Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial

Abstract

Background One of the most prevalent complications of chemotherapy and radiotherapy is oral mucositis (OM) and manifests as erythema and ulceration. Curcumin is one of the components of turmeric and possesses anti-inflammatory and anti-oxidative features. Some of studies have proved the effectiveness of Curcumin in OM. This study aimed to investigate the effects of nanomicelle Curcumin on OM related chemotherapy and head and neck radiotherapy. Methods In this clinical trial study, 50 patients underwent chemotherapy with or without head and neck radiotherapy were divided into study and control group. The study group was received Curcumin nanomicelle capsules 80 mg twice a day and the control group took placebo two times a day for 7 weeks and the severity and pain of OM was measured. Results Oral mucositis severity in control group in the first (P = 0.010), fourth (P = 0.022) and seventh (P < 0.001) weeks were significantly more than the study group. Pain grade in study group was lower than control group only in the seventh week. (P = 0.001) Additionally, NRS incremental gradient in control group was more than study group. OM severity in patients who underwent only chemotherapy in the control group were significantly more than the study group in all weeks. In patients who were under chemotherapy and head and neck radiotherapy, OM in control group was significantly more intense than the study group only in the fourth and seventh weeks. Conclusions Nabomicelle Curcumin capsules is effective on prevention and treatment of head and neck radiotherapy and especially chemotherapy induced OM. Trial registration Registered 12 February 2019 at Iranian Registry of Clinical Trials (IRCT). IRCT code: IRCT20100101002950N6. https://en.irct.ir/trial/36665. GUMS ethical code: IR.Gums.Rec.1397.296.

Effectiveness of Curcumin in Reducing Self-Rated Pain-Levels in the Orofacial Region: A Systematic Review of Randomized-Controlled Trials

“…Five hundred and five studies that did not fulfill the eligibility criteria were excluded. In total, nineteen studies [ 24 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] were included and processed for data extraction ( Figure 1 ).…”

“…Nineteen RCTs were included [ 24 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. The number of participants ranged between 11 and 178 individuals.…”

“…The number of participants ranged between 11 and 178 individuals. Fifteen studies [ 24 , 35 , 39 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 49 , 50 , 51 , 52 , 54 ] reported the gender of the participants in which the number of males and females ranged from 15 to 44 and 9 to 46 individuals, respectively. In all studies [ 24 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ], individuals in the test group used turmeric products for the management of pain in the OFR.…”

“…Data extraction from the nineteen eligible RCTs [ 24 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] was performed by two authors (BS, ER), and pertinent information was summarized according to the (a) reference, (b) number of subjects, (c) subject gender, (d) study groups, (e) subjects’ mean age and range, (f) source of OFP, (g) pain rating scale, (h) follow-up period, (i) study characteristics related to curcumin use, (j) type of control, (k) risk of bias, and (l) main study outcomes (reduction in self-rated pain levels) and conclusions.…”

Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers

“…All patients received 80 mg of curcumin nanomicelle capsules twice a day for 7 weeks. The results showed that in patients who were under chemotherapy and head and neck radiotherapy, curcumin administration managed to significantly decrease the OM severity [ 72 ]. Similar results were presented by Charantinath et al who evaluated the efficacy and safety of a curcumin gel in the alleviation of OM in cancer patients undergoing radiochemotherapy [ 73 ].…”