A “pursuit and interception” strategy of amplified autophagy inhibition for tumor therapy based on ultra-small Rh nanoparticles

Bioorthogonal dissociative rhenium(i) photosensitisers for controlled immunogenic cell death induction

“…The protein p62 is a substrate degraded in the autolysosomes, and higher expression levels indicate inhibition of lysosomal degradation. 44 Upon combined treatments, the expression level of p62 was remarkably upregulated compared to the control groups. Collectively, the activation of complex 4 with TCO-OH followed by light irradiation can efficiently inhibit autophagosome formation and lysosomal degradation, owing to the release of the more cytotoxic complex 3a, which also acts as an efficient 1 O 2 photosensitiser.…”

Nano‐bio‐interface: Unleashing the Potential of Noble Nanometals

“…These electrochemical approaches have advanced the field of nanobiotechnology through their versatility and powerful tools for constructing nano-bio-interfaces, investigating molecular dynamics, enabling label-free biosensing, and detecting specific DNA sequences. AuNPs Antibacterial Oral administration and in vivo synthesis [172] AuNPs Antibacterial Deoxyribonuclease functionalized AuNCs and effectively remove biofilms [173] Aminobenzeneboronic acid modified AuNCs Antibacterial and self-monitor Self-monitoring residual dosage [174] PolySC 4 AP/FGGC@AuNC assemblies b) Mitochondrial imaging Host-guest assembly and high quantum yield [175] Pt(IV)-ALA-Chitosan-AuNCs c) Anticancer and bioimaging Traceable nanocluster and combinatorial therapy [176] AuNCs/QGDs/MPA/PEI d) Anticancer pH-and near-infrared-responsive and combinatorial therapy [177] AgNCs/AgNPs Antibacterial and bioimaging Versatile antimicrobial [178] DNA-templated AgNCs Anticancer and bioimaging Combinatorial therapy and fluorescence tracing and chemo drug delivery capabilities [179] Peptide-protected AgNCs Antimicrobial Green synthesis [180] PtNCs Fluorescent probe Detecting and imaging HER2 e) [181] Pillararene-functionalized RhNPs Antibacterial Photothermal sterilization and efficient catalytic ability (reduce nitrophenols and azo dyes) [182] uRh-mSNO NPs f ) Anticancer Autophagy inhibition effect and peroxidase mimic and lysosome dysfunction [183] PdNPs/covalent organic framework g) Biosensor and bioimaging Multicolor imaging [184] Hyaluronate-modified Au@PtNPs Anticancer and bioimaging Transdermal delivery and photoacoustic imaging [169] Yeast microcapsule-derived Au/PtNPs Cancer immunotherapy Combinatorial therapy and chemodynamic/photothermal synergistic treatment [185] Core-shell structured Au@Pd Anticancer ROS augmentation-induced mild PTT [186] a)…”