A randomized clinical trial comparing hydrocolloid, phenytoin and simple dressings for the treatment of pressure ulcers [ISRCTN33429693]

Hollisaz, Mohammad Taghi; Khedmat, Hossein; Yari, Fatemeh

doi:10.1186/1471-5945-4-18

Cited by 57 publications

(62 citation statements)

References 25 publications

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“…In terms of comparisons, it is emphasized that topical phenytoin showed healing potential higher than saline, although lower than hydrocolloid (13) . This fact makes the use of phenytoin as a healing agent attractive to health services devoid of greater resources for the acquisition of high-tech curative materials.…”

Section: Rev Esc Enfermmentioning

confidence: 99%

Scientific production on the applicability of phenytoin in wound healing

Firmino¹,

Almeida

Silva

et al. 2014

Rev. esc. enferm. USP

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RESUmoA fenitoína é um anticonvulsivante que vem sendo empregado na cicatrização de ferida. Os objetivos desta pesquisa foram: descrever como a produção científica apresenta o uso da fenitoína como agente cicatrizante e discutir sua aplicabilidade em feridas. Foi realizada, para tanto, revisão integrativa da literatura e análise pela hierarquia das práticas baseadas em evidências. Assim, analisaram-se 18 artigos que testaram a intervenção em feridas como úlceras de perna, por hanseníase, pé diabético, úlceras por pressão, tróficas, ferimentos de guerra, queimaduras, preparo da área receptora de enxerto, radiodermites e pós-extração de nevos melanocíticos. Uso sistê-mico da fenitoína no tratamento de fístulas e a hipótese do uso tópico no tratamento do vitiligo foram achados. Conclui-se que a fenitoína tópica é uma evidência científica. No entanto necessita-se de pesquisas robustas que sustentem o uso protocolar da fenitoína como mais uma opção de agente cicatrizante na prática clínica. Scientific production on the applicability of phenytoin in wound healing * CritiCal review AbStRActPhenytoin is an anticonvulsant that has been used in wound healing. The objectives of this study were to describe how the scientific production presents the use of phenytoin as a healing agent and to discuss its applicability in wounds. A literature review and hierarchy analysis of evidence-based practices was performed.Eighteen articles were analyzed that tested the intervention in wounds such as leprosy ulcers, leg ulcers, diabetic foot ulcers, pressure ulcers, trophic ulcers, war wounds, burns, preparation of recipient graft area, radiodermatitis and post-extraction of melanocytic nevi. Systemic use of phenytoin in the treatment of fistulas and the hypothesis of topical use in the treatment of vitiligo were found. In conclusion, topical use of phenytoin is scientifically evidenced. However robust research is needed that supports a protocol for the use of phenytoin as another option of a healing agent in clinical practice. dEScRiPtoRS Phenytoin Wound healing Evidence-based nursing Review RESUmEnLa fenitoína es un anticonvulsivo que se utiliza en la cicatrización de heridas. Los objetivos de esta investigación fueron: describir cómo la producción científica presenta el uso de la fenitoína como agente cicatrizante y discutir su aplicabilidad en las heridas. Se realizó una revisión integradora de la literatura y el análisis por la jerarquía de las prácticas basadas en las evidencias. Se analizaron 18 artículos que probaron la intervención en heridas como úlceras en la pierna por hanseniasis, pie diabético, úlceras por presión, tróficas, heridas de guerra, quemadura, preparación de la zona a injertar, radiodermitis y post extracción de nevos melanocíticos. Se encontró el uso sistémico de la fenitoína en el tratamiento de fístulas y la hipótesis del uso tópico en el tratamiento del vitíligo. Se concluye que la fenitoína tópica es una evidencia científica. Sin embargo, se necesita de investigaciones sólidas que sustenten el uso protocola...

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Section: Rev Esc Enfermmentioning

confidence: 99%

Scientific production on the applicability of phenytoin in wound healing

Firmino¹,

Almeida

Silva

et al. 2014

Rev. esc. enferm. USP

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“…Other types of dressing such as hydrocolloid, polyurethane foam, hydropolymer, hydrocellular, and alginate are also used with different advantages and disadvantages [11][12][13]. Conventional dressings require frequent changes which can be painful and may even require anesthesia.…”

mentioning

confidence: 99%

Grafting with Cryopreserved Amniotic Membrane versus Conservative Wound Care in Treatment of Pressure Ulcers: A Randomized Clinical Trial

Dehghani

Azarpira

Karimi

et al. 2017

BEAT

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Objective:To compare the healing process of pressure ulcers treated with cryopreserved human amniotic membrane allograft and routine pressure ulcer care in our hospital. Methods: From January 2012 to December 2013, in a prospective randomized clinical trial (IRCT201612041335N2), 24 patients with second and third stage of pressure ulcers were enrolled in this study. All patients needed split thickness skin grafts for pressure ulcer-wound coverage. Selected patients had symmetric ulcers on both upper and lower extremities. The patients were randomly divided into two groups: amnion and control. In the amnion group, the ulcer was covered with cryopreserved amniotic membrane and in the control group it was treated with local Dilantin powder application. The duration and success rate of complete healing was compared between the two groups. Results: The study group was composed of 24 pressure ulcers in 24 patients (19 males and 5 females) with a mean age of 44±12.70 years. The demographic characteristics, ulcer area, and underlying diseases were similar in both groups. The early sign of response, such as decrease in wound discharge, was detected 12-14 days after biological dressing. Complete pressure ulcer healing occurred only in the amnion group (p<0.001). Partial healing was significantly higher in the amnion group (p<0.03). Healing time in this group was faster than that the control group (20 days versus 54 days). No major complication was recorded with amniotic membrane dressing. Conclusion: Cryopreserved amniotic membrane is an effective biologic dressing that promotes reepithelialization in pressure ulcers.

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“…[11][12][13] Several methods have been used to study healing promotion, but few studies investigated these modalities in comparison to each other. [14][15][16][17][18] In this study we evaluated the effect of low-level laser in wound healing and compared it with phenytoin.…”

mentioning

confidence: 99%