A Randomized Comparison of the Effect of Two Diuretics, a Converting Enzyme Inhibitor, and a Sympathomimeticamine on Weight Loss in Diet-Refractory Patients

Check, Jerome H.; Shanis, Bonnie S.; Shapse, Deborah; Adelson, Harriet G.

doi:10.4158/ep.1.5.323

Cited by 17 publications

(21 citation statements)

References 7 publications

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“…Thus the clinical conditions that result from the defect are not severe enough until compromised by further decrease in sympathetic tone that may occur in the mid to late luteal phase. The increased cellular permeability syndrome is known to cause edema and weight gain by not allowing sufficient sympathetic signals to the capillaries to diminish capillary permeability in response to the increase in hydrostatic pressure that occurs in the erect position [16]. This mechanism could explain the well known phenomenon of premenstrual edema.…”

Section: Discussionmentioning

confidence: 99%

Use of sympathomimetic amines to correct premenstrual urticaria and anaphylaxis

Check¹

2019

Clin. Exp. Obstet. Gynecol.

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Purpose: To see if the use of sympathomimetic amines, which have been shown to treat cases of hives, can help prevent cyclical urticaria and anaphylaxis associated with the late luteal phase that was resistant to standard treatment. Materials and Methods: Treatment with low dose dextroamphetamine sulfate to gain relief of symptoms was given to one young woman whose urticaria only occurred premenstrually, but was also associated with life threatening anaphylaxis. Patient 2 had chronic daily urticaria which was exacerbated premenstrually. Results: Both patients showed prompt 100% improvement in the urticaria. Patient 2 after 20 years of therapy ran out of medication for one month. Her severe urticaria quickly returned only to dissipate when dextroamphetamine sulfate was restarted. Conclusion: Use of dextroamphetamine sulfate was successful in treating the anaphylaxis and extensive luteal phase hives in patient 1 as well as treating chronic hives with a premenstrual exacerbation in patient 2. These cases are both consistent with the proposed mechanism of the sympathetic neural hyperalgesia edema syndrome, i.e., increased cellular permeability related to sympathetic nervous system hypofunction of specific permeability defects of certain tissues. In these cases, the hypothesis is that the increased permeability manifests as leakage from the vesicles that contain the histamines.

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Section: Discussionmentioning

confidence: 99%

Use of sympathomimetic amines to correct premenstrual urticaria and anaphylaxis

Check¹

2019

Clin. Exp. Obstet. Gynecol.

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“…The only other manifestation of the increased cellular permeability syndrome was edema of her ankles and fingers [5,16]. She had noted, probably related to the edema that she had trouble losing weight despite dieting and moderate exercise [16].…”

Section: Case Reportmentioning

confidence: 99%

“…Her initial weight for this 60 inch woman was 122 pounds. Associated with the abrogation of the edema was an 11 pound weight loss [16]. She is no longer dieting.…”

Section: Case Reportmentioning

confidence: 99%

A novel effective treatment for menière’s disease – dextroamphetamine sulfate

2020

Clinical and Experimental Obstetrics & Gynecology

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To determine if treatment with dextroamphetamine sulfate could ameliorate the symptoms of long-standing Menière's disease in a menopausal woman with a past history of dysmenorrhea. Methods: Dextroamphetamine sulfate was started at 9.4 mg extended release tablets and eventually increased to 18.8 mg (Adzenys®). Results: The symptoms of constant ear fullness and severe tinnitus abated and have not returned for 2 years. In addition, the edema of the fingers and ankles have abated along with an 11 pound weight loss. Conclusions: Menière's disease can be added to the long list of chronic treatment resistant conditions lumped together under the name of the increased cellular permeability syndrome. This syndrome may or may not be associated with pelvic pain. The common denominator is that these seemingly unrelated conditions affecting many organ systems all respond markedly well to amphetamine therapy. The hypothesis of the efficacy of dextroamphetamine sulfate is that it releases dopamine from sympathetic nerve fibers, which, in turn, diminishes cellular permeability.

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“…The authors advised the child and her mother that they believed she had hypofunction of the sympathetic nervous system syndrome otherwise known as the sympathetic neural hyperalgesia edema syndrome. This would explain the weight gain and could explain the vulvar and vaginal severe irritation and discomfort [5]. Thus they suggested that her inability to focus in school and possibly the reason for her recent drop from a top student to mediocre could be related to attention deficient hyperactivity disorder (ADHD) (though in her case lacking the hyperactivity).…”

Section: Case Reportmentioning

confidence: 99%

Marked improvement of vulvovaginitis of unknown origin in a pediatric patient - case report

Check

Cohen²

2014

Clin. Exp. Obstet. Gynecol.

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To present a novel therapy for pediatric vulvovaginitis. Materials and Methods: An eight-year-old girl with persistent severe vulvovaginitis of unknown origin also complained of unexplained weight gain and sudden academic difficulties. She was treated with dextroamphetamine sulfate. Results: She not only showed very quick and excellent relief from her vulvovaginitis but she also lost weight and improved her mentality. Conclusions: Sympathomimetic amine therapy may benefit pediatric vulvovaginitis when an infectious cause cannot be ascertained.

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A Randomized Comparison of the Effect of Two Diuretics, a Converting Enzyme Inhibitor, and a Sympathomimeticamine on Weight Loss in Diet-Refractory Patients

Cited by 17 publications

References 7 publications

Use of sympathomimetic amines to correct premenstrual urticaria and anaphylaxis

Use of sympathomimetic amines to correct premenstrual urticaria and anaphylaxis

A novel effective treatment for menière’s disease – dextroamphetamine sulfate

Marked improvement of vulvovaginitis of unknown origin in a pediatric patient - case report

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