A pyridine alkaloid from Ceropegia juncea

Adibatti, N.A.; Thirugnanasambantham, P.; Kulothungan, C.; Subramanian, Venkataraman; Kameswaran, L; Balakrishna, K.; Sukumar, E.

doi:10.1016/0031-9422(91)83683-c

Cited by 58 publications

(26 citation statements)

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“…Cerpegin (1,1-dimethylfuro[3,4-C]pyridine-3,4(1H,5H)-dione), the alkaloid present in root tubers of C. bulbosa (Nadkarni, 1976), was identified as pyridine, which is a rare alkaloid found in nature (Adibatti et al, 1991). Cerpegin is recognized to have analgesic properties (Sukumar et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

In vitro conservation protocol of Ceropegia bulbosa: An important medicinal and threatened plant species of Western Rajasthan

Parihar

2017

Plant Sci. Today

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Section: Introductionmentioning

confidence: 99%

In vitro conservation protocol of Ceropegia bulbosa: An important medicinal and threatened plant species of Western Rajasthan

Parihar

2017

Plant Sci. Today

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“…Cerpegin was extracted from powdered callus samples for 24 h in 90 % ethanol (v/v) by using a rotary shaker (Adibatti et al, 1991) The filtrate was condensed in vacuo to a syrupy mass and mixed with 10 ml 1 % sulphuric acid. The acidic extract was cooled and mixed with 10 ml chloroform in a separating funnel.…”

Section: Extraction Of Alkaloid Cerpegin and Chromatographic Separationmentioning

confidence: 99%

“…The fleshy stem is used as a raw material for traditional and folk medicines for the treatments of stomach and gastric disorders (Jain, 1991). The alkaloid cerpegin was isolated and identified as pyridone type alkaloid, which are relatively rare in nature (Adibatti et al, 1991). The total alkaloidal fraction exhibited promising hepatoprotective, antipyretic, analgesic, local anesthetic, anti-ulcer, mast-cell stabilizing, tranquillsing and hypotensive activities and was devoid of side effects as noted out by the sub-acute toxicity studies (Adibatti et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

“…The alkaloid cerpegin was isolated and identified as pyridone type alkaloid, which are relatively rare in nature (Adibatti et al, 1991). The total alkaloidal fraction exhibited promising hepatoprotective, antipyretic, analgesic, local anesthetic, anti-ulcer, mast-cell stabilizing, tranquillsing and hypotensive activities and was devoid of side effects as noted out by the sub-acute toxicity studies (Adibatti et al, 1991). Although C. juncea is an important source of Ayurvedic drug, but due to the lack of proper cultivation practice, low number of seed formation, destruction of plant habitats and its removal is leading to a progressive devastation of the species.…”

Section: Introductionmentioning

confidence: 99%

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Multiple shoot regeneration and alkaloid cerpegin accumulation in callus culture of Ceropegia juncea Roxb.

Nikam

Savant

2009

Physiol Mol Biol Plants

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This is the first report of in vitro propagation and alkaloid accumulation in callus cultures of Ceropegia juncea Roxb. a source of "Soma" drug in Ayurvedic medicine. Multiple shoots and callus induction was optimized by studying the influence of auxins [IAA (Indole-3-acetic acid), NAA (2-Naphthalene acetic acid) and 2,4-D (2,4-Dichlorophenoxyacetic acid.)] and cytokinins [BA (6-benzyladenine) and Kin (Kinetin)] alone and in combinations. The best response for multiple shoot induction was obtained in nodal explants on MS medium supplemented with 7.5 μM Kin (8.5 ± 3 shoots per explants). The shoots were rooted on half strength MS (Murashige and Skoog's) medium fortified with either IAA or NAA (0.5-2.0 μM). The plantlets were transferred directly to the field with 100 % success rate. Supplementation of MS medium with auxins and cytokinins enhanced the growth of callus but inhibited the shoot regeneration in nodal explants. Best callus induction and proliferation observed on MS + 1 μM 2,4-D+5 μM BA. However the maximum cerpegin content (470 μg/g dry weight) was recorded in dried callus derived on MS+10 μM IAA+5 μM BA. Quantitative TLC (Thin layer chromatography) studies of the callus revealed a phytochemical profile similar to that of naturally grown plants. The calli were maintained by subculturing at 4 weeks interval on fresh parent medium over a period of 34 months. The optimized in vitro propagation and callus culture protocol offers the possibilities of using organ/callus culture technique for vegetative propagation and production of cerpegin alkaloid.

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“…Several workers have reported that the tubers of Ceropegias are edible and contain starch, sugars, gum, albuminoids, carbohydrates, fats, and crude fi ber (Mabberly 1987 ;Jain and De Fillips 1991 ) . A pyridine-type alkaloid, namely, "cerpegin," present in the root tubers of C. santapaui exhibited promising hepatoprotective, antipyretic, antiulcer, analgesic, mast cell stabilizing, tranquilizing, and hypotensive activities (Adibatti et al 1991 ;Sukumar et al 1995 ) . C. santapaui is overexploited due to pharmacological importance of "cerpegin.…”

Section: Ceropegia Santapaui Wadhwa and Ansarimentioning

confidence: 97%

In Vitro Protocols for Ornamental Climbers

Shaheen

Shahzad

2015

Biotechnological Strategies for the Conservation of Medicinal and Ornamental Climbers

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Since the time immemorial, plants and plant parts thereof have been used as medicinal sources to cure various ailments and diseases. Recent era witnessed a great loss of this natural wealth because of its excessive use and overexploitation. Thus, it is the need of an hour to take immediate and possible measures for conserving such a great wealth. With the advent of biotechnological approaches, new vitas and horizons were broadened in every sphere of research including plant biotechnology that boosted during the present century and played a vital role in conserving ornamental plants, thus maintaining the depleting natural wealth under laboratory conditions in a short span of time. In vitro studies of several important ornamental climbers have been carried out by different workers, viz., Gloriosa superba , Ceropegia spp . , Allamanda , Passifl ora spp., etc. The present chapter deals with the detailed account of successful protocols developed through in vitro propagation of such elite germplasms.

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A pyridine alkaloid from Ceropegia juncea

Cited by 58 publications

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In vitro conservation protocol of Ceropegia bulbosa: An important medicinal and threatened plant species of Western Rajasthan

In vitro conservation protocol of Ceropegia bulbosa: An important medicinal and threatened plant species of Western Rajasthan

Multiple shoot regeneration and alkaloid cerpegin accumulation in callus culture of Ceropegia juncea Roxb.

In Vitro Protocols for Ornamental Climbers

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