A Prospective Randomized Study Comparing Patients with Morbid Obesity Submitted to Sleeve Gastrectomy With or Without Omentectomy

Sdralis, El.; Αργέντου, Μαρία-Ιωάννα; Mead, Nancy; Kehagias, Ioannis; Alexandridis, T; Kalfarentzos, Fotis

doi:10.1007/s11695-013-0925-z

Cited by 41 publications

(27 citation statements)

References 30 publications

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“…Besides the time and the own reduction of weight, the type of surgical technology can also influence. Sdralis et al [29] have reported that after 1 year postoperatively, omentin-1 levels increased significantly in the sleeve gastrectomy group and decreased in the omentectomy group.…”

Section: Discussionmentioning

confidence: 98%

Impact of 2 Different Hypocaloric Diets on Serum Omentin Levels in Obese Subjects

Luis¹,

Izaola²,

Primo³

et al. 2018

Ann Nutr Metab

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Background and Aims: Omentin-1 might play a role in insulin resistance and obesity. This study is aimed at evaluating the influence of weight loss treatment on omentin-1 concentrations and other parameters after 2 different hypocaloric diets in obese subjects. Methods: A total of 239 obese subjects were randomly allocated during 12 weeks (Diet I – high-fat diet vs. Diet II – low fat diet), and their anthropometric and biochemical status were evaluated. Results: After dietary intervention, BMI, weight, fat mass, waist circumference, systolic blood, triglycerides, LDL cholesterol, insulin levels and homeostasis model assessment for insulin resistance decreased in a statistical manner from their base values. After consuming diet II (low fat diet), the omentin-1 levels increased in males (20 ± 14 ng/mL) and females (35 ± 19 ng/mL). No changes were observed in omentin-1 levels after consuming hypocaloric diet type I (high fat). The multiple regression analyses after weight loss with diet I adjusted by age and sex showed a statistical association between BMI kg/m² (Beta –0.33: 95% CI –4.58 to –0.11) and post-treatment omentin-1 levels. The analysis after weight loss with diet II showed a statistical association with BMI kg/m² (Beta –0.31: 95% CI –3.93 to –0.08) and insulin UI/L (Beta –0.25: 95% CI –4.63 to –0.05) with post-treatment omentin-1 levels. Conclusions: Our design showed a significant increase in serum omentin-1 levels after weight loss secondary to a low fat hypocaloric diet, in contrast to no changes following consuming a high fat hypocaloric diet.

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Section: Discussionmentioning

confidence: 98%

Impact of 2 Different Hypocaloric Diets on Serum Omentin Levels in Obese Subjects

Luis¹,

Izaola²,

Primo³

et al. 2018

Ann Nutr Metab

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“…Sdralis et al [24] evaluated the impact of omentectomy in patients with morbid obesity undergoing sleeve gastrectomy (SG) on adipokine secretion. After 1 year postoperatively, omentin-1 levels increased significantly in the control group only with SG after a mean weight loss of 50 kg and decreased in the omentectomy group.…”

Section: Discussionmentioning

confidence: 99%

Omentin-1 Changes following Biliopancreatic Diversion and Relationship with Cardiovascular Risk Factors

et al. 2018

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Introduction: Omentin-1 might play a role in the pathogenesis of insulin resistance and obesity. The aim of the present study was to evaluate the influence of weight loss after biliopancreatic diversion on serum omentin-1 concentrations. Material and Methods A Caucasian population of 24 morbid obese patients was analyzed before and after 12 months of a biliopancreatic diversion surgery. Biochemical and anthropometric evaluation were realized at basal visit and at 12 months. Body weight, fat mass, waist circumferences, blood pressure, fasting blood glucose, fasting insulin, insulin resistance (HOMA-IR), lipid concentrations and omentin-1 were measured. Results: After bariatric surgery and in both gender groups (males vs. females); BMI, weight, fat mass, waist circumference, blood pressure, glucose , total cholesterol, LDL cholesterol, triglycerides, HOMA-IR and fasting insulin decreased in a statistical manner from basal values. Omentin-1 levels increased after bariatric surgery and in both gender the improvement was similar (males vs. females); (delta: –87.1 ± 19.0 ng/dL; p = 0.02 vs. –93.8 ± 28.1 ng/dL; p = 0.03). In the multiple regression analysis adjusted by age and sex; BMI kg/m² (Beta –0.32: 95% CI –3.98 to –0.12) and insulin UI/L (Beta –0.41: 95% CI –8.38 to –0.16) remained in the model with basal omentin-1 levels as dependent variable. The regression model with post-surgery omentin-1 levels as dependent variable showed as independent variables BMI kg/m² (Beta –0.13: 95% CI –7.69 to –0.09) and insulin UI/L (Beta –0.24: 95% CI –5.69 to –0.08), too. Conclusion: This study showed a significant increase in omentin-1 levels after weight loss secondary biliopancreatic diversion surgery. A weak negative correlation with BMI and basal insulin levels was detected.

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“…These findings are in accordance with interventional studies that involve removal of the omental depot in obese individuals. In eight out of nine published studies, addition of omentectomy to gastric bypass or sleeve gastrectomy did not augment weight loss or the improvement in insulin sensitivity and other metabolic indices achieved by the bariatric intervention itself (Table 2) [84-91]. Although longer-term follow-up and the incidence of cardiovascular events can be assessed in future studies, these data question the causative role of omental adipose tissue in metabolic dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Multiple Adipose Depots Increase Cardiovascular Risk via Local and Systemic Effects

Karastergiou

Fried

2013

Curr Atheroscler Rep

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Adipose tissue modifies the development of cardiovascular disease in a complex manner: obesity is a major risk factor, but particularly when accompanied with a central fat distribution. For that reason the characteristics of visceral adipose tissue attracted the majority of research interest thus far and measurement of waist circumference is now recommended for everyday clinical practice. However, the direct, causative role of visceral fat in cardiometabolic disease remains to be established. Epidemiological and clinical studies show that accumulation of fat subcutaneously, in the gluteo-femoral area, is protective for cardiovascular disease, but the exact molecular mechanisms remain again unclear. In the last few years, imaging allowed the study of smaller fat depots that may interact locally with important tissues: epicardial fat with the myocardium, perivascular fat with the vessel wall and the developing atherosclerotic plaque, renal sinus fat with the renal artery. Unraveling the heterogeneous fat distribution and metabolic phenotypes in human obesity will facilitate optimal assessment of cardiovascular risk in overweight and obese individuals.

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A Prospective Randomized Study Comparing Patients with Morbid Obesity Submitted to Sleeve Gastrectomy With or Without Omentectomy

Abstract: The theoretical advantages of omentectomy in regard to weight loss and obesity-related abnormalities are not confirmed in this prospective study. Furthermore, omentectomy does not induce important changes in the inflammatory status in patients undergoing SG.

Cited by 41 publications

References 30 publications

Impact of 2 Different Hypocaloric Diets on Serum Omentin Levels in Obese Subjects

Impact of 2 Different Hypocaloric Diets on Serum Omentin Levels in Obese Subjects

Omentin-1 Changes following Biliopancreatic Diversion and Relationship with Cardiovascular Risk Factors

Multiple Adipose Depots Increase Cardiovascular Risk via Local and Systemic Effects

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