A prospective study of serial maternal serum zinc levels and pregnancy outcome

McMichael, Anthony J.; Dreosti, Ivor E.; Gibson, G. T.; Hartshorne, J. M.; Buckley, R.A.; Colley, D. P.

doi:10.1016/0378-3782(82)90008-1

Cited by 55 publications

(20 citation statements)

References 14 publications

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“…Although many functions for MT have been proposed, several lines of evidence support the idea that one function of MT during early life may be that of a zinc-storage protein (30, 3 1). Supportive of this idea is the finding of similar negative correlations between maternal plasma zinc at term and birth wt in human populations (32)(33)(34).…”

Section: Discussionmentioning

confidence: 88%

Influence of Marginal Maternal Zinc Deficiency on Pregnancy Outcome and Infant Zinc Status in Rhesus Monkeys

Lönnerdal

et al. 1989

Pediatr Res

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ABSTRACT. To investigate the effects of marginal zinc deficiency on early development, rhesus monkeys were fed a diet marginally deficient in zinc (M, 4 pglg) throughout pregnancy and during the first month of lactation. Despite the low concentration of zinc in the diet, M dams did not develop overt signs of zinc deficiency. However, compared to control dams fed diets adequate in zinc (C; 100 pg Zn/ g), M dams showed a low response to the mitogens concanavalin A and phytohemagglutinin. Pregnancy outcome was similar in the two groups and all of the neonates were judged to be healthy at delivery. From birth until d 30 of age, the infants were closely monitored for signs of zinc deficiency, and at d 30, they were killed and tissues were removed and analyzed for a number of parameters reported to be affected by zinc status. At birth, M infants had low plasma zinc concentrations compared to controls; however, this difference was not observed at d 30. D 30 M infants showed a normal response to the mitogens concanavalin A and phytohemagglutinin, but showed a low response to pokeweed mitogen. Tissue (liver, brain, spleen, kidney, and heart) trace element concentrations were similar in the two groups of infants, as were liver metallothionein concentrations and @Zn uptakelretention by isolated hepatocytes. Infant wt gain was inversely correlated with plasma zinc, liver zinc, and liver metallothionein concentrations in both the M and C groups. These results demonstrate that feeding a diet containing 4 fig zinclg to rhesus monkeys during pregnancy and lactation does not result in marked signs of zinc deficiency, although subtle signs occur in both the mother and infant. The data also support the concept that infant growth is associated with a depletion of tissue zinc stores. (Pediatr Res 26:470-477, 1989)

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Section: Discussionmentioning

confidence: 88%

Influence of Marginal Maternal Zinc Deficiency on Pregnancy Outcome and Infant Zinc Status in Rhesus Monkeys

Lönnerdal

et al. 1989

Pediatr Res

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“…For example, plasma Zn correlated weakly with birth weight when sampled at mid pregnancy (McMichael et al 1982), more strongly in early rather than in later pregnancy, i.e. third trimester (Neggers et al 1990), or not at all Buzina et al 1980;Hambidge et al 1983;Campbell-Brown et al 1985;Hunt et al 1985;Tuttle et af.…”

Section: N F a N C Y A N D C H I L D H O O Dmentioning

confidence: 99%

Zinc Nutrition in Developing Countries

1994

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Table 1. Zinc?, phytic acidf and [phytate] : [zinc] molar ratios of some foods and composite dishes consumed in Ghana and Malawi Food, and scientific name or recipe Zn Cereals Maize flour, 95 ' YO extraction (Zea mays L.) Maize flour, 65 % extraction Maize bran Maize dough Sorghum flour (Sorghum bicofor (L.) Moench) Rice (Oryza sariva) Ground nuts, boiled (Arachis hypogaea L.) Ground nuts, flour Pigeon peas, fresh (Cajanus cajan (L.) Millsp.) Pigeon peas, dry Kidney beans, fresh (Phaseolus vulgaris L.) Cowpeas, boiled (Vigna unguiculata (L.) Walp.) Lima beans, fresh (Phaseolus lunatus L.) Bengal beans, fresh (Stizolobium aterrimum Piper & Tracey) Pumpkin leaf (Cucurbita maxima Duch. ex Lam.) Chinese cabbage (Brussica chinensis L.) Okra leaf (Hibiscus esculentus (L.)) Okra (Hibiscus esculentus (L.)) Cassava leaf (Manihot esculenta Crantz) Cocoyam leaves (Xanthosoma sp. Schott.) Amaranth leaves (Amaranth sp. L.) Roots and plantain (boiled) Sweet potato (Ipomoea batatas L.) Yam (Dioscorea sp. L.) Cocoyam (Xanthosoma sp.) Cassava (Manihot sp.) Cassava dough, fermented Gari: dry fermented cassava, not boiled Plantain, ripe (Musa parudisiaca L.) Plantain, unripe (Musa purudisiaca L.) Water yam (Dioscorea alatu L.) Avocado pear (Persea americana Mill.) Banana (Musa paradisiaca L.) Mango, raw (Mangifera indica L.) Chitumbuwa (mixture of water, maize flour and pounded bananas formed into a round cake and fried in oil) African bread (mixture of water, maize flour and bananas formed into a cake, wrapped in banana leaves and boiled until cooked) African cake (mixture of water, maize flour and sugar baked in tin can)

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“…When nutrient intake during the last trimester of pregnancy was assessed by dietary recall in mothers shortly after birth, low Zn intake was found to be significantly associated with intrauterine growth retardation (Simmer et al 1987~). Maternal plasma Zn levels have been shown to be negatively correlated with birth weight in vegetarian women (Abu-Assal & Craig, 1984) and also women in Australia (McMichael et al 1982), but the validity of assessing Zn status by means of plasma Zn levels in pregnancy is questionable. Ward et al (1987) analysed placentas from 100 women who had obstetrically normal births and found that placental Zn concentrations were positively correlated with birth weight and head circumference over the lower end of the 'normal' range.…”

Section: S U S a N J F A I R W E A T H E R -T A I Tmentioning

confidence: 99%

Zinc in Human Nutrition

Fairweather‐Tait

1988

Nutr. Res. Rev.

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A prospective study of serial maternal serum zinc levels and pregnancy outcome

Cited by 55 publications

References 14 publications

Influence of Marginal Maternal Zinc Deficiency on Pregnancy Outcome and Infant Zinc Status in Rhesus Monkeys

Influence of Marginal Maternal Zinc Deficiency on Pregnancy Outcome and Infant Zinc Status in Rhesus Monkeys

Zinc Nutrition in Developing Countries

Zinc in Human Nutrition

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