BackgroundThere are no studies that have evaluated the correlation between self‐rated pain, peri‐implant clinical and radiographic parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and crestal bone loss [CBL]) and whole salivary interleukin (IL)‐1β, IL‐6, and tumor necrosis factor‐alpha (TNF‐α) levels among patients with and without peri‐implantitis.PurposeThe objective was to evaluate the correlation between self‐evaluated pain, peri‐implant clinical and radiographic parameters and whole salivary IL‐1β, IL‐6, and TNF‐α levels among patients with and without peri‐implantitis.Materials and MethodsIncluded in this study were patients with and without peri‐implantitis. Data regarding age, gender, duration of implants in function, and self‐perceived pain were recorded using a question. Self‐rated pain was assessed using the numeric pain rating scale. Peri‐implant PD, PI, BOP, and CBL were recorded and samples of unstimulated whole saliva samples were obtained. Whole salivary IL‐1β, IL‐6, and TNF‐α were measured. Sample‐size was approximated and group comparisons were completed. P‐values <.05 were regarded as statistically significant.ResultsForty‐six male individuals (21 with and 25 without peri‐implantitis) were included. The mean age of individuals with and without PiD was 53.71 ± 5.45 and 50.92 ± 6.26 years, respectively. The mean self‐rated pain score in patients with and without PiD was 3 ± 2 and zero, respectively. There was no significant difference in the SFR among patients with and without peri‐implantitis. Levels of IL‐1β (P < .01), IL‐6 (P < .01), and TNF‐α (P < .01) were significantly elevated in subjects with than without peri‐implantitis. Regression analysis‐based results reflected no significant association between increasing self‐rated pain and whole salivary IL‐1β, IL‐6, and TNF‐α levels.ConclusionProinflammatory cytokines (IL‐1β, IL‐6, and TNF‐α) are more often expressed in the UWS of patients with than without peri‐implantitis. However, the correlation between self‐rated pain and whole salivary proinflammatory cytokine profile in patients with peri‐implantitis remains unclear.