A Quantitative in Vitro Model for Silicone Oil Emulsification

Bartov, Elisha; Pennarola, Fausto; Savion, Naftali; Naveh, Nava; Treister, Giora

doi:10.1097/00006982-199212031-00006

Cited by 44 publications

(35 citation statements)

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“…These substances may reduce the interfacial tension and greatly facilitate the emulsification. [51][52][53][54] A recent study by Dresp and Menz 55 demonstrated a great variety of contaminants in emulsified samples of explanted silicone oil, when compared with nonemulsified samples. This was found in both 1000 and 5000 cs samples.…”

Section: Eyementioning

confidence: 99%

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Tognetto

Lepori

Lapasin

et al. 2008

Eye

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Aim To study the solubility of perfluorohexyloctane (F6H8) in silicone oil (polydimethylsiloxane (PDMS) 1000) and to measure the viscosity and the specific gravity of the mixture obtained (heavy silicone oil or HSO tamponade) to define the ideal ratio of these components. Methods The solubility diagram of the mixture was obtained with the turbidimetric method, indicating the miscibility of F6H8 and silicone oil 1000 at all the useful temperatures. The viscosity was measured in steady shear conditions by using a controlled stress rheometer (Haake RS150) and a double cone/plate (DC 60/4) system, both at 25 and 371C for different volume per cent compositions of the mixture. The specific gravity was measured at 371C using a digital densimeter. Results A mixture of F6H8 30 v% and PDMS 70 v% was found to be transparent and stable at all the useful temperatures. By combining these proportions of the two substances, a resultant density of 1.06 g/cm 3 was obtained. The viscosity of the 30% F6H8 mixture was 203 mPa.s at 251C and 163 mPa.s at 371C respectively. Conclusions The ideal F6H8 and silicone oil mixture can be obtained combining 30% of F6H8 with 70% of silicone oil 1000. This mixture seems to have rheological properties useful for its use as an alternative intraocular heavy tamponade.

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Section: Eyementioning

confidence: 99%

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Tognetto

Lepori

Lapasin

et al. 2008

Eye

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“…It has previously been shown that certain serum components reduce the surface tension at the interface between the aqueous humor and the IOL, for example, the absorption of denatured proteins [13][14][15]. In particular, phospholipids in the aqueous humor, present in high proportions especially in the event of disturbed bloodaqueous barrier function, act as detergents and further reduce the IOL-aqueous interface surface tension [13,14].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, phospholipids in the aqueous humor, present in high proportions especially in the event of disturbed bloodaqueous barrier function, act as detergents and further reduce the IOL-aqueous interface surface tension [13,14]. This means that substances containing lipids reach the interior of the IOL where, under normal physiological circumstances, they would not penetrate.…”

Section: Discussionmentioning

confidence: 99%

Vacuoles in the Acrysof<sup>TM</sup> Intraocular Lens as Factor of the Presence of Serum in Aqueous Humor

et al. 2001

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Objective: Acrysof™ (Alcon) foldable lenses (IOLs) have been shown to be highly biocompatible and exhibit a low incidence of posterior capsular opacification. However, minute vacuoles or ‘glistenings’ have been observed in some Acrysof IOLs. The clinical relevance of vacuole formation is presently unclear. To help clarify the influence of factors present under in vivo conditions on vacuole formation, the present experimental study examines the influence of aqueous humor components on the occurrence of vacuoles in Acrysof IOLs. Methods: A total of 12 sterile Acrysof IOLs (Alcon, MA60BM) were incubated at body temperature (37°C) for 3 or 6 months in anterior-chamber aqueous humor with or without human serum. The center portion was cut from two unconditioned, unhydrated, sterile control IOLs and the 12 conditioned IOLs and examined using light microscopy for vacuole formation. A third unconditioned, hydrated control IOL was examined using light and scanning electron microscopy. Measures: The incidence of vacuoles was quantified by two independent investigators using light microscopy. After hydration with balanced salt solution, the surface quality of a control IOL was examined using scanning electron microscopy. Results: The control IOLs exhibited no or very few vacuoles. Scanning electron microscopy revealed that the control IOLs had normal surface texture without any surface vacuoles. IOLs that had been conditioned in aqueous humor without serum exhibited no great increase in the number of vacuoles, whereas IOLs conditioned in aqueous humor with serum exhibited a greater number of vacuoles that increased over time. Conclusions: The number of vacuoles increases with incubation time in aqueous humor containing serum. The addition of serum increased the proportion of lipids and proteins in the solution, which also occurs with a breakdown in the blood-aqueous barrier. The results of the present study point to a physiological factor that may lead to vacuole formation in IOLs and may aid clinicians in identifying risk factors involved in the formation of vacuoles.

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“…4,5 Several factors may contribute to SiO emulsification, including the use of low viscosity SiOs, reduced surface tension, residual fluid or hemorrhage in the vitreous cavity. 3,[5][6][7] Also, many complications associated with the emulsification of SiO. 1,8 Elevation of intraocular pressure (IOP) is a significant, common, and chronic complication of intraocular SiO.…”

Section: Introductionmentioning

confidence: 99%