A randomized control study for evaluating the efficacy of individualized homoeopathic medicine as an adjuvant therapy in mild to moderate cases of COVID-19

Phansalkar, Shirish Kamlakar; Pacharne, Tejaswini Deoram; Somawanshi, Navnath Hanumant; Parekh, Bhavik

doi:10.25259/jish_15_2021

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…Moreover, this study showed the use of remedies like Arsenicum album, Bryonia alba and Phosphorus in the majority, whereas current study evidences the exceptional effect of Bryonia alba, Tuberculinum bovinum and Arnica montana. Another randomized controlled trial of 50 sample sizes conducted on mild to moderate cases of COVID-19 promises the role of Homoeopathic medicines in relieving subjective as well as objective parameters [37]. Also, prognostic factor research carried out as a multicentric observational study at public health care-clinics, showed the efficacy of homoeopathy in improvement of case of COVID-19 with frequent indications of Arsenicum album, Bryonia alba, Gelsemium sempervirens, and Pulsatilla nigricans [24].…”

Section: Interpretation Of Findings In Relation To Previous Publicati...mentioning

confidence: 99%

Randomised controlled trial to compare efficacy of standard care alone and in combination with homoeopathic treatment of moderate/severe COVID-19 cases

Kaur,

Bawaskar,

Khobragade

et al. 2023

PLoS ONE

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Background & objectives No definite treatment is known for COVID-19 till date. The objective of this study is to assess the efficacy of customized Homoeopathic medicines, when used as an add-on treatment to Standard of Care (SOC), in patients suffering from moderate to severe COVID-19 infection. Methods This was a randomized, controlled, single-blind, parallel-group trial where 214 COVID19-positive patients were screened for moderate and severe cases of COVID-19. Adjuvant homoeopathic medicines were given in the treatment group and SOC was given to both groups. The duration of oxygen support was compared as the primary outcome. Subjects were followed for 28 days or till the end-point of mechanical ventilation/ death. Results Of 129 subjects included, 57 and 55 were severe; and 8 and 9 were moderate cases in Homoeopathy and SOC arms, respectively. In all, 9 (15.2%) participants in Homoeopathy and 20 (32.2%) participants in SOC arms eventually expired (p<0.05). Oxygen support was required for 9.84±7.00 and 14.92±7.549 days in Homoeopathy and SOC arms, respectively (p<0.005). Subjects receiving Homoeopathy (12.9±6.days) had a shorter hospitalization stay than in SOC (14.9±7.5 days). Homoeopathy arm (10.6±5.7 days) also showed statistically significant mean conversion time of of Realtime-Polymerase Chain Reaction (RT-PCR) from positive to negative than the SOC arm (12.9±5.6 days). The mean score of Clinical Outcome Ordinal Scale (COOS) was lower in the Homoeopathy arm. Laboratory markers [Interleukins (IL)-6, C-reactive protein (CRP), Neutrophils-Lymphocytes ratio (NLR)]were normalized earlier in Homoeopathy arm. Conclusion Homoeopathy, as add-on therapy with SOC for COVID-19 management, demonstrates a reduction in mortality and morbidity, by reduced requirement of oxygen and hospitalization. Some laboratory markers are normalized at an earlier time. Hence, there is overall control over the disease. Registry: The study was registered on the http://ctri.nic.in/Clinicaltrials website under identifier number: CTRI/2020/12/029668 on 9th December 2020.

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Section: Interpretation Of Findings In Relation To Previous Publicati...mentioning

confidence: 99%

Randomised controlled trial to compare efficacy of standard care alone and in combination with homoeopathic treatment of moderate/severe COVID-19 cases

Kaur,

Bawaskar,

Khobragade

et al. 2023

PLoS ONE

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“…27 Homeopathy, which works on principles of similar symptomatology of disease and drug, individualization of therapy and hyper-attenuated prescriptions, requires a special research method. [28][29][30] Various publications have tried registry and randomized trial-based evidence of the efficacy of individualized homeopathic medicines or genus epidemicus in different ways, either as a standalone therapy or as an adjuvant. 31 With an emerging acceptance in population despite anecdotal criticism by perpetually repudiating experts, there is still a pronounced need for organized efforts to establish the safety and effectiveness of homeopathy in COVID-19 patients, scientifically.…”

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confidence: 99%

Homeopathic treatment of COVID-19 caused by novel coronavirus SARS CoV2-a real-world experience

Arora¹,

Indani²,

Goyal

et al. 2022

Int J Adv Med

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Background: The unprecedented healthcare challenge of COVID-19 uncovered a new set of challenges for therapy and management of infective conditions. The aim of the study was to established efficacy and safety homoeopathic medicines, which works on principles of similar symptomatology of the disease and the drug, individualization of therapy and hyper-attenuated prescriptions.Methods: The present study was a single centre, OPD based, prospective real-world, all-comer study that included 94 patients of COVID-19, diagnosed based on criteria advised by the Ministry of AYUSH).Results: In all, 94 all-comer, real-world patients of COVID-19 were included in the study, diagnosed on this basis of the MoH guidance criteria. All patients were symptomatic. The overall age of the patients was 40.98 ±19.98 years. Few patients [n=21 (16.84)] had comorbidities while a majority of patients [n=79 (83.16%)] had no notable comorbidity. All the patients were relieved to be asymptomatic in maximum 6 days. In the reversed calculation of Cohen’s D, indicated that the effect of therapy was significantly large. However, pertaining to the data volume, the effect size was not statistically significant. Conclusions: Individualized homeopathic medicine were effective in treatment of COVID-19. However, Bryonia alba and arsenic album were most commonly indicated medicines p overall <0.0001 (Chi square for equal distribution of top 10). Another trend observation established that Bryonia alba was most commonly indicated and effective medicine; hence a potential homeopathic medicine for epidemic (genus: Epidemicus).

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Research in Homoeopathy: Building a base using quality evidence

Jani¹

2022

JISH

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A randomized control study for evaluating the efficacy of individualized homoeopathic medicine as an adjuvant therapy in mild to moderate cases of COVID-19

Cited by 6 publications

References 9 publications

Randomised controlled trial to compare efficacy of standard care alone and in combination with homoeopathic treatment of moderate/severe COVID-19 cases

Randomised controlled trial to compare efficacy of standard care alone and in combination with homoeopathic treatment of moderate/severe COVID-19 cases

Homeopathic treatment of COVID-19 caused by novel coronavirus SARS CoV2-a real-world experience

Research in Homoeopathy: Building a base using quality evidence

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