A protective role of resveratrol against the effects of immobilization stress in corpora lutea of mice in early pregnancy

Ullah, Saif; Mustafa, Sheeraz; Ennab, Wael; Jan, Muhammad; Shafiq, Muhammad; Kavita, Ngekure M.X.; Lü, Zeng-peng; Mao, Dagan; Wei, Quanwei

doi:10.1016/s2095-3119(19)62856-x

Cited by 4 publications

(4 citation statements)

References 48 publications

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“…These excised portions were preserved in a 4% paraformaldehyde solution for subsequent morphological studies. The duodenal, jejunal, and ileal mucosa were carefully scraped with a microscopic glass slide and stored at −80°C for analysis of gene expression and oxidative status ( 33 ).…”

Section: Methodsmentioning

confidence: 99%

Zinc intake ameliorates intestinal morphology and oxidative stress of broiler chickens under heat stress

Hu,

Li,

Peng

et al. 2024

Front. Immunol.

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Zinc (Zn), an essential trace element for poultry, plays a crucial role in promoting growth, improving feed conversion efficiency, enhancing antioxidant activity, and preventing disease. This study investigated the impact of different levels and sources of dietary Zn supplementation on the growth performance, intestinal morphology and antioxidant activity of broiler chickens under heat stress conditions. In this experiment, 1024 Xueshan chickens were divided into eight groups and subjected to heat stress conditions with different levels of Zn supplementation (30 mg/kg, 60 mg/kg, and 90 mg/kg) using organic or inorganic sources. Our findings indicated that dietary Zn supplementation significantly increased the feed-to-weight ratio of broilers during the experimental period under heat stress. Moreover, Zn supplementation positively increased the villus height and villus width in the jejunum and ileum at 74 and 88 days old, with the 60 and 90 mg/kg groups outperforming other groups, and organic Zn was more effective than inorganic Zn. Furthermore, Zn supplementation significantly increased serum antioxidant levels, with higher superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-px) activities, and organic Zn was more effective than inorganic Zn. This study concludes that Zn supplementation is beneficial in mitigating the detrimental impacts of heat stress on broilers. The findings suggest that employing Zn as a strategy can enhance productivity in the poultry industry by positively influencing intestinal morphology and bolstering antioxidant activity to counteract potential stress.

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Section: Methodsmentioning

confidence: 99%

Zinc intake ameliorates intestinal morphology and oxidative stress of broiler chickens under heat stress

Hu,

Li,

Peng

et al. 2024

Front. Immunol.

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“…The sections were then deparaffinized using xylene and gradually rehydrated with ethanol. HE staining was conducted following our laboratory’s protocol [ 56 , 57 , 58 ]. The images of the duodenum, jejunum and ileum were acquired using an Olympus simon-01 microscope (Olympus Optical Co., Ltd., Beijing, China).…”

Section: Methodsmentioning

confidence: 99%

The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters

Ennab

et al. 2023

Animals

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The objective of this study was to investigate the impact of Lycopene and L-Carnitine, individually or in combination, on various physiological and molecular factors related to intestinal health and absorption ability in Roosters, such as intestinal morphology, serum biochemical parameters, genes involved in Lycopene uptake, nutritional transport genes, and tight junction genes. The findings of the study revealed that the combination of L-Carnitine and Lycopene supplementation had been found to increase the serum concentration levels of TP and ALB. Interestingly, the relative mRNA expression of genes responsible for Lycopene uptakes, such as SR-BI and BCO2, was higher in the LC group compared to other groups. Additionally, the expression of specific nutritional transport genes in the duodenum was significantly affected by both CAR and LC supplementation groups. The tight junction gene OCLN showed a significant increase in expression in the combination group compared to using either Lycopene or L-Carnitine alone. This study concludes that using Lycopene and L-carnitine in combination in poultry feed can potentially improve intestinal morphology and serum biochemical parameters, increase Lycopene bioavailability, improve nutrients uptake, and enhance the integrity of duodenal tight junctions in Roosters.

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“…The pharmacological effects of natural metabolites have drawn an enormous amount more attention in recent years ( Pan et al, 2019 ). Clinical data and in vitro studies have shown the beneficial effects of natural products on a wide range of diseases ( Ennab et al, 2019 ; Mustafa et al, 2019 ; Ullah et al, 2020 ; Ennab et al, 2023 ). These changes in the gut microbiota caused by natural substances demonstrate that natural products have a preventive effect on the development of inflammation into cancer.…”

Section: Effect Of Natural Products On Gut-x Axis (Pharmacology Toxic...mentioning

confidence: 99%

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

Li,

Wang,

et al. 2024

Front. Pharmacol.

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Introduction: The gastrointestinal tract is integral to defending against external contaminants, featuring a complex array of immunological, physical, chemical, and microbial barriers. Mycotoxins, which are toxic metabolites from fungi, are pervasive in both animal feed and human food, presenting substantial health risks.Methods: This review examines the pharmacological, toxicological, and microbiological impacts of natural products on mycotoxicosis, with a particular focus on the gut-x axis. The analysis synthesizes current understanding and explores the role of natural products rich in polysaccharides, polyphenols, flavonoids, and saponins. Results: The review highlights that mycotoxins can disrupt intestinal integrity, alter inflammatory responses, damage the mucus layer, and disturb the bacterial balance. The toxins' effects are extensive, potentially harming the immune system, liver, kidneys, and skin, and are associated with serious conditions such as cancer, hormonal changes, genetic mutations, bleeding, birth defects, and neurological issues. Natural products have shown potential anticancer, anti-tumor, antioxidant, immunomodulatory, and antitoxic properties.Discussion: The review underscores the emerging therapeutic strategy of targeting gut microbial modulation. It identifies knowledge gaps and suggests future research directions to deepen our understanding of natural products' role in gut-x axis health and to mitigate the global health impact of mycotoxin-induced diseases.

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A protective role of resveratrol against the effects of immobilization stress in corpora lutea of mice in early pregnancy

Cited by 4 publications

References 48 publications

Zinc intake ameliorates intestinal morphology and oxidative stress of broiler chickens under heat stress

Zinc intake ameliorates intestinal morphology and oxidative stress of broiler chickens under heat stress

The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters

Natural products for Gut-X axis: pharmacology, toxicology and microbiology in mycotoxin-caused diseases

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