A prospective randomized trial comparing hypofractionation with conventional fractionation radiotherapy for T1–2 glottic squamous cell carcinomas: Results of a Korean Radiation Oncology Group (KROG-0201) study

Single Vocal Cord Irradiation: Image Guided Intensity Modulated Hypofractionated Radiation Therapy for T1a Glottic Cancer: Early Clinical Results

“…The prospective randomized trial of the Korean Radiation Oncology group (KROG-0201 study), comparing hypofractionated (63 Gy/28 fractions) with conventional radiation schedules (66 Gy/33 fractions), showed no significant differences in LC-rates and toxicity between both arms. The 5-year LC-rates for patients with T1a disease trend positively in the hypofractionated, compared to the conventional arm (93% vs. 76.7%, p=0.056) (15).…”

“…Although many radiation oncologists are concerned that using large fraction sizes may lead to an increase in late toxicity, different studies have shown that hypofractionated schemes of radiotherapy for early stage glottic cancer have resulted in comparable LC rates and toxicity profiles, compared to conventional schemes (14,15). The prospective randomized trial of the Korean Radiation Oncology group (KROG-0201 study), comparing hypofractionated (63 Gy/28 fractions) with conventional radiation schedules (66 Gy/33 fractions), showed no significant differences in LC-rates and toxicity between both arms.…”

Hypofractionated accelerated radiotherapy in T1–3 N0 cancer of the larynx: A prospective cohort study with historical controls

“…12,18,[22][23][24][25] In some reports these indicators reach 100%. 2,13,26 The publications on hypofractionated accelerated RT for larynx cancer present results in T1-T2 tumors while in our study T3 tumors were diagnosed in 8% of patients in the H group.…”

“…33 Two papers report results of randomized trials. 13,23 Due to differences in methodology, endpoints and follow-up duration the comparison of results is of a limited value. No difference in toxicity between standard and hypofractionated protocols was found in published reports of hypofractionated RT of the laryngeal cancer.…”

“…No difference in toxicity between standard and hypofractionated protocols was found in published reports of hypofractionated RT of the laryngeal cancer. 11,13,18,22,23,25 In majority of these reports a fraction dose of 2.25-2.5 Gy was used. The dose >3.0 Gy was linked to a higher complications rate, 13,34 but in a group of 200 patients reported by Gowda et al in which 3.12-3.28 Gy doses were used for 3 weeks up to a total of 50-52.5 Gy, early and late toxicity were low.…”