Prevention of nausea and vomiting during termination of pregnancy

Fujii, Yoshitaka

doi:10.1016/j.ijgo.2010.05.007

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…Although the frequency and severity of PONV were comparable between the two groups, PONV constitutes a common problem with the termination of pregnancy. The high incidence of PONV may be associated with the emotional state of the patient, the oxytocic agent used, and the type of the anesthetic technique [ 31 ]. In addition, patients in the nalbuphine group with a higher degree of satisfaction may be attributed to a smaller propofol injection and postoperative pain.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Analgesic Effects between Nalbuphine and Sufentanil in First-Trimester Surgical Abortion: A Randomized, Double-Blind, Controlled Trial

et al. 2021

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Introduction: Surgical abortion is one of the commonly conducted procedures worldwide. Nevertheless, pregnant women still complain of procedural and postoperative pain despite the use of advanced anesthesia. It is vital to women's reproductive healthcare to improve postsurgical pain management to achieve the lowest level of pain. Methods: This randomized, double-blind, parallel-controlled clinical trial compared the analgesic effects between nalbuphine and sufentanil in patients who underwent first-trimester surgical abortion. In total, 224 patients were allocated randomly into (a) the sufentanil group that received sufentanil (0.1 ug/kg) combined propofol, and (b) the nalbuphine group that received nalbuphine (0.1 mg/kg) combined propofol. Postoperative pain scores, propofol injection pain, intraoperative analgesic effect, adverse events, and degree of satisfaction were recorded as outcome measures. Results: The pain scores in the nalbuphine group were lower than those in the sufentanil group at 15 min, 30 min, 1 h, and 6 h after surgical abortion. In addition, the incidence and intensity of propofol injection pain were lower in the nalbuphine group. The degree of satisfaction of the patients in the nalbuphine group was higher than that in the sufentanil group. The intraoperative analgesic effect, hemodynamic fluctuation, and adverse events were comparable between the two groups. Conclusions: Nalbuphine combined with propofol is superior to sufentanil combined with propofol for first-trimester abortion surgeries. Clinical Trial Registration: The trial was registered at www.chictr.org.cn, identifier ChiCTR2000040243.

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Section: Discussionmentioning

confidence: 99%

Comparison of Analgesic Effects between Nalbuphine and Sufentanil in First-Trimester Surgical Abortion: A Randomized, Double-Blind, Controlled Trial

et al. 2021

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“…Postoperative nausea and vomiting (PONV) is one of the most common complaints following anesthesia and serious complications of clinical concern in the postoperative period [1,2]. It is often associated with increased morbidity of postoperative bleeding, wound dehiscence, pulmonary aspiration of gastric contents, fluid and electrolyte imbalance, dehydration, delayed hospital discharge, unexpected hospital admission, and decreased satisfaction in surgical patients [3].…”

Section: Introductionmentioning

confidence: 99%

Ramosetron for the prevention of postoperative nausea and vomiting (PONV): a meta-analysis

Kim

Koo

Kim

et al. 2011

Korean J Anesthesiol

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BackgroundPostoperative nausea and vomiting (PONV) remains a challenge for patients and health professionals despite various newly developed prophylactic interventions. We reviewed the efficacy and safety of ramosetron in randomized controlled trials (RCTs) for the prevention of PONV.MethodsWe reviewed 18 randomized controlled trials investigating the efficacy and safety of ramosetron in comparison with placebo or any other drugs. Relevant studies were searched in the MEDLINE, SCOPUS, and the Cochrane database libraries. Our end points of concern were prevention of PONV and adverse effects as dichotomous data.ResultsThe prophylactic effect of 0.3 mg ramosetron was observed in early PON (relative risk, RR: 0.4; 95% CI 0.3-0.6), early POV (RR: 0.3; 95% CI 0.1-0.6), late POV (RR: 0.3; 95% CI 0.1-0.6), but not late PON (RR: 0.7; 95% CI 0.5-1.0). Compared with placebo, the efficacy of 0.3 mg ramosetron in adults and 6 µg/kg in children were consistently beneficial in preventing PONV overall (RR: 0.4; 95% CI: 03-0.6). The effects of 0.3 mg ramosetron and 3 mg granisetron were similar. No serious side effects or adverse events resulted from ramosetron and other active drugs, and incidence was similar to those of the placebo group.ConclusionsRamosetron is effective and safe in children and adults without serious adverse effects compared with placebo or other active drugs, as shown in pooled data of RCTs, in terms of the prevention of PONV.

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“…Metoclopramide is a hyperprolactinemic drug that is used as an antiemetic agent 4,5. In female mice, metoclopramide-induced hyperprolactinemia causes changes in the reproductive system, mainly in ovarian function and the endometrium 6-10.…”

Section: Introductionmentioning

confidence: 99%

Effects of metoclopramide on the mouse anterior pituitary during the estrous cycle

Gomes

Verna

Simões

et al. 2011

Clinics

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Prevention of nausea and vomiting during termination of pregnancy

Abstract: All antiemetics used in the last 20 years to prevent PONV are effective (some more than others) in women undergoing dilatation and curettage for pregnancy termination. However, there is a need for benefit and risk analyses of the different treatments.

Cited by 6 publications

References 39 publications

Comparison of Analgesic Effects between Nalbuphine and Sufentanil in First-Trimester Surgical Abortion: A Randomized, Double-Blind, Controlled Trial

Comparison of Analgesic Effects between Nalbuphine and Sufentanil in First-Trimester Surgical Abortion: A Randomized, Double-Blind, Controlled Trial

Ramosetron for the prevention of postoperative nausea and vomiting (PONV): a meta-analysis

Effects of metoclopramide on the mouse anterior pituitary during the estrous cycle

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