Sexual risk-taking and subcortical brain volume in adolescence

Ewing, Sarah W. Feldstein; Hudson, Karen A.; Caouette, Justin; Mayer, Andrew R.; Thayer, Rachel E.; Ryman, Sephira G.; Bryan, Angela D.

doi:10.1093/abm/kax027

Cited by 10 publications

(7 citation statements)

References 80 publications

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“…The current findings support sex differences in how substance use may interact with brain structure, which is well documented in the literature due to possible interactions with sex hormones during pubertal maturation (Feldstein Ewing et al, 2018;Gennatas et al, 2017). Preclinical research has shown that females may be particularly vulnerable to changes in neuronal structure and cognitive function with nicotine exposure during development (Cross, Linker, & Leslie, 2017), and adolescent neuroimaging studies have fairly consistently reported that females show greater negative associations between brain structure and alcohol use (Feldstein Ewing, Sakhardande, & Blakemore, 2014).…”

Section: Discussionsupporting

confidence: 83%

Recent tobacco use has widespread associations with adolescent white matter microstructure

Thayer

Hansen

Prashad

et al. 2020

Addictive Behaviors

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Importance-Given the prevalence of alcohol, cannabis, and tobacco use during adolescence, it is important to explore the relative relationship of these three substances with brain structure.Objective-To determine associations between recent alcohol, cannabis, and tobacco use and white and gray matter in a large sample of adolescents.Design, Setting, and Participants-MRI data were collected in N=200 adolescents ages 14-18 (M=15.82 years; 67% male; 61% Hispanic/Latino). On average, during the past month, participants reported consuming 2.05 drinks per 1.01 drinking day, 0.64 grams per 6.98 cannabis use days, and 2.49 cigarettes per 12.32 smoking days.Main Outcomes and Measures-General linear models were utilized to examine past 30-day average quantities of alcohol, cannabis, and tobacco use, age, sex, and sex by substance interactions in skeletonized white matter (fractional anisotropy and axial, radial, and mean diffusivity) and voxel-based morphometry of gray matter (volume/density).Results-Tobacco use was negatively associated with white matter integrity (radial and mean diffusivity) with peak effects in inferior and superior longitudinal fasciculi. Cannabis use was negatively associated with white matter integrity (axial diffusivity) in a small cluster in the left superior longitudinal fasciculus. No associations were observed between recent alcohol use and white or gray matter overall, but interactions showed significant negative associations between alcohol use and white matter in females.

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Section: Discussionsupporting

confidence: 83%

Recent tobacco use has widespread associations with adolescent white matter microstructure

Thayer

Hansen

Prashad

et al. 2020

Addictive Behaviors

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“…Even fewer studies have examined the role of puberty and brain development in adolescent health risking behaviors. Pubertal stage has been found to moderate the association between limbic brain structure and risky sexual behaviors (Feldstein Ewing et al, 2018), and greater testosterone levels has been associated with increased alcohol use in males via amygdala-OFC resting state connectivity (Peters et al, 2015). Interestingly, there has been no research to date on how puberty and brain development may together predict positive outcomes such as prosociality, normative sexual development and health promoting behaviors (see Suleiman et al, 2017).…”

Section: Overviewmentioning

confidence: 99%

Puberty and the human brain: Insights into adolescent development

Vijayakumar

Macks

Shirtcliff

et al. 2018

Neuroscience & Biobehavioral Reviews

283

229

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Alongside the exponential flourish of research on age-related trajectories of human brain development during childhood and adolescence in the past two decades, there has been an increase in the body of work examining the association between pubertal development and brain maturation. This review systematically examines empirical research on puberty-related structural and functional brain development in humans, with the aim of identifying convergent patterns of associations. We emphasize longitudinal studies, and discuss pervasive but oft-overlooked methodological issues that may be contributing to inconsistent findings and hindering progress (e.g., conflating distinct pubertal indices and different measurement instruments). We also briefly evaluate support for prominent models of adolescent neurodevelopment that hypothesize puberty-related changes in brain regions involved in affective and motivational processes. For the field to progress, replication studies are needed to help resolve current inconsistencies and gain a clearer understanding of pubertal associations with brain development in humans, knowledge that is crucial to make sense of the changes in psychosocial functioning, risk behavior, and mental health during adolescence.

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“…High socioeconomic status (SES) (Oshri et al, 2019) protects children against antisocial behaviors (Palma-Coca et al, 2011), school problems (Sirin, 2005), learning disorders (Fluss et al, 2009), attention deficit and hyperactivity disorder (Assari & Caldwell, 2019a;Collins & Cleary, 2016;Jablonska et al, 2020;Machlin, McLaughlin, & Sheridan, 2019), aggression (Heshmat et al, 2016), early sexual initiation (Feldstein Ewing et al, 2018), and use of tobacco (Barreto, de Figueiredo, & Giatti, 2013;Kaleta, Usidame, Dziankowska-Zaborszczyk, & Makowiec-Dabrowska, 2015), alcohol (Moore & Littlecott, 2015;Silveira et al, 2014), and drugs (Gerra et al, 2020). The effects are partially attributed to the effects of SES on brain development (Javanbakht et al, 2015;Masten, Telzer, & Eisenberger, 2011;Wu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Race, Ethnicity, Family Socioeconomic Status, and Children’s Hippocampus Volume

Assari¹

2020

RHS

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Introduction: The hippocampus has a significant role in memory, learning, and cognition. Although hippocampal size is highly susceptible to family socioeconomic status (SES) and associated stress, very little is known on racial and ethnic group differences in the effects of SES indicators on hippocampus volume among American children. Purpose: This study explored the multiplicative effects of race, ethnicity, and family SES on hippocampus volume among American children. Methods: Using data from the Adolescent Brain Cognitive Development (ABCD), we analyzed the functional Magnetic Resonance Imaging (fMRI) data of 9390 9-10 years old children. The main outcome was hippocampus volume. The predictor was parental education. Subjective family SES was the independent variable. Age, sex, and marital status were the covariates. Racial and ethnic group membership were the moderators. To analyze the data, we used regression models. Results: High subjective family SES was associated with larger hippocampus volume. This effect was significantly larger for Whites than Black families. Conclusions: The effect of subjective family SES on children’s hippocampus volume is weaker in Black than White families.

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Sexual risk-taking and subcortical brain volume in adolescence

Abstract: These data highlight the potential relevance of subcortical socioemotional processing structures in adolescents' sexual decision-making.

Cited by 10 publications

References 80 publications

Recent tobacco use has widespread associations with adolescent white matter microstructure

Recent tobacco use has widespread associations with adolescent white matter microstructure

Puberty and the human brain: Insights into adolescent development

Race, Ethnicity, Family Socioeconomic Status, and Children’s Hippocampus Volume

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