A randomised controlled trial of individualised, progressed early exercise in patients hospitalised with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD)

Exercise training for adults hospitalized with an acute respiratory condition: a systematic scoping review

“…Of the studies included in this review, 19 (95%) were published in peer-reviewed journals [2][3][4]12,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] and 1 (5%) was a published abstract for which further information was obtained from the author 34 (see Supplemental Table S1). These 20 studies described 16 unique randomized controlled trials, [2][3][4]12,[19][20][21][22][23][24][25][26][29][30][31]34 and 2 were single-group studies. 28,33 Two studies were qualitative analyses which utilized responses from participants recruited to two of the randomized controlled trials.…”

“…The mean age of the participants who were prescribed exercise training ranged from 51 to 76 years, and 600 (52%) participants were male. Studies were conducted in adults hospitalized with an exacerbation of chronic obstructive pulmonary disease (N = 1100 participants) 12,[19][20][21][22][23][24][25][26][28][29][30][31][32]34 or with community-acquired pneumonia (N = 918 participants). [2][3][4]33 Across the 16 randomized controlled trials and 2 single-group studies, participants allocated to the Table 1.…”

“…Quality of reporting using the Consensus on Exercise Reporting Template (higher scores indicating detailed reporting, maximum score = 16) 16 and the Template for Intervention Description and Replication (higher scores indicating detailed reporting, maximum score = 12) 17 3 Risk of bias using the Cochrane Risk of Bias Assessment 18 4 Variables related to exercise programmes in terms of content, tolerability, evaluation and adverse events intervention groups completed ~7420 training sessions over a period of 4-14 days. [2][3][4]12,[19][20][21][22][23][24][25][26][28][29][30][31]33,34 The content of the training programmes is summarized in Figure 2 and Supplemental Table S2. Approaches to exercise training included exclusive aerobic training, 24,26,31 exclusive resistance training, 20,25,29,30 a combination of aerobic and resistance training, 3,12,19,23,34 neuromuscular electrical stimulation, 21,28 whole-body vibration 22 and movement out of bed within 24 hours of hospitalization with progressive daily movement.…”

“…[2][3][4]12,[19][20][21][22][23][24][25][26][28][29][30][31]33,34 The content of the training programmes is summarized in Figure 2 and Supplemental Table S2. Approaches to exercise training included exclusive aerobic training, 24,26,31 exclusive resistance training, 20,25,29,30 a combination of aerobic and resistance training, 3,12,19,23,34 neuromuscular electrical stimulation, 21,28 whole-body vibration 22 and movement out of bed within 24 hours of hospitalization with progressive daily movement. [2][3][4]33 Eight studies individualized the prescription of the initial exercise training session using objective measures of exercise capacity, 3,12,19,23,34 peripheral muscle force, 12,19,20,…”

“…Approaches to exercise training included exclusive aerobic training, 24,26,31 exclusive resistance training, 20,25,29,30 a combination of aerobic and resistance training, 3,12,19,23,34 neuromuscular electrical stimulation, 21,28 whole-body vibration 22 and movement out of bed within 24 hours of hospitalization with progressive daily movement. [2][3][4]33 Eight studies individualized the prescription of the initial exercise training session using objective measures of exercise capacity, 3,12,19,23,34 peripheral muscle force, 12,19,20,23,25,31 and tasks commonly undertaken during activities of daily living. 34 Regarding prescription, walking-based exercise was prescribed at intensities that ranged from 40% average speed achieved during a 3-minute walk test 23 to a speed equivalent to 85% of peak oxygen consumption estimated from the distance walked on the incremental shuttle walk test.…”