A randomized clinical trial of magnesium sulphate as a vehicle for nebulized salbutamol in the treatment of moderate to severe asthma attacks

The role of magnesium sulfate in the intensive care unit

“…Life-threatening conditions like severe asthma attacks require intensive medical care. The beneficial effects of MgSO 4 have been shown in children and adult patients with severe asthma in the ICU (Boonyavorakul et al, 2000[16]; Daengsuwan and Watanatham, 2016[31]; Griffiths and Kew, 2016[52]; Kew et al, 2014[77]; Kokturk et al, 2005[83]; Rowe, 2013[128]; Rowe and Camargo, 2008[129]; Rower et al, 2017[130]; Singh et al, 2008[143]).…”

“…Use of MgSO 4 through intravenous route in adult and children patients improves respiratory function (Boonyavorakul et al, 2000[16]; Daengsuwan and Watanatham, 2016[31]; Griffiths and Kew, 2016[52]; Kew et al, 2014[77]; Kokturk et al, 2005[83]; Rowe, 2013[128]; Rowe and Camargo, 2008[129]; Rower et al, 2017[130]; Singh et al, 2008[143]). In some countries, the intravenous form of MgSO 4 is broadly used as an adjunctive therapy for severe acute asthma, especially in patients not responding to initial treatments (British Thoracic Society Scottish Intercollegiate Guidelines, 2008[20]; Jones and Goodacre, 2009[74]).…”

“…However, in contrast to intravenous MgSO 4 , the effect of the inhaled form remains controversial. Up to 500 mg MgSO 4 for each dose of nebulization has been used in several clinical trials (Aggarwal et al, 2006[3]; Ahmed et al, 2013[4]; Bessmertny et al, 2002[13]; Chande and Skoner, 1992[24]; Gallegos-Solorzano et al, 2010[43]; Gandia et al, 2012[44]; Hill et al, 1997[62]; Hughes et al, 2003[65]; Kokturk et al, 2005[83]; Mangat et al, 1998[98]; Nannini and Hofer, 1997[116]; Nannini et al, 2000[117]; Rolla et al, 1987[126]; Zandsteeg et al, 2009[173]). Respiratory functions and hospital admission were assesed in all studies and, similar to intravenous MgSO 4 therapy, β-agonists and corticosteroids were used in all patients (Aggarwal et al, 2006[3]; Ahmed et al, 2013[4]; Chande and Skoner, 1992[24]; Gandia et al, 2012[44]; Hill et al, 1997[62]; Mangat et al, 1998[98]; Nannini and Hofer, 1997[116]; Nannini et al, 2000[117]; Rolla et al, 1987[126]; Zandsteeg et al, 2009[173]).…”

Uso do sulfato de magnésio por via venosa e nebulização para o tratamento da asma aguda na emergência

“…Em 58% dos participantes ocorreu o aparecimento de efeitos adversos menores: fadiga moderada, sensação de calor corporal, rubor e urticária nos membros superiores. Kokturk e col. 24 em ensaio clínico aleatorizado com pacientes adultos utilizando o magnésio (2,5 mL a 6,3%) como veículo para nebulização do salbutamol. Os pacientes foram divididos em dois grupos.…”

Efficacy of nebulized magnesium sulfate in the treatment of acute exacerbation of asthma in children

“…On the contrary, data on nebulized magnesium sulfate have been scant. The effect of nebulized magnesium sulfate as a vehicle for salbutamol has been less evaluated (Kokturk et al, 2005). In pediatric population this type of study is very rare.…”