volume 191, issue 3, P1393-1403 2013
DOI: 10.4049/jimmunol.1300052
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Yi Zhang, Xuchen Zhang, Peiying Shan, Clayton R. Hunt, Tej K. Pandita, Patty J. Lee

Abstract: Administering high levels of inspired oxygen, or hyperoxia, is commonly used as a life-sustaining measure in critically ill patients. However, prolonged exposures can exacerbate respiratory failure. Our previous study showed that toll-like receptor 4 (TLR4) confers protection against hyperoxia-induced lung injury and mortality. Hsp70 has potent cytoprotective properties and has been described as a TLR4 ligand in cell lines. We sought to elucidate the relationship between TLR4 and Hsp70 in hyperoxia-induced lu…

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