“…In other words, based on emerging empirical work in this area [55], gender differences may exist within mesocorticolimbic reward and emotion regulation pathways (VTA, insula/ACC, striatum/NAcc, limbic systems), although the scope, size, and direction of these relationships has yet to be established. These developmental gender differences would be in line with the broader behavioral sexual decision-making literature, which suggests that adolescent girls are more likely than boys to have sex to bolster or advance emotional aspects of relationship development (to foster intimacy, love, and trust) [3]. While empirical studies in this area are needed, we posit that there may be neurocognitive and behavioral differences in adolescent male sexual decision-making across the dimension of reward, particularly in the early years of sexual activity.…”