrations of propofol, 4, 5, and 6 μg/mL, in women undergoing uterine dilation and curettage, and recommended the 5-μg level to impede gross movement while preventing PONV. Although the exact mechanisms by which propofol acts as an antiemetic are not known, its antiemetic properties are not a result of the lipid emulsion of its formulation; rather, propofol is thought to be a vagolytic [33,34].…”

Tramadol versus fentanyl during propofol‐based deep sedation for uterine dilatation and curettage: A prospective study

“…Propofol, 2,6‐diisopropylphenol is one of the most popular intravenous sedative‐hypnotic agents used during D&C procedures because of its pharmacokinetic and pharmacodynamic properties. These result in rapid onset and offset of the drug's effects and relatively benign side‐effects . Recovery from propofol should occur within minutes and is generally marked by a sense of well‐being…”

“…These result in rapid onset and offset of the drug's effects and relatively benign side-effects. [7][8][9] Recovery from propofol should occur within minutes and is generally marked by a sense of well-being. 7 Although propofol seems a nearly ideal sedative agent for D&C procedures, its poor analgesic properties necessitate additional analgesic medication.…”

Beyond cells – The virome in the human holobiont

“…By the end of the 20 th century, new scientific advances managed to overcome the need to culture microbes, a crippling constraint that had become a major challenge for microbial ecology. Recombinant DNA techniques developed during the early 70s allowed the cloning of target DNA by inserting it into a plasmid or viral vector, then loading it into culturable bacteria for copying, and finally harvesting the cloned inserts [54, 55]. The resulting high concentrations of pure DNA species were particularly suitable for the assessment of genetic markers such as rRNA profiling [56], the development of DNA probes for research and diagnostics [57], and eventually, for whole genome sequencing using a shotgun approach (consisting on fragmenting, cloning and sequencing a genome, then assembling the sequences together in a procedural manner) [58].…”