A randomized clinical trial evaluating a proprietary mixture of Lactobacillus plantarum strains for lowering cholesterol1

Fuentes, Mari Carmen; Lajo, Teresa; Carrión, Juan M.; Cuñé, Jordi

doi:10.3233/mnm-160065

Cited by 27 publications

(31 citation statements)

References 54 publications

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“…There into, 5 articles can be viewed as multiple studies. There are studies that applied more than one intervention times so can be regarded as multiple independent studies, which include Sadrzadeh-Yeganeh et al's [ 18 ] study (2), Jones et al's study [ 23 ] (2), Fuentes et al's study [ 24 ] (2), Fuentes et al's study [ 38 ] (3). Another study used 2 different delivery methods of milk or yogurt by Ivey et al, [ 31 ] which can also be considered as 2 independent studies.…”

Section: Resultsmentioning

confidence: 99%

The effects of probiotics on total cholesterol

Wang

Guo²,

Gao³

et al. 2018

Medicine

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Background:Probiotics supplements provide a new nonpharmacological alternative to reduce cardiovascular risk factors. The impact of probiotics on the reduction of total cholesterol (TC) remains controversial. We conducted a meta-analysis to showcase the most updated and comprehensive evaluation of the studies.Methods:Randomized controlled trials (RCTs) were searched from electronic databases, including PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang database dating from January 2007 to January 2017. The curative effects of probiotics on the reduction of TC were assessed using mean difference (MD), as well as their 95% confidence interval (CI). RevMan software (version 5.3) was used to carry out this meta-analysis.Results:Thirty-two RCTs including 1971 patients met the inclusion criteria. Results of this analysis showed that compared with the control group serum TC was significantly reduced in probiotics group [MD = −13.27, 95% CI (−16.74 to 9.80), P < .05]. In addition, specific strains also significantly reduced serum TC, L acidophilus and B lactis [MD = −8.30, 95% CI (−10.44, −6.15), P < .05]; VSL#3 [MD = −11.04, 95% CI (−19.61, −2.48), P < .05]; L plantarum t ≤ 6 weeks: [MD = −1.56, 95% CI (−6.97, −3.86), P < .05] or t > 6 weeks: [MD = −22.18, 95% CI (−28.73, −15.63), P < .05]. Subgroup analysis indicated that the difference of baseline TC, probiotics forms and intervention duration might have a significant impact on the results. However, strains and doses of probiotics had no significant influence on curative effects.Conclusion:Available evidence indicates that probiotics supplements can significantly reduce serum TC. Furthermore, higher baseline TC, longer intervention time, and probiotics in capsules form might contribute to a better curative effect.

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Section: Resultsmentioning

confidence: 99%

The effects of probiotics on total cholesterol

Wang

Guo²,

Gao³

et al. 2018

Medicine

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“…27 The intervention of L. plantarum strain mixture, in the form of a capsule, for 12 weeks effectively reduced the total cholesterol, LDL-C, LDL-D/HDL-C ratio, and triglyceride levels in hypercholesterolemic subjects. 28 Although, the meta-analysis of several randomized controlled clinical trials suggested that the supplementation of probiotic formulations decreased the triglycerides, LDL-C, and total cholesterol, and increased the HDL-C content when compared to the placebo control and baseline values. 29,30 It is the truth that not all the probiotic interventions improved the lipid profile and other related parameters in human volunteers.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus paracasei HII01 on lipid profile and blood parameters in hypercholesterolemic patients: A preliminary study

et al. 2020

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Background: Probiotics are live microbes that when administered in suitable amounts, confer a health benefit on the host. Probiotics are considered as a complementary and supportive therapeutic agent for the treatment of several diseases and for the management of several disorders. Hypercholesterolemia is a major risk factor for the incidence of cardiovascular (CV) diseases. Several pharmacological and dietary approaches are proposed and used to improve the cholesterol profile. Aims and Objective: The objective of the current study was to study the effect of probiotic supplementation (Lactobacillus paracasei HII01) on high-density lipoprotein (HDL), and low-density lipoprotein (LDL), lipopolysaccharide (LPS), and immunoglobulin A (IgA) levels in hypercholesterolemic patients. Materials and Methods: Ten hypercholesterolemic subjects were supplemented with 12.5 × 109 CFU of HII01 per day for 12 weeks. Blood samples were collected at baseline and after the intervention period. The LDL-C, HDL-C, LPS, and IgA content were assessed by outsourcing and ELISA methods. Results: After 12 weeks of intervention, HDL (from 61.14 ± 9.65 to 67.29 ± 7.99 mg/DL), LDL (from 141.57 ± 31.95 to 126.29 ± 36.23 mg/DL), IgA (446.31 ±262.00 to 939.62 ± 758.52 ng/ml), and LPS (113.53 ± 40.07 to 72.78 ± 32.39 pg/ml) levels were significantly changed in the probiotic-supplemented group when compared to the baseline value. Conclusion: The supplementation of L. paracasei HII01 may help to improve the lipid profile, reduce the endotoxin level and have the impact of immune activation in hypercholesterolemic subjects. Additional studies are mandatory to disclose the favorable effect of the probiotic strain L. paracasei HII01.

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“…A 12-week supplementation of a mixture of L. plantarum strains (CECT 7528, CECT 7529, CECT 7527; 10 10 CFU/day) significantly increased the level of HDL-C and reduced LDL-C, TC, triglycerides (TG), LDL-C/HDL-C ratio, and oxidized LDL levels in hypercholesterolemic subjects. The results revealed that probiotics could be used for hypercholesterolemia treatment [25].…”

Section: Hypercholesterolemic Subjectsmentioning

confidence: 97%

“…Based on the randomized, placebo-controlled, double-blind studies [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] reviewed in the present article, the hypocholesterolemic effect of the probiotics was not significantly influenced by the diet. Studies reported based on the intervention of single-strain probiotic (E. faecium M-74 along with selenium [27]; Saccharomyces cerevisiae var.…”

Section: Opinion On the Hypocholesterolemic Effect Of Reviewed Probiomentioning

confidence: 99%

“…Studies based on the intervention of multi-genus, multi-species, multi-strain (strains of same species) probiotic preparation has been reported with positive effect on lipid profile [24][25][26]28,[31][32][33][34][36][37][38][39]47,48], while several studies reported no effect of multi-genus and multi-species probiotic intervention on the lipid profile [55][56][57][58][59][60][61][62][63]. Even though intervention of Ecologic ® Barrier (B. bifidum W23, B. lactis W51, B. lactis W52, L. acidophilus W37, L. brevis W63, L. casei W56, L. salivarius W24, Lactococcus lactis W19 and W58) exhibit hypocholesterolemic effect on different subjects (individuals with T2D [38]; obese postmenopausal women [39]) with different intervention duration (six months [38]; 12 weeks [39]), dosage of probiotic mixture does not influence the cholesterol-lowering ability of the probiotic mixture.…”

Section: Opinion On the Hypocholesterolemic Effect Of Reviewed Probiomentioning

confidence: 99%

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A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics

2019

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Cardiovascular diseases (CVD) are the major health issue of modernized society with a high mortality rate. Lifestyle, genetic makeup, and diet are some of the major influencing factors associated with CVD. The dyslipidemia is one such factor related to the development of several CVD. Many studies proved that the consumption of probiotics confers several health benefits. Several studies reported the evaluation of the cholesterol-lowering ability of probiotics (probiotics that showed positive effect in vitro and in vivo studies) in human volunteers. The current review summarizes the outcomes of human studies on the cholesterol-lowering property of probiotics. Probiotic consumption significantly improved the health status of hypercholesteremic patients by reducing the low-density lipoprotein cholesterol, total cholesterol, triglyceride levels, and increased the high-density lipoprotein cholesterol. The probiotic supplementation improved the lipid profile of diabetic patients, and obese people as well. However, not all probiotic interventions are effective against dyslipidemia. The results are controversial and depend on several factors such as probiotic strain, dose, duration of the treatment, lifestyle changes, etc. This literature survey indorses additional studies on the cholesterol-lowering property of probiotics, which could help to reduce the risk of CVD and other dyslipidemia associated health issues.

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A randomized clinical trial evaluating a proprietary mixture of Lactobacillus plantarum strains for lowering cholesterol1

Cited by 27 publications

References 54 publications

The effects of probiotics on total cholesterol

The effects of probiotics on total cholesterol

Effect of Lactobacillus paracasei HII01 on lipid profile and blood parameters in hypercholesterolemic patients: A preliminary study

A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics

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