A Pseudo Outbreak of Pantoea dispersa in Total Joint Replacement Procedures

Neonatal septicemia is the most important cause of neonatal mortality. A wide variety of bacteria both aerobic and anaerobic can cause neonatal sepsis. Genus Pantoea is a member of Enterobacteriaceae family that inhabits plants, soil and water and rarely causes human infections, however, Pantoea dispersa has not been reported as a causative organism for neonatal sepsis. We hereby report two neonates with early onset sepsis caused by Pantoea dispersa. Early detection and appropriate antibiotic therapy can improve overall outcome of this rare infection in neonates.

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“…Contaminated sterilized saline used to process Gram stain was responsible for this pseudo-outbreak of P. dispersa . 10 …”

Section: Discussionmentioning

confidence: 99%

Pantoea dispersa: an unusual cause of neonatal sepsis

Mehar

Yadav

Sanghvi

et al. 2013

The Brazilian Journal of Infectious Diseases

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“…The first reported case of Pantoea dispersa was found in an elderly lady with acute myeloid leukemia and multiple myeloma on palliative chemotherapy who was treated for pneumonia and discharged well after a course of antibiotics [12]. Other cases reported were mostly hospital-acquired, from a pseudo-outbreak of Pantoea dispersa joint infection due to a laboratory contaminant [13] to neonatal sepsis found in patients delivered in the same operating theater [14]. On the other hand, invasive fungal infection is commonly found in immunocompromised people [10].…”

Section: Discussionmentioning

confidence: 99%

Disseminated Lodderomyces elongisporus and Pantoea dispersa: A Rare Dual Infection in an Immunocompromised Patient

San,

Mohamed Sukur,

Abdul Hameed

et al. 2024

Cureus

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With the advancement of modern medicine and the prolonged survival of critically ill patients, unusual organisms are increasingly emerging. Initially found in the environment, these rare organisms started presenting as human pathogens, causing significant morbidity and mortality. Here, we present a rare case of disseminated Lodderomyces elongisporus fungemia and Pantoea dispersa bacteremia in a patient with parapneumonic effusion and ruptured liver abscess. This yeast was identified using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF). Although this organism has no antifungal breakpoint, the isolate shows low minimum inhibitory concentration (MIC) to a wide range of antifungals. The importance of effective communication between microbiologists and clinicians and early referral to the infectious disease team was also highlighted in this case for prompt treatment.

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“…[ 3 ] In 2006, a case was reported that two adult patients developed joint infection, and the joint fluid culture revealed growth of P dispersa . [ 7 ] In 2013, a case was reported that P dispersa was identified from 2 Indian neonates with early onset sepsis. [ 8 ] In 2014, a case from Japan was reported that a central line-associated bloodstream infection was caused by P dispersa .…”

Section: Discussionmentioning

confidence: 99%

“…The culture of bronchoalveolar lavage of this patient grew P dispersa [3] . In 2006, a case was reported that two adult patients developed joint infection, and the joint fluid culture revealed growth of P dispersa [7] . In 2013, a case was reported that P dispersa was identified from 2 Indian neonates with early onset sepsis [8] .…”

Section: Discussionmentioning

confidence: 99%

Characteristics and accurate identification of Pantoea dispersa with a case of spontaneous rupture of hepatocellular carcinoma in China

Yang

Zhou

et al. 2022

Medicine

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Introduction: Pantoea dispersa belongs to the genus Pantoea , which is isolated from Enterobacteriaceae . It has been reported to cause some kinds of infections, but there are few detailed studies on it, especially its characteristics and identification methods, which has caused a lot of trouble in clinical work. Patient concerns: A 51-year-old Chinese man was admitted to our hospital with a 7-hour history of progressive abdominal pain. He was previously diagnosed with liver cirrhosis secondary to chronic hepatitis B infection and hepatocellular carcinoma. An emergency hepatic artery embolization for hemostasis was performed under local anesthesia. Forty-eight hours later, the patient presented sudden onset of high fever up to 39.0 °C and chill. Diagnosis: Morphological and phenotypic profiles were performed for preliminary identification for P dispersa . The biochemical features were obtained by VITEK 2 Test Kit. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis and 16S ribosomal RNA sequencing were performed to accurately identify P dispersa . Intervention: Antibiotic therapy of intravenous ceftazidime was started empirically. The antibiotic treatment was switched to intravenous cefepime at the same time because of suspected ceftazidime treatment failure and microbiological sensitivity. Outcomes: The patient remained afebrile, and the second blood culture results were negative. Chest X-ray was normal as well. In order to control the progression of the hepatic lesion, transarterial chemoembolization was performed under local anesthesia. After completion of 14 days of antibiotic treatment, the patient was discharged with no signs of recurrence. Conclusion: P dispersa , a gram-negative bacterium rod, were facultative anaerobic, which displayed yellow pigmentation, round, raised, smooth on culture plates. Conventional analysis was difficult to complete its identification. With biochemical tests, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis and 16S ribosomal RNA sequencing, P dispersa can be accurately identified. It will help physicians understand the related clinical manifestations and make timely and effective treatment for patients.

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A Pseudo Outbreak of Pantoea dispersa in Total Joint Replacement Procedures

Cited by 5 publications

References 0 publications

Pantoea dispersa: an unusual cause of neonatal sepsis

Pantoea dispersa: an unusual cause of neonatal sepsis

Disseminated Lodderomyces elongisporus and Pantoea dispersa: A Rare Dual Infection in an Immunocompromised Patient

Characteristics and accurate identification of Pantoea dispersa with a case of spontaneous rupture of hepatocellular carcinoma in China

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