A randomized controlled clinical trial investigating the effect of DASH diet on insulin resistance, inflammation, and oxidative stress in gestational diabetes

Asemi, Zatollah; Samimi, Mansooreh; Tabassi, Zohreh; Sabihi, Sima-Sadat; Esmaillzadeh, Ahmad

doi:10.1016/j.nut.2012.11.020

Cited by 136 publications

(173 citation statements)

References 49 publications

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“…A previous study of ours found the DASH eating pattern to have desirable effects on MetS and its features in this population [10]. Consumption of the DASH diet has also been shown to favorably influence systemic inflammation in adults with MetS [18] or diabetes [19] as well as pregnant women with gestational diabetes [22]. Another study has reported a 14% reduction in serum hs-CRP levels in normotensive and hypertensive adults by adherence to a high-fiber DASH diet [21].…”

Section: Discussionmentioning

confidence: 93%

“…Nowadays, it is assumed that the overall diet rather than individual nutrients or foods affects inflammation [17]. Although several studies have reported the impact of dietary patterns on inflammation, the effect of the DASH diet has been tested in only a few reports [18,19,20,21,22]. A previous study of ours found the DASH eating pattern to have desirable effects on MetS and its features in this population [10].…”

Section: Discussionmentioning

confidence: 99%

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The Dietary Approaches to Stop Hypertension (DASH) Diet Affects Inflammation in Childhood Metabolic Syndrome: A Randomized Cross-Over Clinical Trial

Saneei¹,

et al. 2014

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Background: The effects of the DASH (Dietary Approaches to Stop Hypertension) diet on inflammation in childhood metabolic syndrome (MetS) have still to be identified. Objective: To examine the effects of the DASH diet on markers of systemic inflammation in adolescents with MetS. Methods: In this randomized, cross-over clinical trial, 60 postpubescent girls with MetS were randomly assigned to receive either the DASH diet menu cycles or usual dietary advice (UDA) for 6 weeks. After a 4-week washout period, participants were crossed over to the alternate arm. The DASH diet was designed to maintain the current body weight. This diet contained high amounts of fruit, vegetables and low-fat dairy products and was low in saturated fats and cholesterol. UDA consisted of general oral advice and written information about healthy food choices based on the Healthy Eating Plate. Compliance to the DASH diet was assessed through quantification of plasma vitamin C levels. Fasting venous blood samples were taken 4 times from each participant: at baseline and at the end of each study arm. Circulating levels of biomarkers of systemic inflammation were quantified according to standard protocols. Results: Mean (SD) age and weight of participants was 14.2 years (1.7) and 69 kg (14.5), respectively. Serum vitamin C levels tended to increase during the DASH phase compared with the UDA phase (16.8 ± 12.9 vs. -13.8 ± 9.7 ng/dl, respectively, p = 0.06) indicating a relatively good compliance to the DASH diet. Adherence to the DASH diet, compared to the UDA, had a significant effect on serum high-sensitivity C-reactive protein levels (p = 0.002). This effect remained significant even after adjustment for weight changes and after further controlling for changes in lipid profiles. We did not observe any significant effect of intervention on levels of serum tumor necrosis factor-alpha, interleukin (IL)-2, IL-6 and adiponectin, in either the crude or adjusted models. There were no significant group*time interactions for any dependent variable, except for IL-6; this was close to the significant level. Conclusion: In summary, consumption of the DASH eating pattern for 6 weeks may reduce circulating levels of hs-CRP among adolescents with MetS. Other inflammatory markers were not affected by the DASH diet.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

The Dietary Approaches to Stop Hypertension (DASH) Diet Affects Inflammation in Childhood Metabolic Syndrome: A Randomized Cross-Over Clinical Trial

Saneei¹,

et al. 2014

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“…In addition, GDM is associated with increased risk of adverse maternal and fetal outcomes (5) . Medical nutrition therapy, including use of a lowglycaemic-index diet and the Dietary Approaches to Stop Hypertension (DASH) eating plan (6) , have been suggested for prevention and management of GDM (7) . Beyond lifestyle interventions, Ca or vitamin D supplementation has also been proposed as an approach that could improve pregnancy outcomes in GDM patients (8,9) .…”

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confidence: 99%

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial

Karamali

Asemi

Ahmadi-Dastjerdi

et al. 2015

Public Health Nutr.

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Objective: The present study was designed to assess the effects of Ca + vitamin D supplementation on pregnancy outcomes in women with gestational diabetes mellitus (GDM). Design: A randomized, double-blind, placebo-controlled trial was conducted among sixty women with GDM. Participants were divided into two groups to receive Ca + vitamin D supplements or placebo. Individuals in the Ca + vitamin D group (n 30) received 1000 mg Ca/d and two pearls containing 1250 µg (50 000 IU) of cholecalciferol (vitamin D 3 ) during the intervention (one at study baseline and another at day 21 of the intervention); those in the placebo group (n 30) received two placebos of vitamin D at the mentioned times and placebos of Ca every day for 6 weeks. Pregnancy outcomes were determined. Setting: A urban community setting in Arak, Iran. Subjects: Sixty women with GDM and their newborns, living in Arak, Iran were enrolled. Results: Women treated with Ca + vitamin D had a significant decrease in caesarean section rate (23·3 % v. 63·3 %, P = 0·002) and maternal hospitalization (0 v. 13·3 %, P = 0·03) compared with those receiving placebo. In addition, newborns of GDM women randomized to Ca + vitamin D had no case of macrosomia, while the prevalence of macrosomia among those randomized to placebo was 13·3 % (P = 0·03). Lower rates of hyperbilirubinaemia (20·0 % v. 56·7 %, P = 0·03) and hospitalization (20·0 % v. 56·7 %, P = 0·03) were also seen in the supplemented group of newborns than in the placebo group. Conclusions: Ca + vitamin D supplementation for 6 weeks among pregnant women with GDM led to decreased caesarean section rate and maternal hospitalization, and decreased macrosomia, hyperbilirubinaemia and hospitalization in newborns.

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“…The application in a randomised study of a diet with reduced content of carbohydrates in the group of women with gestational diabetes (40% of energy from carbohydrates in the diet of the study group vs. 55% in the control group) did not result in a decrease in the number of women who needed insulin, nor affected pregnancy outcomes [17]. The subsequent reports showed that the dietary approaches to stop hypertension (DASH) diet applied by women with gestational diabetes had a favourable effect on fasting glucose level, insulin level, and the value of the homeostatic model assessment of insulin resistance (HOMA-IR) index, as well as a decrease in the body weight of newborns, compared to the control group (3,222.7 g vs. 3,818.8 g) [18,19].…”

Section: Gestational Diabetesmentioning

confidence: 99%

Eating habits and nutritional status of pregnant women and the course and outcomes of pregnancy

Suliga¹

2015

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The eating habits and nutritional status of future mothers have an important effect, not only on the course of pregnancy and the development of the foetus, but also on the health of the children during subsequent years of life. The objective of the study was the analysis of the relationship between eating habits and nutritional status of pregnant women on the course of pregnancy and pregnancy outcomes, based on a literature review. In the presented study the following are discussed: nutritional risk factors of pre-term birth, gestational diabetes, preeclampsia, low birth weight, infants born small for gestational age, as well as macrosomia and babies born large for gestational age. In the analysis, data was used concerning the consumption of individual products, groups of products, and dietary patterns, without consideration of dietary supplementation. StreszczenieSposób żywienia i stan odżywienia przyszłych matek mają istotny wpływ nie tylko na przebieg ciąży i rozwój płodu, lecz także na zdrowie ich dzieci w kolejnych latach życia. Celem pracy była analiza zależności między sposobem żywienia i stanem odżywienia kobiet ciężarnych a przebiegiem ciąży i wskaźnikami urodzeniowymi noworodków na podstawie przeglądu piśmiennictwa. W pracy omówiono żywieniowe czynniki ryzyka porodu przedwczesnego, cukrzycy ciążowej, preeklampsji, małej masy urodzeniowej i małej masy w stosunku do wieku płodowego oraz makrosomii i dużej masy w stosunku do wieku płodowego. W analizie wykorzystano dane dotyczące spożycia poszczególnych produktów, grup produktów oraz wzorów żywieniowych bez uwzględniania suplementacji.

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A randomized controlled clinical trial investigating the effect of DASH diet on insulin resistance, inflammation, and oxidative stress in gestational diabetes

Cited by 136 publications

References 49 publications

The Dietary Approaches to Stop Hypertension (DASH) Diet Affects Inflammation in Childhood Metabolic Syndrome: A Randomized Cross-Over Clinical Trial

The Dietary Approaches to Stop Hypertension (DASH) Diet Affects Inflammation in Childhood Metabolic Syndrome: A Randomized Cross-Over Clinical Trial

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial

Eating habits and nutritional status of pregnant women and the course and outcomes of pregnancy

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