A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression

Wang, Qiuhong; Shu, Zunpeng; Xing, Na; Xu, Bingqing; Wang, Changfu; Sun, Guibo; Sun, Xiaobo; Kuang, Hai‐Xue

doi:10.1016/j.ijbiomac.2016.01.010

Cited by 46 publications

(17 citation statements)

References 27 publications

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“…Ephedra sinica Stapf is a traditional Chinese medicine of Ephedraceae in China (Liang et al 2018), which contains many chemicals, such as ephedrine and pseudoephedrine (Andraws et al 2005;Ma et al 2007), flavonoids (Amakura et al 2013), polysaccharides (Zhao et al 2009), phenolic compounds (Cottiglia et al 2005) and proanthocyanidins (Zang et al 2013). It shows significant activity in asthma, fever, cough, rheumatoid arthritis (Wang et al 2016), and also promotes diuresis and sweat (Ma et al 2018).…”

mentioning

confidence: 99%

Characterization of the complete chloroplast genome of Ephedra sinica Stapf (Ephedraceae), a traditional Chinese medicine

Zhang

Liang

2019

Mitochondrial DNA Part B

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mentioning

confidence: 99%

Characterization of the complete chloroplast genome of Ephedra sinica Stapf (Ephedraceae), a traditional Chinese medicine

Zhang

Liang

2019

Mitochondrial DNA Part B

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“…24,25) Therefore, Eph might suppress formalininduced pain by affecting the central nervous system in a manner similar to that of the α 2 -adrenoceptor agonist dexmedetomidine, which induces analgesic effects via stimulation of α 2 -adrenoceptors. 26) At 6 h after oral administration, EHE-Ts, EHE-To, and EFE suppressed second-phase pain; but Eph did not exert that effect. Therefore, it is possible that during the second phase of analgesia, the suppression of second-phase pain by EHE is attributable to constituents other than EAs.…”

Section: Discussionmentioning

confidence: 90%

Analgesic Effects of Ephedra Herb Extract, Ephedrine Alkaloids–Free Ephedra Herb Extract, Ephedrine, and Pseudoephedrine on Formalin-Induced Pain

Nakamori

Takahashi

Hyuga

et al. 2019

Biological & Pharmaceutical Bulletin

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The analgesic effect of Ephedra Herb (EH) is believed to be derived from the anti-inflammatory action of pseudoephedrine (Pse). We recently reported that ephedrine alkaloids-free EH extract (EFE) attenuates formalin-induced pain to the same level as that achieved by EH extract (EHE), which suggests that the analgesic effect of EH may not be due to ephedrine alkaloids (EAs). To examine the contribution of EAs to the analgesic effect of EH, mice were injected with formalin to induce a biphasic pain reaction (first phase, 0-5 min; second phase, 10-45 min) at various time points after oral administration of the following test drugs: ephedrine (Eph), Pse, "authentic" EHE from Tsumura & Co. (EHE-Ts), EFE, and EHE that was used as the source of EFE (EHE-To). Biphasic pain was suppressed at 30 min after administration of Eph, EHE-Ts, and EHE-To. At 6 h after administration of EFE, EHE-To, and Pse-and at 4 to 6 h after administration of EHE-Ts-only second-phase pain was suppressed; however, the effect of Pse at 6 h was not significant. These results suggested that EHE has a biphasic analgesic effect against biphasic formalin-induced pain: in the first phase of analgesia (30 min after administration), biphasic pain is suppressed by Eph; in the second phase of analgesia (4-6 h after administration), second-phase pain is alleviated by constituents other than EAs, although Pse may partially contribute to the relief of second-phase pain.

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“…Catalpol is a major iridoid glycoside from Shudihuang; it can reduce the production of inflammatory mediators, including IL-6, IL-8, and monocyte chemotactic protein 1 (MCP-1), playing a role similar to the effect of troglitazone via PPAR-γ activation in intestinal cells [ 14 ]. Ephedra polysaccharide from Mahuang decreases the production of cytokines in LPS-induced THP-1 pro-monocytic cells in vitro , and all parameters of inflammation on adjuvant-induced arthritis in Wistar rats in vivo by inhibiting the Toll-like receptor 4 (TLR4) signaling pathway [ 15 ]. Guizhi and Fangfeng have potential as anti-inflammatories and analgesics.…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of Modified Yanghe Decoction in Ankylosing Spondylitis: A Randomized Controlled Trial

Wang

Xiao

2018

Med Sci Monit

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BackgroundThis study evaluated the effects of Modified Yanghe Decoction on pain, disease activity, and functional capacity, and its safety in subjects with ankylosing spondylitis (AS).Material/MethodsA randomized, controlled study of subjects with AS was conducted over 8 weeks to compare the efficacy of the Modified Yanghe Decoction to celecoxib-sulfasalazine therapy. Subjects were evaluated at visit 1, and at weeks 4 and 8 of the trial. The Bath ankylosing spondylitis disease activity index (BASDAI), nocturnal back pain (NBP), total back pain (TBP), patient global disease activity (PGDA), the Bath ankylosing spondylitis functional index (BASFI), and the Bath ankylosing spondylitis metrology index (BASMI) were measured at each time point. Safety was monitored throughout the study through blood, urine, and stool samples, along with heart, liver, and kidney function tests. The ASAS 20 improvement criteria were used as efficacy criteria.ResultsA total of 80 subjects were included. Both treatment groups were effective: 32 subjects (80%) in the Modified Yanghe Decoction group and 34 (85%) in celecoxib-sulfasalazine group met ASAS 20 improvement criteria; no statistically significant difference between groups was observed (P>0.05). Two subjects in the Modified Yanghe Decoction group reported mild diarrhea during the trial. In the celecoxib-sulfasalazine group, 8 subjects experienced upper-abdominal pain; in 3 subjects this was combined with lowered white blood cell count and in 1 subject it was combined with mild proteinuria. This represents a statistically significant difference in safety (P<0.05) between the 2 treatments.ConclusionsThis study demonstrates the efficacy and safety of the Modified Yanghe Decoction in AS treatment, especially for patients who have poor clinical responses, severe adverse reactions, or for patients unable to afford the standard clinical options.

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A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression

Cited by 46 publications

References 27 publications

Characterization of the complete chloroplast genome of Ephedra sinica Stapf (Ephedraceae), a traditional Chinese medicine

Characterization of the complete chloroplast genome of Ephedra sinica Stapf (Ephedraceae), a traditional Chinese medicine

Analgesic Effects of Ephedra Herb Extract, Ephedrine Alkaloids–Free Ephedra Herb Extract, Ephedrine, and Pseudoephedrine on Formalin-Induced Pain

Clinical Efficacy of Modified Yanghe Decoction in Ankylosing Spondylitis: A Randomized Controlled Trial

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