A Questionnaire Survey of Physicians' Perspectives Regarding the Assessment of Chemotherapy-induced Peripheral Neuropathy in Patients with Breast Cancer

Abstract

The PNQ appears to be a useful instrument for the diagnosis and grading of CIPN, as well as for clinical decision-making regarding treatment modifications secondary to CIPN.

The Influence of Chemotherapy-Induced Neurotoxicity on Psychological Distress and Sleep Sisturbance in Cancer Patients

“…Moreover, the pnq is designed to clearly delineate between no interference and interference with defined activities of daily living. Hence, it is a useful instrument, with high acceptance by physicians 37 . Several researchers have reported that pnq sensory and motor scores are correlated with the fact and the fact-Gynecologic Oncology Group-Neurotoxicity questionnaires (r = 0.66 and 0.51 respectively) 38 .…”

“…First, it relied on self-reported data and did not include objective measures of nerve function such as neurologic exams or nerve conduction studies. However, numerous studies have demonstrated the reliability and validity of self-reporting tools for evaluating the severity of neuropathic symptoms in patients receiving chemotherapy 37,38,55,56 , and selfreported neuropathy has been included as an outcome measure in numerous studies 3,37,38 . A second limitation of the study is the cross-sectional nature of the data.…”

“…The pnq total score ranges from 2 to 10, with a high total score indicating severe cipn symptoms. A pnq total score of 2 was defined as grade A; 3-4, as grade B; 5-6, as grade C; 7-8, as grade D; and 9-10, as grade E 37 . The validity of the pnq has been confirmed in many studies 37,38 .…”

Assessment of Cancer-Related Neuropathy and Neuropathic Pain

“…The compliance in reporting by patients and physicians in the study was exceptional, exceeding 90% throughout the study. Additionally, when asked about the diagnostic and clinical utility of the PNQ, 84% of the physicians reported that the PNQ was helpful in the diagnosis and assessment of patients at risk for CIPN [18].…”

Adaptação transcultural e validação do instrumento <i>Chemotherapy-Induced Peripheral Neuropathy Assessment Tool</i> (CIPNAT) para o Brasil

“…O questionário apresentou uma boa aceitação e benefícios para extrair informações sobre NPIQ de acordo com a visão médica. O PNQ destaca a importância em avaliar a presença e efeito da NPIQ nas AVDs pelos pacientes e profissionais de saúde, e as percepções dos profissionais de saúde pelo questionário ressaltaram a utilidade para coletar informações, diagnosticar e graduar a NPIQ, além de auxiliar na tomada de decisões em relação a modificações no tratamento (KUROI et al, 2008). Outros estudos divergem sobre o questionário, uma vez que, os participantes relataram dificuldades na compreensão do questionário PNQ, ao confundirem os itens referentes aos sintomas relacionados à quimioterapia com os relacionados aos procedimentos cirúrgicos (SIMÃO et al, 2012).…”