A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis

Matsuzaki, Takashi; Saito, Mineki; Usuku, Koichiro; Nose, Hirohisa; Izumo, Shuji; Arimura, Kimiyoshi; Osame, Mitsuhiro

doi:10.1016/j.jns.2005.05.011

Cited by 55 publications

(36 citation statements)

References 37 publications

(38 reference statements)

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“…Moreover, the intake of fermented milk containing L. casei strain Shirota restored NK cell activity in subjects with relatively low NK cell activity (20,24,25). Those results suggest that orally ingested L. casei strain Shirota may enhance innate immunity and suppress the occurrence of cancer.…”

mentioning

confidence: 70%

“…Increasing evidence has also supported the possibility that L. casei strain Shirota can act as an effective immunomodulator in humans. Oral administration of L. casei strain Shirota restored NK cell activity in subjects with relatively low NK cell activity (20,24,25), although it remains to be investigated whether L. casei strain Shirota-mediated recovery of NK cell activity was connected with a reduction in cancer incidence (2,12,27). Previous studies using experimental murine models showed that L. casei strain Shirota could prevent infections of pathogenic bacteria and viruses through the activation of innate immune defenses (10,22) and inhibit the development of allergies, autoimmune diseases, and inflammatory bowel diseases, probably through normalizing dysregulated host immune systems (16,19,21,23,34).…”

Section: Discussionmentioning

confidence: 97%

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Essential Roles of Monocytes in Stimulating Human Peripheral Blood Mononuclear Cells with Lactobacillus casei To Produce Cytokines and Augment Natural Killer Cell Activity

Shida

Suzuki

Kiyoshima-Shibata

et al. 2006

Clin Vaccine Immunol

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mentioning

confidence: 70%

Section: Discussionmentioning

confidence: 97%

Essential Roles of Monocytes in Stimulating Human Peripheral Blood Mononuclear Cells with Lactobacillus casei To Produce Cytokines and Augment Natural Killer Cell Activity

Shida

Suzuki

Kiyoshima-Shibata

et al. 2006

Clin Vaccine Immunol

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“…When the subjects were divided into two subgroups based on the severity of nasal symptom score before the start of ingestion, nasal SMS of the participants with moderate-to-severe nasal symptom scores was lower in the LcS group than in the placebo group at 4 weeks and 5 weeks, indicating that LcS may delay the onset of allergic symptoms in patients with a moderate-to-severe condition. In previous studies, we found that a daily drink of 80 ml of fermented milk containing LcS caused recovery of natural killer cell activity in humans [17,18,19]. Therefore, we considered that 80 ml of fermented milk containing LcS could be sufficient for modulating human immune function.…”

Section: Discussionmentioning

confidence: 99%

Effects of Probiotics on Allergic Rhinitis Induced by Japanese Cedar Pollen: Randomized Double-Blind, Placebo-Controlled Clinical Trial

Tamura

Shikina

Morihana

et al. 2006

Int Arch Allergy Immunol

103

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Background:Lactobacillus casei strain Shirota (LcS) has been found to exert antiallergic effects in animal experiments, but there is little information about its clinical effects in human patients with allergy. Methods: We performed a randomized double-blind, placebo-controlled study to investigate the effects of LcS in patients with allergic rhinitis triggered by Japanese cedar pollen (JCP). Participants were asked to drink fermented milk containing LcS (LcS group) or placebo (control group) for 8 weeks. Clinical symptoms and immunological parameters were compared between the two groups. Results: Symptom-medication scores (SMS) worsened in accordance with the increase in the amount of scattered JCP. In terms of the nasal and ocular SMS, there was no significant difference between the LcS group and the placebo group during the ingestion period. In the subgroup of patients with moderate-to-severe nasal symptom scores before starting the ingestion of test samples, supplementation with LcS tended to reduce nasal SMS. Conclusion: These results indicate that fermented milk containing LcS does not prevent allergic symptoms in patients sensitive to JCP, but may delay the occurrence of allergic symptoms in patients with moderate-to-severe nasal symptom scores.

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“…Moreover, the symptoms of spinal spasticity that are peculiar to patients with HTLV-I-associated myelopathy (HAM) are relieved through the long-term consumption of LcS-fermented milk [22] . The long-term consumption of LcS-fermented milk was found to significantly increase the NK cell activity in HAM patients, in whom natural immuno-competence is decreased.…”

Section: Nagata Et Almentioning

confidence: 99%

The Effectiveness of <b><i>Lactobacillus</i></b> Beverages in Controlling Infections among the Residents of an Aged Care Facility: A Randomized Placebo-Controlled Double-Blind Trial

Nagata

Asahara²,

Wang³

et al. 2015

Ann Nutr Metab

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Backgrounds/Aims: To clarify the usefulness of Lactobacillus casei strain Shirota (LcS)-fermented milk in the normalization of bowel movements and improvement of infection control for the elderly residents and staff of facilities for the elderly. Methods: A randomized placebo-controlled double-blind test was performed among the elderly residents (average age, 85) and staff members (average age, 37) of facilities for the elderly. The participants randomly received either LcS-fermented milk or a placebo beverage once daily for 6 months. Clinical data and enteric conditions were compared between the 2 groups. Results: A significantly lower incidence of fever and improved bowel movements were seen in the LcS-fermented milk group (n = 36) in comparison to the placebo group (n = 36). The numbers of Bifidobacterium and Lactobacillus were significantly higher (p < 0.01), the numbers of destructive bacteria such as Clostridium difficile were significantly lower (p < 0.05), and the fecal acetic acid concentration and total acidity were significantly higher in the LcS group. A significant difference in the intestinal microbiota, fecal acetic acid, and pH was also observed between the LcS and placebo groups among the facility's staff members. Conclusions: The long-term consumption of LcS-fermented milk may be useful for decreasing the daily risk of infection and improving the quality of life among the residents and staff of facilities for the elderly.

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A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis

Cited by 55 publications

References 37 publications

Essential Roles of Monocytes in Stimulating Human Peripheral Blood Mononuclear Cells with Lactobacillus casei To Produce Cytokines and Augment Natural Killer Cell Activity

Essential Roles of Monocytes in Stimulating Human Peripheral Blood Mononuclear Cells with Lactobacillus casei To Produce Cytokines and Augment Natural Killer Cell Activity

Effects of Probiotics on Allergic Rhinitis Induced by Japanese Cedar Pollen: Randomized Double-Blind, Placebo-Controlled Clinical Trial

The Effectiveness of <b><i>Lactobacillus</i></b> Beverages in Controlling Infections among the Residents of an Aged Care Facility: A Randomized Placebo-Controlled Double-Blind Trial

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