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Chirality Transfer in Gold(I)‐Catalysed Direct Allylic Etherifications of Unactivated Alcohols: Experimental and Computational Study

“…α-Chiral ethers are present in many natural products, biologically active molecules and synthetic intermediates. 1 Therefore, much effort has been directed towards efficient routes to enantiomerically enriched chiral ethers through allylic etherification reactions. 2 Within this context, there is currently ongoing interest in utilising unactivated allylic alcohol electrophiles in transition-metal-catalysed allylations of various nucleophiles, 3 as the use of unactivated allylic alcohol electrophiles reduces the number of synthetic steps required (by virtue of not requiring prior derivatisation) and minimises byproduct formation.…”

Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand

“…N -Arylamides are valuable compounds widely employed in the fields of organic synthesis, pharmaceutical chemistry, or biology [ 1 , 2 , 3 ]. One of the most common synthetic protocols for their preparation is the copper-catalyzed Ullmann reaction [ 4 ] and the related Goldberg reaction (copper-catalyzed N -arylation of amides) [ 5 ].…”

Three New Cytochalasins Produced by an Endophytic Fungus in the Genus Rhinocladiella

“…Cytochalasins are a known class of mold metabolites first discovered in 1966 . There are now more than 20 known cytochalasins, isolated from a variety of fungal species, including Helminthosporium sp., Phoma sp., Xylaria sp., Hypoxylon sp., and Chalara sp. , Structurally, cytochalasins are composed of a highly substituted isoindolone ring with a benzyl group at the C-3 position and fused to an 11- to 14-membered macrocyclic ring.…”