A prospective study of vitamin intake and the risk of hearing loss in men

Shargorodsky, Josef; Curhan, Sharon G.; Eavey, Roland D.; Curhan, Gary C.

doi:10.1016/j.otohns.2009.10.049

Cited by 69 publications

(77 citation statements)

References 18 publications

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“…Moreover, prospective associations between the outcome measure in this study and several risk factors have recently been demonstrated 13,29 . The participants in this cohort are not representative of the adult population in the U.S., but the follow-up rates are high and the information provided is reliable.…”

Section: Discussionmentioning

confidence: 63%

A Prospective Study of Cardiovascular Risk Factors and Incident Hearing Loss in Men

et al. 2010

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Objective-Hearing loss is the most common sensory disorder in the US, afflicting over 36 million people. Cardiovascular risk factors have been associated with hearing loss risk in crosssectional studies, but prospective data are currently lacking.Methods-We prospectively evaluated the association between diagnosis of hypertension, diabetes mellitus, hypercholesterolemia, smoking and body mass index (BMI) and incidence of hearing loss. Participants were 26,917 men in the Health Professionals Follow-up Study, aged 40-74 years at baseline in 1986. Study participants completed questionnaires about lifestyle and medical history every two years.Information on self-reported professionally diagnosed hearing loss and year of diagnosis was obtained from the 2004 questionnaire, and cases were defined as hearing loss diagnosed between 1986 and 2004. Multivariable-adjusted hazard ratios (HRs) were calculated using Cox proportional hazards regression models.Results-3,488 cases of hearing loss were identified. History of hypertension (HR 0.96, 95% CI 0.88-1.03), diabetes mellitus (HR 0.92, 95% CI 0.78-1.08), or obesity (HR 1.02, 95% CI 0.90-1.15 for BMI≥30 compared to normal range of 19-24.9) was not significantly associated with hearing loss risk, while hypercholesterolemia (HR 1.10, 95% CI 1.02-1.18) and past smoking history (HR 1.09, 95% CI 1.01-1.17) were associated with a significantly increased risk of hearing loss after multivariate adjustment.Conclusion-A history of hypertension, diabetes mellitus, or obesity is not associated with increased risk of hearing loss, while a history of past smoking or hypercholesterolemia has a small but statistically significant association with increased risk of hearing loss in adult males.

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Section: Discussionmentioning

confidence: 63%

A Prospective Study of Cardiovascular Risk Factors and Incident Hearing Loss in Men

et al. 2010

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“…The Panel considers that the available evidence does not establish that modulation of any of these markers is in itself a health outcome, which could be considered as a suitable criterion for deriving a DRV for α-tocopherol. Other studies also investigated the relationship between 'vitamin E'/α-tocopherol and diabetes mellitus (cohort studies (Arnlov et al, 2009;Song et al, 2011)), osteoporosis (one case-control study (Zhang et al, 2006)) and hearing loss (one cohort study (Shargorodsky et al, 2010)). One study (Song et al, 2011) investigated the relationship between the frequency of use (i.e.…”

Section: 'Vitamin E'/α-tocopherol Intake and Health Consequencesmentioning

confidence: 99%

Scientific Opinion on Dietary Reference Values for vitamin E as α‐tocopherol

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2015

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Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for vitamin E. In this Opinion, the Panel considers vitamin E as α-tocopherol only. The Panel considers that Average Requirements (ARs) and Population Reference Intakes (PRIs) for vitamin E (as α-tocopherol) cannot be derived for adults, infants and children, and therefore defines Adequate Intakes (AIs), based on observed intakes in healthy populations with no apparent α-tocopherol deficiency in the EU. This approach considers the range of average intakes of α-tocopherol and of α-tocopherol equivalents estimated by EFSA from dietary surveys in children and adults in nine countries. The Panel notes the uncertainties in the available food composition and consumption data, the fact that most EU food composition databases contain values for vitamin E as α-tocopherol equivalents, as well as the contribution of average α-tocopherol intakes to average α-tocopherol equivalent intakes in these countries. For adults, an AI for α-tocopherol is set at 13 mg/day for men and 11 mg/day for women. For children aged 1 to < 3 years, an AI for α-tocopherol is set at 6 mg/day for both sexes. For children aged 3 to < 10 years, an AI for α-tocopherol is set at 9 mg/day for both sexes. For children aged 10 to < 18 years, an AI for α-tocopherol is set at 13 mg/day for boys and 11 mg/day for girls. For infants aged 7-11 months, an AI for α-tocopherol of 5 mg/day is derived by extrapolating upwards from the estimated α-tocopherol intake in exclusively breast-fed infants aged 0-6 months and rounding. For pregnant or lactating women, the Panel considers that there is no evidence for an increased dietary α-tocopherol requirement, and the same AI is set as for non-pregnant non-lactating women. Vitamin E is a fat-soluble vitamin. Previously, the term vitamin E was used as the generic term for four tocopherols (α, β, γ, δ) and four tocotrienols (α, β, γ, δ), which are organic compounds that possess antioxidant activity to a different degree. Factors have been used to convert food contents of tocopherols and tocotrienols to α-tocopherol equivalents. In this Opinion, based on the available evidence and in line with other authoritative bodies, the Panel considers vitamin E as being α-tocopherol only. Its naturally occurring form is RRR-α-tocopherol. Commercially available forms of α-tocopherol include RRR-α-tocopherol, a synthetic form that contains in equal proportions the eight stereoisomers of α-tocopherol (RRR-, RRS-, RSR-, RSS-and their enantiomers SSS-, SSR-, SRS-, SRR-) and is called all-rac-α-tocopherol, and their esterified forms. © EuropeanEfficient α-tocopherol absorption requires the presence of fat. The Panel considered that the average α-tocopherol absorption from a usual diet is about 75 %. This is based on the means observed in two balance studies and in a kinetic study using a multi-compartmental model of α-tocopherol metabolism. After its intestinal absorption, α-toc...

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“…The ACEMg treatment was administered to guinea pigs (Le Prell et al 2007 ) and CBA/J mice (Le Prell et al 2011 ) showing reduced permanent threshold shifts after NIHL and also reduced threshold shift after gentamicin ototoxicity (Le Prell et al 2014 ). Studies in humans indicate that regular dietary intake of antioxidants correlates with lower risks of hearing loss (Durga et al 2007 ;Shargorodsky et al 2010 ;Choi et al 2014 ). Chapter 6 by Spankovich discusses epidemiological data on the role of nutrients in hearing loss prevention in humans.…”

Section: Mitochondria Oxidative Stress and Age-related Hearing Lossmentioning

confidence: 99%