A quantitative study of daytime sleepiness induced by carbamazepine and add-on vigabatrin in epileptic patients

Bonanni, Enrica; Massetani, R.; Galli, Renato; Gneri, C.; Petri, M.E. Yoldi; Iudice, Alfonso; Murri, Luigi

doi:10.1111/j.1600-0404.1997.tb00097.x

Cited by 27 publications

(11 citation statements)

References 21 publications

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“…Only one class III study in patients with focal epilepsy was identified in which the patients on chronic carbamazepine therapy were enrolled . Patients with poorly controlled seizures received vigabatrin as an adjunctive therapy.…”

Section: Resultsmentioning

confidence: 99%

Effects of epilepsy treatments on sleep architecture and daytime sleepiness: An evidence‐based review of objective sleep metrics

2013

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SUMMARYObjective: Sleep is considered restorative, and good quantity and quality sleep is required for memory consolidation and synaptic plasticity. Sleep disorders are common in patients with epilepsy. Poor sleep quality or quantity may worsen seizure control. On the other end, seizures and epilepsy may worsen the sleep quality and set a vicious cycle. In addition, antiepileptic drugs have an effect on sleep architecture. We performed a systemic literature review with a goal to evaluate the effect of antiepileptic drugs and nondrug treatments for epilepsy on sleep architecture to help better understand treatment effects, especially in patients with epilepsy and sleep problems. Methods: We searched PubMed and identified studies that evaluated objective sleep outcomes for an antiepileptic drug. We also searched for studies with objective sleep outcomes that evaluated other epilepsy treatments such as epilepsy surgery, vagus nerve stimulation, and ketogenic diet. Results: The studies were categorized based on evidence class and study population for an individual antiepileptic drug or treatment. We identified that most antiepileptic drugs and nondrug treatments for epilepsy affect sleep architecture. Significance: We identified that gabapentin, tiagabine, pregabalin, clobazam, and carbamazepine reduce sleep latency and/or improve sleep efficiency. Phenobarbital, valproic acid, and higher-dose levetiracetam aggravate daytime sleepiness, whereas topiramate and zonisamide do not. Vagus nerve stimulation reduces daytime sleepiness, and ketogenic diet improves slow-wave sleep. Epilepsy surgery may improve nocturnal sleep only in a subgroup of patients with improved seizure frequency. Further studies are needed to evaluate the dose-dependent sleep effects of antiepileptic drugs and nondrug treatments independent of the improvement of epilepsy, and to identify if these changes are clinically significant.

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Section: Resultsmentioning

confidence: 99%

Effects of epilepsy treatments on sleep architecture and daytime sleepiness: An evidence‐based review of objective sleep metrics

2013

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“…Many drugs exert a stabilizing effect on sleep improving sleep quality, others aggravate sleep parameters, while dose-dependent effects have not been extensively evaluated, yet. 30,31 On the other hand, sleep alterations can influence epileptic activity, as sleep stages represent forms of varied neuronal synchronization. Non-REM (NREM) sleep is known to facilitate seizures onset and spread, while REM stage suppresses epileptic activity, as it consists a state of cortical desynchronization.…”

Section: Discussionmentioning

confidence: 99%

Sleep Disturbances in Children with Rolandic Epilepsy

et al. 2016

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The aim of this study is to investigate through polysomnography sleep quality in children with rolandic epilepsy and compare sleep variables between these children and healthy controls. Our study population included 15 children with rolandic epilepsy and 27 healthy children who underwent overnight polysomnography. Parameters about sleep architecture and sleep respiratory events were recorded and analyzed. The level of statistical significance was set at 0.05. Patients and controls did not differ in basic epidemiological traits. The percentage of sleep stage rapid eye movement was significantly lower in the epilepsy group. Moreover, the mean value of the obstructive apnea index and the obstructive apnea-hypopnea index was significantly higher in children with rolandic epilepsy compared with healthy children. Longest apnea duration and basal Spo during sleep had also the trend to be higher and lower, respectively, in children with epilepsy. Children with rolandic epilepsy exhibit alterations in sleep architecture, as well as in sleep respiratory patterns. Therefore, sleep quality should be routinely considered in the long-term follow-up of these children.

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“…However, conflicting studies reported that CBZ did not influence the sleep of patients with epilepsy or disturbed it by increasing wake/sleep fragmentation, thus diminishing both SWS and REM sleep. Some researchers thought that these are merely initial effects that can be reversed by chronic treatment [ 135 , 136 , 140 , 141 ]. A similar agent is phenytoin (PHT), an AED that falls into the same group as CBZ.…”

Section: Sleep and Anticonvulsant Therapymentioning

confidence: 99%

The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy

Wang

Zhang

et al. 2017

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Background:Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our under-standing of this relationship remains unclear.Results:The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non rapid eye movement sleep and idiopathic generalized epilepsy share the same thalamocortical networks. Most of neurotransmitters and neuromodulators such as adenosine, melatonin, prostaglandin D2, serotonin, and histamine are found to regulate the sleep-wake behavior and also considered to have antiepilepsy effects; antiepileptic drugs, in turn, also have effects on sleep. Fur-thermore, many drugs that regulate the sleep-wake cycle can also serve as potential antiseizure agents. The nonpharmacologi-cal management of epilepsy including ketogenic diet, epilepsy surgery, neurostimulation can also influence sleep.Conclusion:In this paper, we address the issues involved in these phenomena and also discuss the various therapies used to modify them.

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A quantitative study of daytime sleepiness induced by carbamazepine and add-on vigabatrin in epileptic patients

Abstract: Some sleepiness occurs in chronically CBZ-treated epileptic patients, which can be objectively measured by the MSLT, but it is not aggravated by add-on VGB.

Cited by 27 publications

References 21 publications

Effects of epilepsy treatments on sleep architecture and daytime sleepiness: An evidence‐based review of objective sleep metrics

Effects of epilepsy treatments on sleep architecture and daytime sleepiness: An evidence‐based review of objective sleep metrics

Sleep Disturbances in Children with Rolandic Epilepsy

The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy

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