A Quantitative Evaluation of the Relationships Between Growth Hormone Secretion and Delta Wave Electroencephalographic Activity During Normal Sleep and After Enrichment in Delta Waves

Gronfier, Claude; Luthringer, R.; Follénius, M.; Schaltenbrand, Nicolas; Mâcher, Jean-Paul; Muzet, Alain; Brandenberger, G.

doi:10.1093/sleep/19.10.817

Cited by 125 publications

(55 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We failed to find a significant association between slow-wave sleep and GH levels, which confirmed a previous report (van Cauter et al, 2000) but has been discussed controversially. Studies using more elaborate techniques to assess the GH secretion, that is, 30 s blood sampling or deconvolution procedure for statistical analyses, strongly support a close relationship between delta EEG activity and GH secretion (Holl et al, 1991;Gronifier et al, 1996). Although we established 10-min blood sampling and peak detection analysis, our results may still be confounded by methodological limitations.…”

Section: Discussionmentioning

confidence: 83%

Acute Cortisol Administration Promotes Sleep Intensity in Man

Frieß

Tagaya

Grethe

et al. 2003

Neuropsychopharmacol

View full text Add to dashboard Cite

The neuronal mechanisms of sleep generation, in particular synchronization of brain activity in the process of non-rapid-eye movement (non-REM) sleep, has been elucidated in the past decade. A previous study of our group showed that acute administration of cortisol is known to increase slow-wave sleep and suppress rapid-eye movement (REM) sleep in man. To further elucidate the non-REM sleeppromoting effects of cortisol with respect to the synchronization of cortical activity, it is important to establish a sleep-state-specific quantitative EEG analysis. We therefore investigated the effects of repetitive injections of hydrocortisone on spectral composition of sleep EEG in 10 healthy male young volunteers. In addition, we performed high-frequency blood samplings to assess the relation between changes in the sleep EEG and sleep-associated secretion of growth hormone (GH). Cortisol administration resulted in a significant increase in highly synchronized EEG activity including delta and theta frequencies, according to a higher amount of slow-wave sleep. This effect predominated in the first few hours of night sleep. REM sleep was decreased, which appeared to be secondary to the lengthened first sleep cycle. The cortisol-induced stimulation of GH release did not occur in correspondence with the increased slow-wave activity. In view of the sleep impairing properties of corticotropin-releasing hormone (CRH) and the sleep-promoting function of GH-releasing hormone, it appears likely that a negative feedback inhibition of endogenous CRH was the key mechanism mediating the observed results. The cortisol-induced effects on sleep intensity and sleep-associated GH secretion appeared to be driven by different mechanisms.

show abstract

Section: Discussionmentioning

confidence: 83%

Acute Cortisol Administration Promotes Sleep Intensity in Man

Frieß

Tagaya

Grethe

et al. 2003

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…33 GH is released in a pulsatile fashion, with the initial secretion probably synchronized with the onset of slow-wave sleep (SWS), with a strong correlation with ␦-wave activity, 34 within 90 to 120 minutes from the onset of sleep. 29 In adults, there is convincing evidence of a consistent relationship be- tween SWS and increased GH secretion and decreased GH secretion with awakenings.…”

Section: Discussionmentioning

confidence: 99%

Growth and Biochemical Markers of Growth in Children With Snoring and Obstructive Sleep Apnea

et al. 2002

View full text Add to dashboard Cite

ABSTRACT. Objective. The pathophysiological mechanisms of growth impairment frequently associated with the obstructive sleep apnea syndrome (OSAS) in children are poorly defined. The main objective of this study was to evaluate whether nighttime upper airway obstruction attributable to adenotonsillar hypertrophy and subsequent surgical treatment affect the circulating concentrations of insulin-like growth factor-I (IGF-I) and IGFbinding protein 3 (IGFBP-3) along with other growth parameters in children.Patients and Methods. We initially studied 70 children (mean age: 5.8 years; range: 2.4 -10.5 years) admitted to a university hospital because of clinical symptoms of OSAS. Their sleep was monitored with a 6-channel computerized polygraph. Data on anthropometry and circulating concentrations of IGF-I and IGFBP-3 were generated and compared with corresponding characteristics in control children (N ‫؍‬ 35). Thirty children with an obstructive apnea-hypopnea index (OAHI) of 1 or more were categorized as children with OSAS (mean OAHI: 5.4 [95% confidence interval for mean (CI): 3.8 -6.9]), whereas 40 children with an OAHI of <1 were considered as primary snorers (PS) (mean OAHI 0.13 [95% CI: 0.05-0.21]). Nineteen children with OAHI >2 underwent adenotonsillectomy attributable to OSAS and were reassessed 6 months later together with 34 nonoperated children with OAHI <2.Results. There were no initial differences in relative height and weight for height between the 3 groups of children. No differences were observed in peripheral IGF-I concentrations, but both OSAS and PS children had reduced peripheral IGFBP-3 levels. The operated children with initial OSAS experienced a highly significant reduction in their OAHI from 7.1 (95% CI: 5.1-9.1) to 0.37 (95% CI: 0.2-0.95). Weight-for-height, body mass index, body fat mass, and fat-free mass increased during the follow-up in the operated children with OSAS, whereas only fat-free mass and relative height increased in the PS children. Both the IGF-I and the IGFBP-3 concentrations increased significantly in the operated children, whereas no significant changes were seen in the PS children.Conclusions. These observations indicate that growth hormone secretion is impaired in children with OSAS and PS. Respiratory improvement after adenotonsillectomy in children with OSAS results in weight gain and restored growth hormone secretion. Pediatrics 2002;109(4). URL: http://www.pediatrics.org/cgi/content/full/109/4/e55; snoring, obstructive sleep apnea, growth hormone, insulinlike growth factor-I, insulin-like growth factor-binding protein 3.ABBREVIATIONS. OSAS, obstructive sleep apnea syndrome; GH, growth hormone; IGF-I, insulin-like growth factor-I; IGFBP-3, insulin-like growth factor-binding protein 3; PS, primary snorer; EMG, electromyogram; OAHI, obstructive sleep apnea-hypopnea index; SDS, standard deviation score; BMI, body mass index; SWS, slow-wave sleep. S noring is relatively common in children, with the prevalence of regular snoring about 10% in preschool-aged subjects. 1-3 Obs...

show abstract

“…Ritanserin, a selective 5-HT 2 receptor antagonist, increases endogenous GH release and NREM sleep [13]. The strong association between sleep and GH release raises the possibility that pharmacological agents that increase NREM sleep can also stimulate GH secretion [13].…”

mentioning

confidence: 99%

Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats

Tarasiuk

Berdugo-Boura

Troib

et al. 2011

European Respiratory Journal

View full text Add to dashboard Cite

Upper airway obstruction (UAO) can lead to abnormal growth hormone (GH) homeostasis and growth retardation but the mechanisms are unclear. We explored the effect of UAO on hypothalamic GH-releasing hormone (GHRH), which has a role in both sleep and GH regulation.The tracheae of 22-day-old rats were narrowed; UAO and sham-operated animals were sacrificed 16 days post-surgery. To stimulate slow-wave sleep (SWS) and GH secretion, rats were treated with ritanserin (5-HT 2 receptor antagonist). Sleep was measured with a telemetric system. Hypothalamic GHRH, hypothalamic GHRH receptor (GHRHR) and GH receptor, and orexin were analysed using ELISA, real-time PCR and Western blot.UAO decreased hypothalamic GHRH, GHRHR and GH receptor levels, while orexin mRNA increased (p,0.01). In UAO rats, the duration of wakefulness was elevated and the duration of SWS, paradoxical sleep and slow-wave activity was reduced (p,0.001). Ritanserin alleviated these effects, i.e. normalised hypothalamic GHRH content, decreased wake duration, increased duration and depth of SWS, and attenuated growth impairment (p,0.001).Here, we present evidence that growth retardation in UAO is associated with a reduction in hypothalamic GHRH content. Our findings show that abnormalities in the GHRH/GH axis underlie both growth retardation and SWS-disorder UAO.

show abstract

A Quantitative Evaluation of the Relationships Between Growth Hormone Secretion and Delta Wave Electroencephalographic Activity During Normal Sleep and After Enrichment in Delta Waves

Cited by 125 publications

References 25 publications

Acute Cortisol Administration Promotes Sleep Intensity in Man

Acute Cortisol Administration Promotes Sleep Intensity in Man

Growth and Biochemical Markers of Growth in Children With Snoring and Obstructive Sleep Apnea

Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats

Contact Info

Product

Resources

About