A Randomized Case–Control Study of Dynamic Changes in Peripheral Blood Th17/Treg Cell Balance and Interleukin-17 Levels in Highly Active Antiretroviral-Treated HIV Type 1/AIDS Patients

He, Yan; Li, Jing; Zheng, Yuhua; Luo, Yan; Zhou, Haiyan; Yao, Yihong; Chen, Xia; Chen, Zi; He, Min

doi:10.1089/aid.2011.0140

Cited by 35 publications

(42 citation statements)

References 30 publications

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“…27 After staphylococcal enterotoxin B stimulation, PBMCs from HIV-infected patients showed a normal capacity for intracellular production of IL-17/IL-22 (see Fig E4, B and C, in this article's Online Repository at www.jacionline.org), which was in accordance with previous reports that long-term ART induces normalization of the capacity of T cells to produce IL-17/IL-22. 28,29 More importantly, in the absence of any stimulation, the percentages of IL-17-or IL-22-producing PBMCs were significantly higher in HIV-infected patients than in HCs (Fig 5, B and C). The phenotypic analysis showed that these circulating IL-17 1 and IL-22 1 cells were mainly T helper cells (CD3 1 CD4 1 ; see Fig E4, D).…”

Section: Specific Cytokine Environment In Hiv-infected Patientsmentioning

confidence: 88%

Neutrophils in antiretroviral therapy–controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment

Campillo-Gimenez

Casulli

Dudoit

et al. 2014

Journal of Allergy and Clinical Immunology

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Section: Specific Cytokine Environment In Hiv-infected Patientsmentioning

confidence: 88%

Neutrophils in antiretroviral therapy–controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment

Campillo-Gimenez

Casulli

Dudoit

et al. 2014

Journal of Allergy and Clinical Immunology

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“…[15][16][17] Therefore, we determined the ratios of Th1:Treg, Treg:Th17, and Th1:Th17 of gut-homing CD4 1 T cells in AHIs. Acute HIV-1 infection led to a loss of guthoming Th1:Treg compared to HCs (Figure 6b), and the Treg:Th17 ratio increased in the gut-homing CD4 1 T-cell subset with statistical significance (Figure 6c).…”

Section: Imbalance Of Gut-homing Th1:treg and Treg:th17 Ratios In Acumentioning

confidence: 99%

“…[10][11][12][13][14] Alterations in Th17:Th1 and Th17:Treg balance also contribute to disease progression in HIV/SIV infection. [15][16][17] The gut-homing receptor integrin a4b7 mediates lymphocyte migration from the circulation to the intestine through interaction with MAdCAM-1 on endothelial cells of gut tissues. 18,19 The binding of integrin a4b7 and HIV-1 gp120 facilitates selective infection and replication in a4b7 CD4 1 T cells, which results in HIV-1 cell-to-cell spreading.…”

Section: Introductionmentioning

confidence: 99%

Preferential loss of gut-homing α4β7 CD4+ T cells and their circulating functional subsets in acute HIV-1 infection

et al. 2015

Cell Mol Immunol

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Preferential infection and depletion of gut-homing a4b7 CD4 1 T cells in the blood are observed in chronic HIV/SIV infection. The dynamic change in gut-homing a4b7 CD4 1 T cells and their functional subsets during the acute stages of HIV-1 infection are less documented. Therefore, we conducted a cohort study to investigate whether acute HIV-1 infection induced abnormalities in gut-homing a4b7 CD4 1 T cells and their functional subsets. We examined the frequency, absolute number, and functionality of gut-homing a4b7 CD4 1 T cells in 26 acute HIV-1-infected patients compared with 20 healthy individuals. We found that circulating gut-homing a4b7 CD4 1 T cells were preferentially depleted during acute HIV-1 infection and were positively correlated with absolute CD4 1 T-cell count in blood. Notably, Th17 and Th1 cell subsets of gut-homing CD4 1 T cells were also decreased, which resulted in an imbalance of T helper cells (Th1):regulatory T cells (Treg) and Treg:Th17 ratios. Gut-homing Th17 and Th1 cells were also positively correlated with the absolute number of total CD4 1 T cells and gut-homing CD4 1 T cells. The gut-homing Treg:Th17 ratio was inversely correlated with the CD4

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“…The absolute counts (cells/ll) of lymphocytes in erythrocyte lysed whole blood were determined by FACS Calibur flow cytometry as previously described. 7 The monoclonal antibodies including PE-CD4, PE-CD8, FITC-CD45RA, FITC-CD45RO, APC-62L, PerCP-CD38, and APC-CD25 were purchased from BD Corporation (USA).…”

Section: Facs Analysis Of T Cell Subsetsmentioning

confidence: 99%

The Immune Pathogenesis of Immune Reconstitution Inflammatory Syndrome Associated with Highly Active Antiretroviral Therapy in AIDS

Zheng

Zhou

et al. 2014

AIDS Research and Human Retroviruses

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The present study investigated the immunological pathogenesis of immune reconstitution inflammatory syndrome (IRIS) in acquired immunodeficiency syndrome (AIDS) patients undergoing highly active antiretroviral therapy (HAART). A total of 238 patients with AIDS who received initial HAART were included in this prospective cohort study. Blood samples were collected immediately, at baseline, at week 12, and at week 24 after initial HAART and at the onset of IRIS. Lymphocyte subsets, Th1 and Th2 cytokines, and interleukin (IL)-7 levels were measured by flow cytometry or ELISA. Among the 238 patients with AIDS who received HAART, 47 patients developed IRIS. The percentages of CD4 + and CD8 + naive, memory, and activated cells exhibited no significant differences between AIDS patients with and without IRIS 24 weeks after initial HAART. The percentage of CD4 + CD25 + Foxp3 + regulatory T cells was lower in IRIS patients than in non-IRIS patients before HAART, 12 weeks after HAART, 24 weeks after HAART, and at the onset of IRIS. IL-2 and interferon (IFN)-c levels were significantly higher at week 4 and at the onset of IRIS in IRIS patients than in non-IRIS patients. In contrast, IL-4 and IL-10 levels were significantly lower at week 4 and at the onset of IRIS in IRIS patients than in non-IRIS patients. Plasma IL-7 decreased gradually with the progression of HAART. The level of IL-7 was higher in IRIS patients than in non-IRIS patients at all follow-up time points. An imbalance of Th1/Th2 cytokines, a consistently low CD + CD25 + Fox3 + percentage, and a high IL-7 level may be crucial in the pathogenesis of IRIS in AIDS patients who had received HAART.

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A Randomized Case–Control Study of Dynamic Changes in Peripheral Blood Th17/Treg Cell Balance and Interleukin-17 Levels in Highly Active Antiretroviral-Treated HIV Type 1/AIDS Patients

Cited by 35 publications

References 30 publications

Neutrophils in antiretroviral therapy–controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment

Neutrophils in antiretroviral therapy–controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment

Preferential loss of gut-homing α4β7 CD4+ T cells and their circulating functional subsets in acute HIV-1 infection

The Immune Pathogenesis of Immune Reconstitution Inflammatory Syndrome Associated with Highly Active Antiretroviral Therapy in AIDS

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