A randomised placebo‐controlled trial to determine the effect of vitamin E in treatment of primary dysmenorrhoea

Ziaei, Saeideh; Faghihzadeh, Soghrat; Sohrabvand, Farnaz; Lamyian, Minoor; Emamgholy, T

doi:10.1111/j.1471-0528.2003.00279.x

Cited by 36 publications

(45 citation statements)

References 5 publications

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“…10 Ziaei et al in their another study reported a significant reduction in severity of pain (p -0.001< 0.05) when 200 units of vitamin E twice a day was given for 5 days. 11 Nayeban et al in their study reported a significant reduction in severity of pain (p -0.046< 0.05) when 400 units of vitamin E per day was given for 5 days.…”

Section: Discussionmentioning

confidence: 91%

Vitamin E in the treatment of primary dysmenorrhoea

Vilvapriya

Vinodhini

2018

Int J Reprod Contracept Obstet Gynecol

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Background: The objective of this study is to determine the efficacy of Vitamin E in the treatment of primary dysmenorrhoea compared to the placebo.Methods: Sixty women, aged 17-25 years old who suffered from primary dysmenorrhoea, among 1000 Women attending the gynec OPD in Kilpauk Medical College. 30 women were given 200 units of vitamin E (each tablet twice daily) and 30 were given a placebo tablets (each tablet twice daily). The treatment began two days before the beginning of menstruation and continued through the first three days of bleeding. The severity of pain and duration of pain before and after the treatment was studied. Treatment in both groups was carried out in three consecutive menstrual periods.Results: As to the findings, the mean age of the participants was 22.6 years. There was a significant difference between the pre- and post-treatment periods in terms of pain severity (P=0.72 and P=0.002, respectively) and pain duration (P=0.514 and P=0.027, respectively) in Vitamin E group. There was a significant difference observed between the Vitamin E group and placebo group regarding the mean of pain severity and duration (P=0.002 and p=0.027 respectively).Conclusions: Vitamin E helps to relieve pain in primary dysmenorrhoea. As this is a relatively easier method for control of pain with lesser amount of side effects and as it is cost effective, it can be considered as a universal drug in the treatment of primary dysmenorrhoea.

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Section: Discussionmentioning

confidence: 91%

Vitamin E in the treatment of primary dysmenorrhoea

Vilvapriya

Vinodhini

2018

Int J Reprod Contracept Obstet Gynecol

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“…Wheat germ is also rich in vitamin E, an antioxidant that can mitigate the symptoms of dysmenorrhea by preventing arachidonic acid oxidation and the production of prostaglandins (36). Twice-daily supplementation with 200 units of vitamin E has been reported to reduce the duration and severity of primary dysmenorrhea (43).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, vitamin E intake reduces the intensity of dysmenorrhea (35, 36). In other studies, positive effects of vitamin B 1 in dysmenorrhea have been addressed (37).…”

Section: Introductionmentioning

confidence: 99%

Effects of Wheat Germ Extract on the Severity and Systemic Symptoms of Primary Dysmenorrhea: A Randomized Controlled Clinical Trial

Atallahi¹,

Akbari²,

Mojab³

et al. 2014

Iran Red Crescent Med J

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Background:Primary dysmenorrhea is one of the most common disorders in women and the main cause of absenteeism from work and school.Objectives:Considering the anti-inflammatory properties of wheat germ, the present study examined the effects of wheat germ extract on the severity and systemic symptoms of primary dysmenorrhea.Patients and Methods:This triple-blinded clinical trial was performed on 80 employed women in hospitals affiliated with Hamadan University of Medical Sciences (Hamadan, IR Iran). Subjects were allocated to two groups of 45 patients. Three 400-mg capsules of wheat germ extract or placebo were used daily٫ between the 16th day of the menstrual cycle to the fifth day of the next menstrual cycle for two consecutive months. Pain intensity was measured by a visual analogue scale thrice a day and a four-point verbal rating scale was employed to assess systemic symptoms.Results:Pain severity decreased only in the wheat germ extract group (P < 0.001) and there was no statistically significant change in the placebo group. In the wheat germ extract group, the pain severity decreased from 4.701 at baseline to 1.120 at the second cycle. The reduction in total scores of systemic symptoms of dysmenorrhea was statistically significant only in the wheat germ extract group (P < 0.001) and there was not a statistically significant change in the placebo group. It revealed statistically significant differences in systemic symptoms associated with dysmenorrhea including fatigue, headache, and mood swings in experimental group.Conclusions:Wheat germ extract seems to be an effective treatment for dysmenorrhea and its systemic symptoms, probably because of its anti-inflammatory effects.

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“…Yapılan iki randomize ça-lışmada, E vitamininin dismenorede ağrı ve kanama miktarını azalttığı gösterilmiştir (40,41). Cochrane sistematik derlemesinde B1 ve B6 vitaminlerinin ve balık yağının (omega-3 yağ asitleri) plasebodan daha etkili olduğu bildirilmiştir (42).…”

Section: Diyet Ve Vitaminunclassified

Primer Dismenorede Tedavi Yaklaşımları

Akduman¹,

Budur²

2016

Anadolu Kliniği Tıp Bilimleri Dergisi

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ÖzetKadınlarda dismenore sık karşılaşılan, hastanın yaşam kalitesini azaltan, önemli bir sağlık sorunudur. Dismenorenin sağlık sistemi üzerine ekonomik yükü de oldukça fazladır. Dismenore, şiddetine bağlı olarak iş, okul ve diğer günlük aktivitelerden alıkoyabilmektedir. Primer dismenore, herhangi bir pelvik patoloji olmadan, menstrüasyon sırasında alt abdominal bölgede görülen, tekrarlayan, kramp tarzında ağrıdır. Sekonder dismenore ise pelvik patoloji varlığında görülen menstrüasyon ağrısıdır. Primer dismenore reprodüktif yaş grubunda, özellikle de adölesanlarda çok sık rastlanan bir problem iken, sekonder dismenore kırklı ve ellili yaşlarda daha sık görülür. Doğru tanı için, semptomların detaylı olarak değerlendirilmesi ve kapsamlı bir fizik muayene çok önemlidir. Hastalığın tedavi seçenekleri için konservatif yaklaşımlardan medikal tedaviye kadar, geniş bir yelpaze söz konusudur. Bu derlemede primer dismenoreyi güncel bilgiler eşliğinde ele almak ve tedavi yaklaşımları konusunda bilgi vermek amaçlanmıştır. Anahtar Sözcükler: primer dismenore; adölesan; tedavi; kadın Abstract Dysmenorrhea is an important health care problem. It is common in women and reduces the quality of life. Economic burden of dysmenorrhea on the health system is quite high. Depending on the severity of symptoms, it may restrict work performance and school and other daily activities. Primary dysmenorrhea refers to the presence of recurrent, crampy, lower abdominal pain occurring during menses in the absence of any demonstrable pathology. Secondary dysmenorrhea refers to painful menstruation in the presence of a pelvic pathology. Primary dysmenorrhea is a common problem experienced by women in their reproductive years. Secondary dysmenorrhea is more common among the women in the fourth and fifth decades of life. For correct diagnosis, a detailed evaluation of the symptoms and a comprehensive physical examination is very important. Treatment options vary from conservative approaches to medical treatments. In this review, we intended to provide contemporary information on the definition and evaluation of primary dysmenorrhea, and treatment options.

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A randomised placebo‐controlled trial to determine the effect of vitamin E in treatment of primary dysmenorrhoea

Cited by 36 publications

References 5 publications

Vitamin E in the treatment of primary dysmenorrhoea

Vitamin E in the treatment of primary dysmenorrhoea

Effects of Wheat Germ Extract on the Severity and Systemic Symptoms of Primary Dysmenorrhea: A Randomized Controlled Clinical Trial

Primer Dismenorede Tedavi Yaklaşımları

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