A Prospective Randomized Study Evaluating the Role of Oral Curcumin along with Chemoradiationin Management of Locally Advanced Head and Neck Carcinoma

Kumar, Deepak; Kaur, Paramjeet; Bansal, Navneeta; Kumar, J; Khurana, Anil; Chauhan, Akshansha

doi:10.9734/ijtdh/2016/25780

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Regarding the anti-inflammatory and antioxidant effects of curcumin, the effectiveness of topical curcumin in alleviating the OM induced by chemotherapy and radiotherapy has been shown in some studies [25][26][27][28][29]. Furthermore, 1 g curcumin capsules have proved to be effective in alleviating the OM induced by head and neck radiotherapy [30] 80 mg SinaCurcumin in the form of nanomicelle also was evaluated and it was curative for OM induced by head and neck radiotherapy [31]. Because of anti-inflammatory and anti-oxidative characteristics of Curcumin, we expected that it would be an appropriate treatment for oral mucositis induced by chemotherapy and head and neck radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial

Kia

Basirat

Saedi

et al. 2021

BMC Complement Med Ther

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Background One of the most prevalent complications of chemotherapy and radiotherapy is oral mucositis (OM) and manifests as erythema and ulceration. Curcumin is one of the components of turmeric and possesses anti-inflammatory and anti-oxidative features. Some of studies have proved the effectiveness of Curcumin in OM. This study aimed to investigate the effects of nanomicelle Curcumin on OM related chemotherapy and head and neck radiotherapy. Methods In this clinical trial study, 50 patients underwent chemotherapy with or without head and neck radiotherapy were divided into study and control group. The study group was received Curcumin nanomicelle capsules 80 mg twice a day and the control group took placebo two times a day for 7 weeks and the severity and pain of OM was measured. Results Oral mucositis severity in control group in the first (P = 0.010), fourth (P = 0.022) and seventh (P < 0.001) weeks were significantly more than the study group. Pain grade in study group was lower than control group only in the seventh week. (P = 0.001) Additionally, NRS incremental gradient in control group was more than study group. OM severity in patients who underwent only chemotherapy in the control group were significantly more than the study group in all weeks. In patients who were under chemotherapy and head and neck radiotherapy, OM in control group was significantly more intense than the study group only in the fourth and seventh weeks. Conclusions Nabomicelle Curcumin capsules is effective on prevention and treatment of head and neck radiotherapy and especially chemotherapy induced OM. Trial registration Registered 12 February 2019 at Iranian Registry of Clinical Trials (IRCT). IRCT code: IRCT20100101002950N6. https://en.irct.ir/trial/36665. GUMS ethical code: IR.Gums.Rec.1397.296.

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Section: Introductionmentioning

confidence: 99%

Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial

Kia

Basirat

Saedi

et al. 2021

BMC Complement Med Ther

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Curcumin as a complementary treatment in oncological therapy: a systematic review

Gutsche,

Dörfler,

Hübner

2024

Eur J Clin Pharmacol

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Purpose Curcumin, the active ingredient in turmeric, is employed by numerous cancer patients to support conventional cancer therapy. This systematic review aims to summarize the existing clinical evidence and to provide an overview of the potential benefits and risks associated with curcumin supplementation. Methods In January 2024, we conducted a systematic search of five electronic databases (Embase, Cochrane, PsycInfo, CINAHL, and Medline) using a complex search strategy. We included randomized controlled trials on the use, effectiveness, and potential harm of additional curcumin therapy in adult patients under cancer treatment. The risk of bias was assessed using Cochrane revised Risk of Bias Tool 2.0. Results This systematic review included 34 randomized controlled trials involving 2580 patients out of 11143 search results. Included patients were primarily diagnosed with head and neck cancer, followed by breast, prostate, and colorectal cancer. Therapy concepts encompassed topical or systemic curcumin administration. The studies reported heterogeneous results concerning oral and skin symptoms, pain, weight alteration and changes in body composition, survival, and disease progression. Significant findings were reported for oral mucositis and weight loss. Considering risk of bias, all studies had moderate to high risk of bias. Regarding side effects, one study reported significantly more vomiting in the curcumin group. Conclusion Although the results suggest promise in reducing mucositis and weight loss, a clear statement regarding the effectiveness of curcumin therapy on cancer patients cannot be made due to heterogeneous results and methodological limitations of the involved studies. Further investigations of higher quality are necessary to derive a definite recommendation for action.

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Potentiality of Curcumin Against Radio-Chemotherapy Induced Oral Mucositis: A Review

Sarangi

2024

Indian J Surg Oncol

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A Prospective Randomized Study Evaluating the Role of Oral Curcumin along with Chemoradiationin Management of Locally Advanced Head and Neck Carcinoma

Cited by 3 publications

References 7 publications

Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial

Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial

Curcumin as a complementary treatment in oncological therapy: a systematic review

Potentiality of Curcumin Against Radio-Chemotherapy Induced Oral Mucositis: A Review

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