A Prospective Study of Pigmentation, Sun Exposure, and Risk of Cutaneous Malignant Melanoma in Women

Veierød, Marit B.; Weiderpass, Elisabete; Thörn, Magnus; Hansson, Johan; Lund, Eiliv; Armstrong, Bruce K.; Adami, Hans‐Olov

doi:10.1093/jnci/djg075

Cited by 302 publications

(292 citation statements)

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“…Kraemer et al, reported carcinoma of the tip of the tongue upto 6 % of cases while Goyal et al reported in 2 out of the 10 cases reported [12,13]. Incidence of internal malignancies like intracranial, bone marrow, stomach, testis, lungs and pancreas upto 10-20 fold higher than the normal population are reported [17,19]. Initially the skin shows slight diffuse erythema which is associated with scaling and small areas of hyperpigmentation resembling freckles seen as early as 1-2 year old, later skin atrophies with mottled pigmentation and telangiectasias mimicking chronic radio-dermatitis.…”

Section: Discussionmentioning

confidence: 99%

“…Malignancies appear in adolescence proving fatal in the third decade [8,9]. Cutaneous cancers i.e., BCC and SCC are the commonest cancers universally, occurs in old age while in teenage XP patients [19,20]. BCC is currently the most common cutaneous cancer in humans [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous cancers i.e., BCC and SCC are the commonest cancers universally, occurs in old age while in teenage XP patients [19,20]. BCC is currently the most common cutaneous cancer in humans [19,20]. Incidence ratio of BCC to SCC is 1.5 worldwide while males are affected 1.8 times more than females [21,22].…”

Section: Discussionmentioning

confidence: 99%

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Xeroderma Pigmentosum: Clinicopathological Review of the Multiple Oculocutaneous Malignancies and Complications

Halkud

Shenoy

Naik

et al. 2014

Indian J Surg Oncol

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Multiple oculo-cutaneous malignancies are a common manifestation on sun-exposed facial areas in patients with Xeroderma pigmentosum (XP). Commonly seen are the basal cell carcinoma and the squamous cell carcinomas which manifest in the early first decade in contrast to fifth and sixth decade in the general population. XP manifests as photosensitivity, hyperpigmentation, premature skin aging and malignant changes like squamous cell carcinoma, basal cell carcinoma, fibrosarcoma and rarely malignant melanoma as well as internal malignancies. We report 11 cases of Xeroderma pigmentosa managed in our institute which included sex males and five females. All had photosensitivity, hyperpigmentation and consanguinity with facial malignant lesions like SCC and BCC. Ocular signs of photophobia and excessive lacrimation was seen in all the cases while blurring of vision due to corneal clouding, corneal injection, pterygium and limbal SCC were seen in 5 cases. SCC of the lids were seen in 7 cases while BCC seen in 8 cases and limbal and conjunctival SCC seen in one case. All were managed with excision while one case of melanoma with neck secondaries needed radical neck dissection while the other orbital exenteration. Oculo-cutaneous malignancies occur in the sun exposed areas so patients are advised regular follow up with speciality care. Awareness about the rare condition and importance of early detection and prevention of UV rays induced skin damage should be propagated. The disease is ultimately fatal, life can be prolonged by simple preventive measures to minimize sun exposure and early detection of the skin lesions and management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Xeroderma Pigmentosum: Clinicopathological Review of the Multiple Oculocutaneous Malignancies and Complications

Halkud

Shenoy

Naik

et al. 2014

Indian J Surg Oncol

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“…5,7,18 The lack of association between BMI or weight and melanoma risk in our pooled analyses is consistent with the findings of 5 5,10,12,15,16 of 8 other case-control studies, [5][6][7]10,12,13,15,16 and 7 17-23 of 8 cohort studies. [17][18][19][20][21][22][23][24] To our knowledge there are no previous studies that have examined the association between weight gain and risk of melanoma among women. Our pooled analyses excluded men because the original study aims of the analysis focused on sex steroid-related factors in women.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Interpretation of the results has been hampered by differences in methodology and inconsistent approaches to defining overweight and obesity. Moreover, only a few studies have examined associations according to histologic subtype 14,15,25 or menopausal status, 7,8 which may be important given the possible link between reproductive and hormonal factors and risk of melanoma in women.…”

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confidence: 99%

Anthropometric factors and risk of melanoma in women: A pooled analysis

Olsen

Green

Zens

et al. 2007

Intl Journal of Cancer

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Anthropometric factors such as height, weight and body mass index are related to the occurrence of certain malignancies in women including cancers of the breast, ovary and endometrium. Several studies have investigated the relation between height and weight or body mass and the risk of cutaneous melanoma in women, but results have been inconsistent. We conducted a collaborative analysis of these factors using the original data from 8 case-control studies of melanoma in women (2,083 cases and 2,782 controls), with assessment of the potential confounding effects of socioeconomic, pigmentary and sun exposure-related factors. Women in the highest quartile of height had an increased risk of melanoma [pooled odds ratio (pOR) 1.3, 95% confidence interval (CI) 1.1-1.6]. We also found an elevated risk associated with weight gain in adult life of 2 kg or more (pOR 1.5, 95% CI 1.1-2.0). Stratifying by age at melanoma diagnosis (<50, ‡50 yr), we found this risk greater among women <50 yr of age. Associations were unaffected by adjustment for other known risk factors for melanoma. There was no evidence that the effects varied for different histologic subtypes of cutaneous melanoma. There was no association with body weight per se, body mass index, or body surface area, either recent or in young adulthood. In aggregate, data from these studies suggest that greater height and weight gain may be risk factors for cutaneous melanoma in women. ' 2007 Wiley-Liss, Inc.Key words: melanoma; anthropometry; weight; height; body mass index Anthropometric factors such as height, weight and body mass index are related to the occurrence of certain malignancies in women including cancers of the breast, ovary and endometrium. 1,2 Increasing height has been associated with increased risk of cancers of the breast and colon. 2,3 Obesity consistently has been associated with an increased risk of hormone-related cancers such as colon, breast (in postmenopausal women) and endometrium, and also kidney. 4 Evidence for an effect on risk of melanoma, however, remains inconclusive.Several studies have investigated the association between height and weight or body mass and the risk of melanoma in women. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Interpretation of the results has been hampered by differences in methodology and inconsistent approaches to defining overweight and obesity. Moreover, only a few studies have examined associations according to histologic subtype 14,15,25 or menopausal status, 7,8 which may be important given the possible link between reproductive and hormonal factors and risk of melanoma in women. 6,14,[26][27][28][29][30][31] The prevalence of overweight and obesity is growing dramatically in most parts of the world, and generally is higher in women than in men. 32 This is predicted to have major consequences on the incidence of obesity-related diseases. Quantitative assessment of the association between obesity and melanoma is thus important, and may provide further insight into disease etiolo...

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Association of UV Index, Latitude, and Melanoma Incidence in Nonwhite Populations—US Surveillance, Epidemiology, and End Results (SEER) Program, 1992 to 2001

Eide¹,

2005

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A Prospective Study of Pigmentation, Sun Exposure, and Risk of Cutaneous Malignant Melanoma in Women

Cited by 302 publications

References 30 publications

Xeroderma Pigmentosum: Clinicopathological Review of the Multiple Oculocutaneous Malignancies and Complications

Xeroderma Pigmentosum: Clinicopathological Review of the Multiple Oculocutaneous Malignancies and Complications

Anthropometric factors and risk of melanoma in women: A pooled analysis

Association of UV Index, Latitude, and Melanoma Incidence in Nonwhite Populations—US Surveillance, Epidemiology, and End Results (SEER) Program, 1992 to 2001

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